scholarly journals Nickel allergy is associated with wheezing and asthma in a cohort of young German adults: results from the SOLAR study

2020 ◽  
Vol 6 (1) ◽  
pp. 00178-2019 ◽  
Author(s):  
Laura Kolberg ◽  
Felix Forster ◽  
Jessica Gerlich ◽  
Gudrun Weinmayr ◽  
Jon Genuneit ◽  
...  
Keyword(s):  
Contact Allergy ◽  
International Study ◽  
Potential Effect ◽  
Second Phase ◽  
Type I ◽  
Nickel Allergy ◽  
Follow Up Study ◽  
Type Iv ◽  
Incident Asthma

BackgroundNickel allergy is the most prevalent contact allergy. It belongs to a different hypersensitivity type to asthma and rhinoconjunctivitis. The aim of this analysis was to assess whether self-reported nickel allergy is associated with incident wheezing, asthma and rhinoconjunctivitis in young German adults, taking into account potential effect modification by sex.MethodsIn total, 2051 (70.6%) participants aged 19–24 years took part in the second phase of SOLAR (Study on Occupational Allergy Risks), a follow-up study of ISAAC II (the second phase of the International Study of Asthma and Allergies in Childhood) in Germany. Self-reported nickel allergy, as well as having pierced ears, and the three outcomes incident wheezing, asthma and rhinoconjunctivitis, were analysed stratified for sex. Logistic regression adjusted for potential confounders was performed.ResultsAn association between self-reported nickel allergy and incident wheezing was observed for men and women, while only in males did pierced ears show a significant association with the outcome (adjusted OR 2.26, 95% CI 1.10–4.62). Also only in males, self-reported nickel allergy was associated with elevated odds for incident asthma (adjusted OR 4.34, 95% CI 1.22–15.41). Neither in men nor in women was a significant association observed for incident rhinoconjunctivitis.ConclusionOur results suggest that self-reported nickel allergy is associated with incident wheezing. Whether this association is due to environmental or genetic predisposition, or due to an overlap of the mechanisms of type I and type IV hypersensitivity, needs to be elucidated.

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs

2020 ◽  
Vol 20 (7) ◽  
pp. 992-1002 ◽  
Author(s):  
Marta Tramontana ◽  
Leonardo Bianchi ◽  
Katharina Hansel ◽  
Daniela Agostinelli ◽  
Luca Stingeni
Keyword(s):  
Contact Dermatitis ◽  
Contact Allergy ◽  
Systemic Exposure ◽  
Prevention Programs ◽  
Nickel Allergy ◽  
Type Iv ◽  
Treatment And Prevention ◽  
Typical Type ◽  
Clinical Patterns ◽  
Allergic Contact

Nickel is the most common cause of contact allergy in the general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD). ACD from nickel is a typical type IV hypersensitivity. Nickel allergy is mostly caused by nonoccupational exposure, such as jewelry and clothing decorations, metal tools, medical devices (mainly orthopedic and orthodontic implants, cardiovascular prosthesis), eyeglasses, utensils, keys, pigment for paint, cosmetics, and food (mainly legumes, chocolate, salmon, peanuts). Occupational exposure can involve several workers (mechanics, metalworkers, platers, hairdressers, jewelers, workers in the constructions and electronic industries), classically involving hands and forearms. The classic clinical pattern of ACD caused by nickel is characterized by eczematous dermatitis involving the sites of direct contact with the metal. Non-eczematous-patterns are reported, including lichenoid dermatitis, granuloma annulare, vitiligo-like lesions, dyshidrosiform dermatitis, and vasculitis. In the case of systemic exposure to nickel, sensitized patients could develop systemic contact dermatitis. Patch testing represents the gold standard for the diagnosis of ACD from nickel. Treatment includes avoidance of contact with products containing nickel and the patient’s education about the possible use of alternative products. A recent EU nickel directive, regulating the content and release of nickel from products, has caused a decrease of nickel contact allergy in some European countries. Nickel allergy is a relevant issue of public health with significant personal, social, and economic impact. This review summarizes epidemiology, pathomechanism, clinical patterns, treatment, and prevention programs.

Mother-to-child transmission of human T-cell leukemia virus type I (HTLV-1): A fifteen-year follow-up study in Okinawa, Japan

1987 ◽  
Vol 40 (6) ◽  
pp. 755-757 ◽  
Author(s):  
Koichi Kusuhara ◽  
Shunro Sonoda ◽  
Kazuo Takahashi ◽  
Ken Tokugawa ◽  
Junichiro Fukushige ◽  
...  
Keyword(s):  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Child Transmission ◽  
Cell Leukemia Virus Type ◽  
Follow Up Study ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Mother To Child

PS01.072: IT IS NOT ALWAYS RISKY USING MESH IN THE TREATMENT OF HIATAL HERNIA

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 69-69
Author(s):  
Maximiliano Loviscek ◽  
Mauro Acosta ◽  
Oscar Crespin ◽  
Guido Orbe ◽  
Cesar Villamil ◽  
...  
Keyword(s):  
Hiatal Hernia ◽  
Conflicts Of Interest ◽  
Synthetic Mesh ◽  
Gastric Erosion ◽  
Type I ◽  
Intrathoracic Stomach ◽  
Type Iii ◽  
Type Iv ◽  
Low Incidence

Abstract Background Many studies have shown that the importance of using mesh for paraesophageal hernia repair (PEHR) is to prevent recurrence. Unfortunately, it is associated with high risk of complications such as esophageal or gastric erosion. The aim of this study is to report the results of 38 patients who underwent laparoscopic PEHR with the use of a BioSynthetic mesh (GoreÒ Bio AÒ tissue Reinforcement.USA). Methods Observational, retrospective, single-center cohort study. We analysed retrospectively 38 consecutive patients with diagnosis of symptomatic Hiatal Hernia (HH) treated laparoscopically with an absorbable BioSynthetic mesh, between 2011–2017. The classic radiologic classification was used to classify the HH before surgery. This classification consists in four types/stages (I-IV). I: Sliding HH, II: Paraesophageal HH, III: Mixed form and IV: Intrathoracic stomach—upside-down hernia. All patients with Type III—IV hiatal hernia who underwent laparoscopic PEHR using an absorbable BioSynthetic mesh were included. We evaluated the results after PEHR with a symptoms questionnaire using a score 0–4 (Likert scale) and with an esophagogram and an esophagogastroduodenoscopy (EGD) analyzing the surgical success. Success was considered with symptomatic score improvement and/or absence of any symptomatic HH at the esophagogram and/or EGD. Results 38 patients: 7 males and 31 women. Median age: 66 (range 40–71). 12/38 (31,6%) patients had a type III HH and 26/38 (68,4%) a type IV. All these patients had been treated with a laparoscopic PEHR, using an absorbable BioSynthetic mesh as a reinforcement of the crura and Nissen fundoplication. The median follow-up was 12 months. 16/38 (42%) had a follow-up > 24 months. Success was evident in 95% of the patients. We observed 2 recurrences, one with a symptomatic type I HH and the other with an early type III HH recurrence. Conclusion The use of an absorbable synthetic mesh as a reinforcement of the crura in the treatment of the PEH has encouraging good results in the mild term follow up, with an extremely low incidence of complications. Disclosure All authors have declared no conflicts of interest.

Recent Modifications in Thyroplasty Type I

1989 ◽  
Vol 98 (10) ◽  
pp. 777-779 ◽  
Author(s):  
Nobuhiko Isshiki ◽  
Hisayoshi Kojima ◽  
Tatsuzo Taira ◽  
Kazuhiko Shoji
Keyword(s):  
Soft Tissue ◽  
Vocal Cord ◽  
Type I ◽  
Minimal Intervention ◽  
Follow Up Study ◽  
Calcified Cartilage ◽  
Definition Of ◽  
Made In

Among thyroplasties, type I is the most frequently used for medialization of the vocal cord. Follow-up study on patients indicated that reversion of voice can occur after operation. Revision was done in five cases with improvement of voice. On the basis of this experience, modifications were made in the technique of thyroplasty type I. They include 1) cutting the calcified cartilage with minimal intervention in the soft tissue, 2) fixation of the window with a silicone plug to enhance medialization, and 3) overmedialization of the vocal cord and definition of criteria for it that can be used during surgery.

Persistence of contact allergy among Danish adults: an 8-year follow-up study

2001 ◽  
Vol 45 (6) ◽  
pp. 350-353 ◽  
Author(s):  
N. H Nielsen ◽  
A Linneberg ◽  
T Menné ◽  
F Madsen ◽  
L Frølund ◽  
...  
Keyword(s):  
Contact Allergy ◽  
Follow Up Study
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