Respiratory- and voice symptoms among extremely preterm born children with prolonged ventilator dependency

Background: Determining optimal nutritional regimens in extremely preterm infants remains challenging. This study aimed to evaluate the effect of a new nutritional regimen and individual macronutrient intake on white matter integrity and neurodevelopmental outcome. Methods: Two retrospective cohorts of extremely preterm infants (gestational age <28 weeks) were included. Cohort B (n = 79) received a new nutritional regimen, with more rapidly increased, higher protein intake compared to cohort A (n = 99). Individual protein, lipid, and caloric intakes were calculated for the first 28 postnatal days. Diffusion tensor imaging was performed at term-equivalent age, and cognitive and motor development were evaluated at 2 years corrected age (CA) (Bayley-III-NL) and 5.9 years chronological age (WPPSI-III-NL, MABC-2-NL). Results: Compared to cohort A, infants in cohort B had significantly higher protein intake (3.4 g/kg/day vs. 2.7 g/kg/day) and higher fractional anisotropy (FA) in several white matter tracts but lower motor scores at 2 years CA (mean (SD) 103 (12) vs. 109 (12)). Higher protein intake was associated with higher FA and lower motor scores at 2 years CA (B = −6.7, p = 0.001). However, motor scores at 2 years CA were still within the normal range and differences were not sustained at 5.9 years. There were no significant associations with lipid or caloric intake. Conclusion: In extremely preterm born infants, postnatal protein intake seems important for white matter development but does not necessarily improve long-term cognitive and motor development.

Download Full-text

National population-based cohort study found that visual-motor integration was commonly affected in extremely preterm born children at six-and-a-half years

Acta Paediatrica ◽

10.1111/apa.14231 ◽

2018 ◽

Vol 107 (5) ◽

pp. 831-837 ◽

Cited By ~ 5

Author(s):

Jenny Bolk ◽

Ylva Fredriksson Kaul ◽

Lena Hellström-Westas ◽

Karin Stjernqvist ◽

Nelly Padilla ◽

...

Keyword(s):

Cohort Study ◽

Population Based ◽

National Population ◽

Visual Motor Integration ◽

Extremely Preterm ◽

Visual Motor ◽

Preterm Born

Download Full-text

Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years

Acta Paediatrica ◽

10.1111/apa.14925 ◽

2019 ◽

Vol 109 (1) ◽

pp. 85-92 ◽

Cited By ~ 1

Author(s):

Mehreen Zaigham ◽

Karin Källén ◽

Karel Maršál ◽

Per Olofsson

Keyword(s):

Neurodevelopmental Outcome ◽

Risk Of Death ◽

Increased Risk ◽

Extremely Preterm ◽

Preterm Born

Download Full-text

Extremely preterm born infants and long‐term neurodevelopmental outcomes

Acta Paediatrica ◽

10.1111/apa.15126 ◽

2019 ◽

Vol 109 (7) ◽

pp. 1499-1499

Author(s):

Despina D. Briana ◽

Ariadne Malamitsi‐Puchner

Keyword(s):

Neurodevelopmental Outcomes ◽

Extremely Preterm ◽

Preterm Born

Download Full-text

Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age

Brain and Cognition ◽

10.1016/j.bandc.2019.103615 ◽

2019 ◽

Vol 136 ◽

pp. 103615 ◽

Cited By ~ 1

Author(s):

Maksym Tokariev ◽

Virve Vuontela ◽

Piia Lönnberg ◽

Aulikki Lano ◽

Jaana Perkola ◽

...

Keyword(s):

Working Memory ◽

White Matter ◽

School Age ◽

Brain Responses ◽

White Matter Microstructure ◽

Extremely Preterm ◽

Preterm Born

Download Full-text

Erratum to: Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Child Psychiatry & Human Development ◽

10.1007/s10578-016-0647-2 ◽

2016 ◽

Vol 47 (6) ◽

pp. 1009-1009

Author(s):

Liedewij Verhaeghe ◽

Mieke Dereu ◽

Petra Warreyn ◽

Isabel De Groote ◽

Piet Vanhaesebrouck ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

High Risk ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Extremely Preterm ◽

Preterm Born ◽

Very High

Download Full-text

THE DIAGNOSTIC SIGNIFICANCE OF FLUORESCENCE ANGIOGRAPHY FOR THE EARLY DETECTION AND PROGNOSTICATION OF THE DEVELOPMENT OF ACTIVE RETINOPATHY OF PREMATURITY IN THE INFANTS BORN ON THE DEADLINES OF GESTATION

Russian Pediatric Ophthalmology ◽

10.18821/1993-1859-2017-12-1-17-22 ◽

2017 ◽

Vol 12 (1) ◽

pp. 17-22 ◽

Cited By ~ 2

Author(s):

E. I Saidasheva ◽

V. A Lyubimenko ◽

S. V Buyanovskaya ◽

F. V Kovshov

Keyword(s):

Early Detection ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Diagnostic Value ◽

Retinal Blood Flow ◽

Fluorescence Angiography ◽

Diagnostic Significance ◽

Extremely Preterm ◽

Group 2 ◽

Preterm Born

Aim. The objective of the present study was to elucidate the fluorescent angiographic characteristics, such as the features of retinal and choroidal microcirculation, depending on the duration of the active course of retinopathy of prematurity in the infants born on the deadlines of gestation (the gestational age of 21-26 weeks). Materials and methods. The study included 65 patients presenting with retinopathy of prematurity. A total of 102 sessions of fluorescence angiography (FA) of the retina were carried out, with 40% of the sessions being performed in duplicate. The gestational age of the infants ranged from 22 to 26 (mean 24.9+-1.0) weeks, their body weight at birth varied from 490 to 1,400 (mean BW 774.8+-152.6) g. All the patients were subdivided into 4 groups. Group 1 was comprised of 8 (12.3%) children at the initial stages of retinopathy of prematurity, group 2 consisted of 28 (43.1%) children presenting with threshold retinopathy of prematurity, group 3 was composed of 20 (30.8%) children with the recurring disorder, and group 4 involved 9 (13.8%) children experiencing induced regression of this pathology. The photographs of the fundus and digital video FA images were obtained with the use of the RetCam3 pediatric retinal camera (“Clarity”, USA). The 10% fluorescein solution was administered intravenously in the form of bolus injections at a dose of 7.5 mg/kg. Results. The present study has revealed some characteristic fluorescent and angiographic features of active retinopathy of prematurity in the extremely preterm born infants including instability of the retinal blood flow, variability in the filling of the choroid, various types of pathological branching of the blood vessels at the boundary between vascularized and avascular retina, etc. The comparative analysis of the angiograms and colour images of the fundus obtained with the use of the RetCam3 camera gave evidence of the high diagnostic value of the fluorescence angiography technique that provides the possibility for the early objective visualization and registration of the pathological changes in the retinal vasculature characteristic of the initial and threshold stages of the disease as well as for the reliable detection of the signs of its relapse (the local sites of re-proliferation) and regression of the pathology being considered. Conclusion. The application of the fluorescence angiography technique for the examination of the markedly prematurely born infants provides a safe and efficient tool allowing to greatly optimize both the early detection and prognostication of the development of active retinopathy of prematurity in the infants born on the deadlines of gestation.

Download Full-text

Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/archdischild-2019-318531 ◽

2020 ◽

Vol 106 (1) ◽

pp. 45-50 ◽

Cited By ~ 1

Author(s):

Sanne Arjaans ◽

Meindina G Haarman ◽

Marcus T R Roofthooft ◽

Marian W F Fries ◽

Elisabeth M W Kooi ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Bronchopulmonary Dysplasia ◽

Medical Center ◽

Survival Rates ◽

Patient Characteristics ◽

University Hospital ◽

Resolution Rate ◽

Extremely Preterm ◽

Postmenstrual Age ◽

Preterm Born

ObjectiveTo determine the survival and evolution of pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD) in extremely premature born infants beyond 36 weeks postmenstrual age (PMA).DesignA single-centre retrospective cohort study from a university hospital.PatientsExtremely preterm (gestational age <30 weeks and/or birth weight <1000 g) infants, born between 2012 and 2017, in the University Medical Center Groningen with confirmed PH at/beyond 36 weeks PMA.Main outcome measuresSurvival, mortality rate and PH resolution. Patient characteristics, treatment, presence and evolution of PH were collected from patient charts.ResultsTwenty-eight infants were included. All had BPD, while 23 (82%) had severe BPD and 11 infants (39%) died. Survival rates at 1, 3 and 7 months from 36 weeks PMA were 89%, 70% and 58%, respectively. In 16 of the 17 surviving infants, PH resolved over time, with a resolution rate at 1 and 2 years corrected age of 47% and 79%, respectively. At 2.5 years corrected age, the resolution rate was 94%.ConclusionsThese extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.

Download Full-text