Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers
2020 ◽
Vol 21
(10)
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pp. 3483
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Keyword(s):
Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.
2020 ◽
Vol 19
(7)
◽
pp. 509-526
2021 ◽
Vol 1853
(1)
◽
pp. 012063
2010 ◽
Vol 28
(1)
◽
pp. 2-8
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2018 ◽
Vol 4
(2)
◽
pp. 69-74
2007 ◽
Vol 13
(3)
◽
pp. 332-335
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1981 ◽
Vol 44
(6)
◽
pp. 469-475
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