Thymic tumours and their special features

Thymic tumours are rare thoracic malignancies, that may be aggressive and difficult to treat. The pillars of the management include pathological review, consideration of differential diagnoses, staging and multidisciplinary discussion. Assessment of resectability is key to drive the treatment sequencing. Association with autoimmune diseases, especially myasthenia gravis, is observed, which impacts the oncological management. Networks are being built at the national and international levels. This article provides an overview of the most recent findings in the diagnosis, staging, histology, and management strategies of thymic tumours.

Download Full-text

A review on autoimmune diseases Myasthenia Gravis: Causes, pathogenesis, symptoms and treatment

Journal of Physics Conference Series ◽

10.1088/1742-6596/1853/1/012063 ◽

2021 ◽

Vol 1853 (1) ◽

pp. 012063

Author(s):

S A JarAllah ◽

Z S Al-Garawi

Keyword(s):

Autoimmune Diseases ◽

Myasthenia Gravis

Download Full-text

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

International Journal of Molecular Sciences ◽

10.3390/ijms21103483 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3483 ◽

Cited By ~ 1

Author(s):

Przemysław Koźmiński ◽

Paweł Krzysztof Halik ◽

Raphael Chesori ◽

Ewa Gniazdowska

Keyword(s):

Folic Acid ◽

Combination Therapy ◽

Autoimmune Diseases ◽

Myasthenia Gravis ◽

Neurological Disorders ◽

Chemotherapeutic Agent ◽

Neurological Diseases ◽

Immunosuppressive Drug ◽

Structural Analogue ◽

Potential Benefits

Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.

Download Full-text

Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands

Multiple Sclerosis Journal ◽

10.1177/13524585070130030201 ◽

2007 ◽

Vol 13 (3) ◽

pp. 332-335 ◽

Cited By ~ 19

Author(s):

M. Nakamura ◽

I. Nakashima ◽

S. Sato ◽

I. Miyazawa ◽

K. Fujihara ◽

...

Keyword(s):

Multiple Sclerosis ◽

Autoimmune Diseases ◽

Myasthenia Gravis ◽

Neuromyelitis Optica ◽

Disease Duration ◽

Sicca Syndrome ◽

Common Features ◽

Laboratory Features ◽

Oligoclonal Igg ◽

Oligoclonal Igg Bands

Of 23 neuromyelitis optica (NMO) cases, we found two cases with oligoclonal IgG bands (OBs). Both patients were positive for NMO-IgG. Their common features were long disease duration and co-existing autoimmune diseases (myasthenia gravis and sicca syndrome). Although OBs are mostly negative in NMO, which distinguishes it from multiple sclerosis (MS), they can be positive by long-standing autoimmunity, which may not be directly related to NMO. Multiple Sclerosis 2007; 13: 332-335. http://msj.sagepub.com

Download Full-text

Possible Strategies for the Treatment of Myasthenia Gravis and Other Autoimmune Diseases

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1987.tb51330.x ◽

1987 ◽

Vol 505 (1 Myasthenia Gr) ◽

pp. 610-618 ◽

Cited By ~ 4

Author(s):

G. J. V. NOSSAL

Keyword(s):

Autoimmune Diseases ◽

Myasthenia Gravis

Download Full-text

Poisoning

Oxford Handbook of Pre-hospital Care ◽

10.1093/med/9780198734949.003.0006 ◽

2020 ◽

pp. 369-458

Author(s):

Ian Greaves ◽

Keith Porter

Keyword(s):

Substance Abuse ◽

Clinical Features ◽

Management Strategies ◽

Differential Diagnoses ◽

Abused Drugs

This chapter begins by describing the approach to the poisoned patient, including airway, breathing, circulation, disability, and exposure. Differential diagnoses and those that should be excluded are explained. Diagnostic clues and symptom complexes are tabulated. Different poisons are then covered in turn, with their general and clinical features and management strategies detailed. A second section on substance abuse follows. The presentation and management of commonly abused drugs are described, alongside a dictionary of street names.

Download Full-text