scholarly journals Clinical Predictors of Lung Function in Patients Recovering from Mild COVID-19

2021 ◽  
Author(s):  
Arturo Cortes-Telles ◽  
Esperanza Figueroa-Hurtado ◽  
Diana Lizbeth Ortiz-Farias ◽  
Gerald Stanley Zavorsky
Keyword(s):  
Lung Function ◽  
Forced Expiratory Volume ◽  
Clinical Predictors ◽  
Runny Nose ◽  
Post Evaluation ◽  
Long Term Follow Up ◽  
Night Sweats ◽  
Definition Of

Abstract Background: There are few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentile) in Hispanics recovering from mild COVID-19. We also examined the prevalence of a restrictive spirometric pattern as defined by the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) being ≥ LLN with the FVC being < LLN. Finally, we wanted to examine factors that cause the prevalence of an impaired DLCO to vary between studies.Methods: In this observational study, adult patients (n = 146) with mild COVID-19 were recruited from a Long-term follow-up COVID-19 clinic in Yucatan, Mexico between March, and August 2021. Spirometry, DLCO, and self-reported signs/symptoms were recorded 34 ± 4 days after diagnosis. Results: At post-evaluation, 20% and 30% patients recovering from COVID-19 were classified as having a restrictive spirometric pattern and impaired DLCO, respectively; 13% had both. The most prevalent reported symptoms were fatigue (73%), persistent cough (43%), shortness of breath (42%) and a blocked/runny nose (36%). Increased age, a blocked/runny nose, excessive night sweats, and a restrictive spirometric pattern increased probability of having an impaired DLCO. The proportion of patients with previous mild COVID-19 who had impaired DLCO increased by 12% when the definition of impaired DLCO was < 80% predicted instead of < LLN. Having severe (compared to mild) COVID-19 increased the percentage of those with impaired DLCO by 20%. Conclusions: One-third of patients with mild COVID-19 have impaired DLCO thirty-four days post-diagnosis. One-fifth of patients have a restrictive spirometric pattern. The criteria that define impaired DLCO and the severity of COVID-19 disease affects the proportion of those with impaired DLCO at follow-up.

scholarly journals Long-term Follow-up in Patients Diagnosed and Treated for Pulmonary Tuberculosis: What Really Happened With the Lung Function?

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 951A
Author(s):  
Pedro Marcos ◽  
Isabel Otero ◽  
Maria Fernández-Marrube ◽  
Maria Rodriguez-Valcarcel ◽  
Luis Mariñas ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Tuberculosis ◽  
Long Term Follow Up

The association between lung function in adults and the socioeconomic profile in a long-term follow-up

2021 ◽  
Author(s):  
Lene Maria Ørts ◽  
Bodil Hammer Bech ◽  
Torsten Lauritzen ◽  
Anders Helles Carlsen ◽  
Annelli Sandbæk ◽  
...  
Keyword(s):  
Lung Function ◽  
Long Term Follow Up ◽  
Socioeconomic Profile

Acetabular Growth Potential in the Dysplastic and Normal Hip. A Long-Term Follow-Up

1994 ◽  
Vol 4 (1) ◽  
pp. 53-58
Author(s):  
F. Specchiulli ◽  
L. Scialpi ◽  
G. Solafino ◽  
L. Battelli ◽  
L. Nitti
Keyword(s):  
Surgical Treatment ◽  
Hip Dislocation ◽  
Normal Subjects ◽  
Growth Potential ◽  
Long Term Follow Up ◽  
Definition Of ◽  
Initial Correction

In CHD (Congenital Hip Dislocation), the elements which determine the degree and quality of acetabular growth are not clear. This has caused a great deal of controversy on the capability of development of the cotyloid cavity, hence on the indications to reconstructive surgical treatment. In order to study the behavior of che cotyloid cavity, two groups of patients were taken into consideration: normal subjects and subjects with CHD. In normal subjects the median value of the Hingelreiner angle was 19°–4'± 1° (normal limit), at 1 year old. The acetabular index decreases rapidly until becoming stable at adult values at the age of 8-10 years of age. The distinctive characteristics of the hip with spontaneous recovery from cotyloid dysplasia could be defined as follows: a) the higher critical value on average is reached after 24 months of treatment; b) once the borderline is reached, the dislocated hip evolves in the same way as the healthy hip; c) the earlier treatment is started, the sooner correction of the H angle is obtained; d) the cotyloid cavity continues to develop even after 5 years from reduction. In CHD with terminal residual dysplasia, an initial correction of the H angle is followed by a sudden interruption in acetabular development, which remains inadequate and will never reach normal values. These data allow not only the definition of the acetabular growth potential, but also the establishment of more precise indications for reconstructive surgical treatment.

scholarly journals Megavoltage pituitary irradiation lowers but seldom leads to safe GH levels in acromegaly: a long-term follow-up study

1998 ◽  
pp. 160-163 ◽  
Author(s):  
NC Thalassinos ◽  
S Tsagarakis ◽  
G Ioannides ◽  
I Tzavara ◽  
C Papavasiliou
Keyword(s):  
Additional Data ◽  
External Beam ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Biochemical Cure ◽  
Definition Of ◽  
Pituitary Irradiation ◽  
Tsh Deficiency

Radiotherapy (RT) has long been used in the treatment of acromegaly, but confusion regarding the definition of biochemical cure has hampered interpretation of previous reports on the outcome of this treatment. In the present study we present additional data using the currently accepted criteria of biochemical cure in a large group of patients followed up by our department. Forty-six acromegalic patients were treated with external beam megavoltage RT and followed up for a mean of 7.6 years (range 2-22 years). Only four patients had had previous surgical treatment by either transsphenoidal or transfrontal routes. Following RT, mean basal GH levels decreased from 30.9 ng/ml (5-96 ng/ml) to 11.5 ng/ml (1-36 ng/ml) at 10 years of follow up with a further fall to 6.1 ng/ml (1-29 ng/ml) in those patients followed up for more than 10 years. As a result, although mean GH levels of less than 5 ng/ml were achieved in 9/28 (30.1%) at 5 years, 6/19 (31.6%) at 10 years, and in 6/11 (54.5%) of those patients followed up for more than 10 years post-RT, only 0/28 (0%), 7/28 (25%), 4/19 (21%) and 1/11 (1%) achieved GH levels of <2.5 ng/ml at 2, 5. 10 and >10 years following RT. Thus, in the whole series only 10/48 (20.8%) patients showed a decrease of GH level to less than 2.5 ng/ml at their latest follow up. Hypopituitarism as a result of RT was only infrequently observed in this series; gonadal deficiency developed in 12 (26.6%) patients, thyrotrophin (TSH) deficiency in 3 (6.6%) and adrenocorticotrophin deficiency in 2 (4.4%). In conclusion, megavoltage RT is an effective treatment for the control of GH hypersecretion in acromegaly, with a continuing lowering effect for several years following RT but seldom leads to safe GH levels.

Decreased Lung Function and Exercise Capacity in Fontan Patients. A Long-Term Follow-Up

2003 ◽  
Vol 37 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Eva Strömvall Larsson ◽  
Bengt O. Eriksson ◽  
Rune Sixt
Keyword(s):  
Lung Function ◽  
Exercise Capacity ◽  
Long Term Follow Up ◽  
Fontan Patients

Long-Term Success of Metal Endobronchial Stents in Lung Transplant Recipients

2021 ◽  
Author(s):  
Shimon Izhakian ◽  
Walter Wasser ◽  
Avraham Unterman ◽  
Oren Fruchter ◽  
Oleg Gorelik ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Transplantation ◽  
Intervention Group ◽  
Forced Expiratory Volume ◽  
Metal Stents ◽  
Control Group ◽  
Stent Insertion ◽  
Severe Bleeding

Abstract Background Bronchial stenosis is a common complication following lung transplantation. We evaluated long-term associations of the use of self-expandable metal stents (SEMSs) with lung function tests, patient safety, and survival. Methods A retrospective chart review of 582 lung transplantations performed at our institution between January 2002 and January 2018. Fifty-four patients with SEMSs (intervention group) were matched one-to-one to patients without SEMSs (control group) using propensity score matching for age, sex, the year, and type of transplantation (unilateral/bilateral), and underlying disease. Data regarding long-term lung function and survival were compared between the groups. Results During a median follow-up of 54.8 months, the difference in survival between the study groups was not statistically significant (p = 0.2). Following 5, 7.5 and 10 years, values of mean forced expiratory volume in 1 second (FEV1) were comparable between patients with and without SEMSs as follows: 59.5 versus 62.6% (p = 0.2), 55.9 versus 55.0% (p = 0.4), and 63.5 versus 61.9% (p = 0.3), respectively. In the intervention group, a significant increase in the mean FEV1 was observed in 60 days after stent insertion (from 41.9 ± 12.8 to 49.5 ± 16.7% days, p < 0.001). Long-term complications following stent insertion included severe bleeding (1.8%), stent fractures (7.4%), stent stenosis (7.4%), stent collapse (3.7%), endobronchial pressure ulcer (1.9%), and stent migration (1.9%). Conclusion SEMS insertion is associated with a positive sustained effect on lung function, without increasing long-term mortality. Thus, airway stenosis after lung transplantation can be safely and successfully treated using endobronchial metal stenting, with tight bronchoscopic follow-up and maintenance.

scholarly journals Long-term follow-up of hemophiliacs with lymphocytopenia or thrombocytopenia

Blood ◽  
1985 ◽  
Vol 66 (6) ◽  
pp. 1317-1320
Author(s):  
ME Eyster ◽  
DA Whitehurst ◽  
PM Catalano ◽  
CW McMillan ◽  
SH Goodnight ◽  
...  
Keyword(s):  
Liver Disease ◽  
Factor Viii ◽  
Normal Population ◽  
Long Term Follow Up ◽  
Acquired Immunodeficiency ◽  
Generalized Lymphadenopathy ◽  
Definition Of ◽  
Immunodeficiency Syndrome

Immunologic abnormalities resembling those seen in patients with the acquired immunodeficiency syndrome (AIDS) are frequently observed in multitransfused but otherwise healthy individuals with hemophilia. To determine whether there was clinical or laboratory evidence to suggest an abnormality of immunoregulation in persons with hemophilia before the recognition of AIDS, we examined data collected by the Hemophilia Study Group from 1975 to 1979 on 1,551 patients with factor VIII deficiency. The prevalence of lymphocytopenia and thrombocytopenia in patients over 5 years of age on entry was found to be 9.3% (94/1,013) and 5.0% (26/518), respectively. These rates were significantly different from a normal population (P less than .00001 and less than .0003). No cases meeting the definition of AIDS were noted during the study. However, on follow-up in 1984 of a cohort of 79 patients with thrombocytopenia or lymphocytopenia on two or more occasions during the study, eight patients (10%) with AIDS-related abnormalities, including idiopathic thrombocytopenic purpura, non-Hodgkin's lymphoma, generalized lymphadenopathy, and oral moniliasis without obvious cause were identified. Of the 79 patients, liver disease accounted for five of the ten deaths (12.6% mortality) observed during a minimum follow-up of five years after detection of cytopenia. Only one death was attributed to bleeding in the absence of liver disease. We conclude that (a) the frequency of lymphocytopenia and thrombocytopenia was increased in multitransfused factor VIII-deficient hemophiliacs before the advent of AIDS, and (b) persistent lymphocytopenia and thrombocytopenia appear to be strongly associated with liver disease, which was the leading cause of death in a cohort of hemophiliacs followed five or more years.

Renal hypoplasia

2015 ◽  
Author(s):  
Michiel F. Schreuder
Keyword(s):  
Severe Form ◽  
Renal Hypoplasia ◽  
Renal Hypodysplasia ◽  
Long Term Follow Up ◽  
The Mean ◽  
Renal Size ◽  
Definition Of

In true renal hypoplasia, normal nephrons are formed but with a deficit in total numbers. As nephron number estimation is not possible in vivo, renal size is used as a marker. A widely used definition of renal hypoplasia is kidneys with a normal appearance on ultrasound but with a size less than two standard deviations below the mean for gender, age, and body size. A distinct and severe form of renal hypoplasia is called (congenital) oligomeganephronia, which is characterized by small but normal-shaped kidneys with a marked reduction in nephron numbers (to as low as 10–20% of normal), a distinct enlargement of glomeruli, and a reduced renal function. In many cases, the small kidney also shows signs of dysplasia on ultrasound, leading to the diagnosis of renal hypodysplasia. Based on the hyperfiltration hypothesis and clinical studies, glomerular hyperfiltration can be expected, resulting in hypertension, albuminuria, and renal injury, for which long-term follow-up of all patients with renal hypoplasia is desirable.

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