scholarly journals Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease

2021 ◽  
pp. 00068-2021
Author(s):  
Aparna Balasubramanian ◽  
Robert J. Henderson ◽  
Nirupama Putcha ◽  
Ashraf Fawzy ◽  
Sarath Raju ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Physical Health ◽  
Pulmonary Disease ◽  
Functional Performance ◽  
Chronic Obstructive ◽  
Diffusing Capacity ◽  
Obstructive Pulmonary Disease ◽  
Sf 36

In Chronic Obstructive Pulmonary Disease (COPD), anaemia is associated with increased morbidity, but the relationship between haemoglobin over its entire observed range and morbidity is poorly understood. Such an understanding could guide future therapeutic targeting of haemoglobin in COPD management. Leveraging the COPDGene® study, we conducted a cross-sectional analysis of haemoglobin from COPD participants, examining symptoms, quality of life, functional performance, and acute exacerbations of COPD (AECOPD). Haemoglobin was analysed both as a continuous variable and categorized into anaemia, normal haemoglobin, and polycythaemia groups. Fractional polynomial modelling was used for continuous analyses; categorical models were multivariable linear or negative binomial regressions. Covariates included demographics, comorbidities, emphysema, diffusing capacity, and airflow obstruction. From 2539 participants, 366(14%) were identified as anaemic and 125(5%) as polycythaemic. Compared to normal haemoglobin, anaemia was significantly associated with increased symptoms (CAT score: p=0.006, mMRC: p=0.001), worse quality of life (SGRQ score: p<0.001, SF-36 General Health: p=0.002, SF-36 Physical Health: p<0.001), decreased functional performance (6MWD: p<0.001), and severe AECOPD (p=0.01), while polycythaemia was not. Continuous models however demonstrated increased morbidity at both ends of the haemoglobin distribution (p<0.01 for mMRC, SGRQ, SF-36 Physical Health, 6MWD, and severe AECOPD). Evaluating interactions, both diffusing capacity and haemoglobin were independently associated with morbidity. We present novel findings that haemoglobin derangements towards either extreme of the observed range are associated with increased morbidity in COPD. Further investigation is necessary to determine whether haemoglobin derangement drives morbidity or merely reflects systemic inflammation and whether correcting haemoglobin towards the normal range improves morbidity.

scholarly journals COMPARATIVE STUDY OF THE IMPACT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON THE QUALITY OF LIFE OF PATIENTS WITH PULMONARY TUBERCULOSIS BASED ON THE MOS SF-36 QUESTIONNAIRE

2021 ◽  
Vol 14 (3) ◽  
pp. 63-69
Author(s):  
MARAT F. YAUSHEV ◽  
◽  
ALEXEY P. ALEXEEV ◽  
ILGIZYAR F. MAKHMUTOV ◽  
BORIS M. PETROV ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Disease ◽  
Negative Impact ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36 ◽  
The Impact

Pulmonary tuberculosis (TBL), as well as chronic obstructive pulmonary disease (COPD), have a diverse negative impact on the quality of life (QOL) of patients. In this regard, a detailed study of the quality of life of patients with pulmonary tuberculosis in combination with chronic obstructive pulmonary disease retains its importance and relevance.

scholarly journals Evaluation of the quality of life in patients with chronic obstructive pulmonary disease in combination with cardiovascular disease.

2017 ◽  
Vol 95 (7) ◽  
pp. 629-633
Author(s):  
A. A. Nizov ◽  
V. N. Abrosimov ◽  
Anna N. Vyunova ◽  
I. B. Ponomareva
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bodily Pain ◽  
Well Being ◽  
Role Playing ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36

This article reports the results of evaluation of the quality of life in patients with chronic obstructive pulmonary disease (COPD) and its combination with coronary heart disease (CHD) or essential hypertension (HD) based on the SF-36 questionnaire designed for the non-specific assessment of the patient's quality of life and widely used in clinical studies to characterize theirgeneral well-being and the degree of satisfaction with those aspects of human activity that affect health. SF-36 consists of 36 questions, grouped into eight scales: physical functioning, role-playing activity, bodily pain, general health, vitality, social functioning, emotional well-being and mental health. The scales are combined in such a way that the higher the value (from 0 to 100) the better results of evaluation based on a given scale. They were used to derive two parameters characterizing psychological and physical components of health.

Generic versus Disease-specific Instruments in Quality-of-life Assessment of Chronic Obstructive Pulmonary Disease

2006 ◽  
Vol 45 (02) ◽  
pp. 211-215 ◽  
Author(s):  
V. Vondra ◽  
M. Malý
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Well Being ◽  
Life Assessment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36 ◽  
Disease Specific

Summary Objectives: Chronic respiratory diseases may alter a patient’s social life and well-being. Measures of health-related quality of life have been proven to bring complementary information to functional assessments. The aim of the study was to describe the questionnaires that are most frequently used to measure this subjective construct in patients with chronic obstructive pulmonary disease (COPD) and to compare the responses obtained via administering one generic (SF-36) and one disease-specific questionnaire (St. George’s Respiratory Questionnaire; SGRQ) to patients with COPD. Methods: One group of patients (46 individuals) was used to evaluate the questionnaire’s performance in repeated administrations under unchanged conditions (reproducibility) and to study the correlations of corresponding domains of respective questionnaires. Responsiveness of both questionnaires was tested on another group of 129 patients measured before and after the therapeutic stay at the spa. Methods of cor-relational analysis (Spearman, intraclass, and canonical correlation coefficients) as well as the Wilcoxon rank test were used for statistical analysis. Results: Both questionnaires seem to be comprehensive outcome measures for patients with COPD, but some particular areas may not be covered with the same intensity (e.g. emotional problems). Reproducibility of both questionnaires was good and only small non-significant shifts were seen, particularly in physical and social functioning domains. In repeated measurement, the SGRQ seemed to be slightly more responsive to change than the SF-36. Conclusions: The idea of using generic and disease-specific questionnaires together probably represents the best approach to this topic. It may improve our knowledge and explain better the relationship between disease-specific changes in patient status and both disease-specific treatment and general functional status.

The Effect of Telerehabilitation on Quality of Life, Exercise Capacity, and Spirometry Indexes in Patients with Chronic Obstructive Pulmonary Disease in Masih Daneshvari Hospital

2021 ◽  
Author(s):  
Somayeh Ghadimi ◽  
Atefeh Fakharian ◽  
Mohsen Abedi ◽  
Reyhaneh Zahiri ◽  
Mahsan Norouz Afjeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
And Control

Background: Chronic Obstructive Pulmonary Disease (COPD) leads to limited activity and reduced quality of life. Treatment of this disease is a long-term process that requires the cooperation of patients in monitoring and treatment. Methods: In the present study which was conducted from April 2019 to March 2021 in Masih Daneshvari Hospital, Tehran, Iran, 75 patients were randomly divided into telerehabilitation and control groups. Patients in the control group received pulmonary rehabilitation including respiratory, isometric, and aerobic exercises for 8 weeks, three times per week. In the second group, patients were given a lung rehabilitation booklet and asked to repeat the exercises three times a week for four weeks according to a specific schedule. In addition, patients installed Behzee care application on the mobile phone that recorded various indicators such as heart rate, SpO2, dyspnea, fatigue, and daily activities. This application reminded the patient of the program every day and at a specific time. Finally, the patients’ conditions were compared in the two groups after 8 weeks using CAT and mMRC questionnaires and 6-Minute Walk (6MW) exercise indices as well as spirometry tests. Results: In all four indicators (6MW, CAT,  and mMRC questionnaires as well as spirometry), patients showed improvement after rehabilitation (p<0.001). This improvement was significantly higher in the telemedicine group compared to the other group (p<0.01). Conclusion: The use of telerehabilitation in COPD patients is effective in improving spirometry indices, quality of life, as well as activity and sports indices.

A Correlational study on quality of life and disease severity among Chronic Obstructive Pulmonary Disease (COPD) clients attending a pulmonary Medicine OPD of a Tertiary care hospital, Kolkata

2021 ◽  
pp. 528-532
Author(s):  
Uma Rani Adhikari ◽  
Soma Roy
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Tertiary Care ◽  
Chronic Obstructive ◽  
Pulmonary Medicine ◽  
Care Hospital ◽  
Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is recently the most common chronic lung disease and presents a serious medical, economic, and social problem for people. A correlational survey research was adopted to identify relationship between quality of life and disease severity among Chronic Obstructive Pulmonary Disease (COPD) clients attending Pulmonary Medicine OPD in a selected hospital, Kolkata with the objectives to assess the quality of life of Chronic Obstructive Pulmonary Disease (COPD) clients and to find out correlation between disease severity and quality of life among Chronic Obstructive Pulmonary Disease (COPD) clients. Purposive sampling technique was adapted to select 138 Chronic Obstructive Pulmonary Disease (COPD) clients attending Pulmonary Medicine OPD in a tertiary care hospital, Kolkata. The structured interview schedule was used to collect on demographic data and standardized WHO QOL BREF tool was used to assess Quality of Life. Standardized GOLD criteria were used to assess disease severity of COPD clients. Reliability of the demographic data collection tool was established by inter- rater method and r was 0.77. All the tools were tried out before final data collection. The finding of the study revealed statistically non-significant relationship between all the domain of QOL and disease severity of COPD patients. Total Quality of Life score is also not significantly related with COPD Disease severity score. The study results also showed that QOL is not associated with sociodemographic characteristics. The study concluded that, there is no correlation between quality of life and disease severity.

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