The association between lung function in adults and the socioeconomic profile in a long-term follow-up

Abstract Background: Thousands of the Coronavirus Disease 2019 (COVID-19) patients have been discharged from hospitals, long-term follow-up studies are required to evaluate the prevalence of post-COVID-19 fibrosis.Methods: This study involves 462 laboratory confirmed patients with COVID-19 who were admitted to Shenzhen Third People’s Hospital from January 11, 2020 to April 26, 2020. A total of 457 patients underwent thin-section chest CT scans during the hospitalization or after discharge to identify the pulmonary lesion. A total of 289 patients were followed up from 90 days to 150 days after the onset of the disease.Results: Parenchymal bands, irregular interfaces, meshwork and traction bronchiectasis were the most common CT features in all COVID-19 patients. 86.87%, 74.40%, 79.56%, 68.12% and 62.03% patients developed with pulmonary fibrosis and 4.53%, 19.61%, 18.02%, 38.30% and 48.98% patients reversed pulmonary fibrosis during the 0-30, 31-60, 61-90, 91-120 and >120 days after onset, respectively. It was observed that Age, BMI, Fever, and Highest PCT were predictive factors for sustaining fibrosis even after 90 days from onset. A predictive model of the persistence with pulmonary fibrosis was developed based-on the Logistic Regression method with an accuracy, PPV, NPV, Sensitivity and Specificity of the model of 76%, 71%, 79%, 67%, and 82%, respectively. Only a fraction of COVID-19 patients suffered with abnormal lung function after 90 days from onset, and the ratio of abnormal lung function did not differ on a statistically significant level between the fibrotic and non-fibrotic groups.Conclusions: Long-term pulmonary fibrosis was more likely to develop in patients with older age, high BMI, severe/critical condition, fever, long time to turn the viral RNA negative, pre-existing disease and delay to admission. Fibrosis developed in COVID-19 patients could be reversed in about a half of the patients after 120 days from onset. The pulmonary function of most of COVID-19 patients with pulmonary fibrosis could turn to normal condition after three months from onset. An effective prediction model with an average Area Under the Curve (AUC) of 0.84 was established to predict the persistence of pulmonary fibrosis in COVID-19 patients for early diagnosis.

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A long–term follow–up of lung function in survivors of paraquat poisoning

Human & Experimental Toxicology ◽

10.1191/096032700678815729 ◽

2000 ◽

Vol 19 (2) ◽

pp. 99-103 ◽

Cited By ~ 40

Author(s):

M Yamashita ◽

Y Ando

Keyword(s):

Lung Function ◽

Normal Limit ◽

Signs And Symptoms ◽

Gas Transfer ◽

Normal Range ◽

Laboratory Findings ◽

Paraquat Poisoning ◽

Long Term Follow Up

1 Respiratory failure is a frequent cause of death in moderate to severe paraquat poisoning, and a tran- sient fall in the gas transfer factor may be seen in mild poisoning. 2 The objectives of this study were to detect long-term changes in lung function in survivors of paraquat poisoning. 3 We analyzed 12 survivors retrospectively for age, sex, signs and symptoms, laboratory findings, chest X-ray findings, serum paraquat level, and lung function test. The first and the follow-up lung tests were performed at 3.7 + 1.4 weeks and 3.4 + 1.4 years, respectively. 4 Serum paraquat levels were assayed in all patients and 3/12 were above the Proudfoot's predictive line. Liver dysfunction (GOT > 50) and renal dysfunction (BUN > 30) were noted in 5/12 and 8/12, respectively. DL/VA was lower than the normal limit in the first study (3.9 + 0.6 L), but increased significantly and returned to the normal range in the follow-up study (4.5 + 0.6 L).%VC was within the normal range in either examina- tion, but significantly decreased in the follow-up.%TLC was within the normal range in the first study (87 + 13%), but significantly decreased below the normal limit in the follow-up (81 + 13%). 5 These results indicate that survivors of paraquat poisoning may be left with a restrictive type of pulmonary dysfunction and suggest that a long-term follow-up of lung function may be necessary for survivors of paraquat poisoning.

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The association between lung function in adults and future burden of obstructive lung diseases in a long-term follow-up

10.1183/13993003.congress-2020.4011 ◽

2020 ◽

Author(s):

Lene Maria Ørts ◽

Bodil Hammer Bech ◽

Torsten Lauritzen ◽

Anders Helles Carlsen ◽

Annelli Sandbæk ◽

...

Keyword(s):

Lung Function ◽

Lung Diseases ◽

Obstructive Lung Diseases ◽

Future Burden ◽

Long Term Follow Up

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Clinical Predictors of Lung Function in Patients Recovering from Mild COVID-19

10.21203/rs.3.rs-1124510/v1 ◽

2021 ◽

Author(s):

Arturo Cortes-Telles ◽

Esperanza Figueroa-Hurtado ◽

Diana Lizbeth Ortiz-Farias ◽

Gerald Stanley Zavorsky

Keyword(s):

Lung Function ◽

Forced Expiratory Volume ◽

Clinical Predictors ◽

Runny Nose ◽

Post Evaluation ◽

Long Term Follow Up ◽

Night Sweats ◽

Definition Of

Abstract Background: There are few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentile) in Hispanics recovering from mild COVID-19. We also examined the prevalence of a restrictive spirometric pattern as defined by the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) being ≥ LLN with the FVC being < LLN. Finally, we wanted to examine factors that cause the prevalence of an impaired DLCO to vary between studies.Methods: In this observational study, adult patients (n = 146) with mild COVID-19 were recruited from a Long-term follow-up COVID-19 clinic in Yucatan, Mexico between March, and August 2021. Spirometry, DLCO, and self-reported signs/symptoms were recorded 34 ± 4 days after diagnosis. Results: At post-evaluation, 20% and 30% patients recovering from COVID-19 were classified as having a restrictive spirometric pattern and impaired DLCO, respectively; 13% had both. The most prevalent reported symptoms were fatigue (73%), persistent cough (43%), shortness of breath (42%) and a blocked/runny nose (36%). Increased age, a blocked/runny nose, excessive night sweats, and a restrictive spirometric pattern increased probability of having an impaired DLCO. The proportion of patients with previous mild COVID-19 who had impaired DLCO increased by 12% when the definition of impaired DLCO was < 80% predicted instead of < LLN. Having severe (compared to mild) COVID-19 increased the percentage of those with impaired DLCO by 20%. Conclusions: One-third of patients with mild COVID-19 have impaired DLCO thirty-four days post-diagnosis. One-fifth of patients have a restrictive spirometric pattern. The criteria that define impaired DLCO and the severity of COVID-19 disease affects the proportion of those with impaired DLCO at follow-up.

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Decreased Lung Function and Exercise Capacity in Fontan Patients. A Long-term Follow-up

Scandinavian Cardiovascular Journal ◽

10.1080/14017430310007045 ◽

2003 ◽

Vol 37 (1) ◽

pp. 58-63 ◽

Cited By ~ 9

Author(s):

Eva Strömvall Larsson ◽

Bengt O. Eriksson ◽

Rune Sixt

Keyword(s):

Lung Function ◽

Exercise Capacity ◽

Long Term Follow Up ◽

Fontan Patients

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Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800105x ◽

2019 ◽

Vol 42 ◽

Cited By ~ 2

Author(s):

John P. A. Ioannidis

Keyword(s):

Mental Health ◽

Mental Disease ◽

Brain Disorders ◽

Social Stressors ◽

Labor Education ◽

Mental Diseases ◽

Long Term Follow Up ◽

Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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