Mesenchymal stromal cells (MSC) anti-microbial effect in acute respiratory distress syndrome (ARDS) is mediated in part by enhanced alveolar macrophage phagocytosis through cell contact-dependent mitochondrial transfer leading to improved macrophage bioenergetics

2016 ◽  
Author(s):  
Megan Jackson ◽  
Thomas Morrison ◽  
Danny McAuley ◽  
Cecilia O'Kane ◽  
Michael Matthay ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Alveolar Macrophage ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Distress Syndrome ◽  
Cell Contact ◽  
Macrophage Phagocytosis ◽  
Mitochondrial Transfer

scholarly journals In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

2015 ◽  
Vol 4 (10) ◽  
pp. 1199-1213 ◽  
Author(s):  
Oscar E. Simonson ◽  
Dimitrios Mougiakakos ◽  
Nina Heldring ◽  
Giulio Bassi ◽  
Henrik J. Johansson ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Distress Syndrome ◽  
In Vivo Effects

scholarly journals Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Sara Rolandsson Enes ◽  
Anna D. Krasnodembskaya ◽  
Karen English ◽  
Claudia C. Dos Santos ◽  
Daniel J. Weiss
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Lung Diseases ◽  
Distress Syndrome ◽  
Research Progress ◽  
Cell Therapies ◽  
Therapeutic Benefits

Recent advances in cell based therapies for lung diseases and critical illnesses offer significant promise. Despite encouraging preclinical results, the translation of efficacy to the clinical settings have not been successful. One of the possible reasons for this is the lack of understanding of the complex interaction between mesenchymal stromal cells (MSCs) and the host environment. Other challenges for MSC cell therapies include cell sources, dosing, disease target, donor variability, and cell product manufacturing. Here we provide an overview on advances and current issues with a focus on MSC-based cell therapies for inflammatory acute respiratory distress syndrome varieties and other inflammatory lung diseases.

scholarly journals In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

2015 ◽  
Vol 5 (6) ◽  
pp. 845-845 ◽  
Author(s):  
Oscar E. Simonson ◽  
Dimitrios Mougiakakos ◽  
Nina Heldring ◽  
Giulio Bassi ◽  
Henrik J. Johansson ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Distress Syndrome ◽  
In Vivo Effects
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