scholarly journals Protein kinase G type-I phosphorylates c-Src at serine-17 and promotes cell survival, proliferation and attachment in human mesothelioma and non-small cell lung cancer cells

2011 ◽  
Vol 11 (S1) ◽  
Author(s):  
Ronald R Fiscus ◽  
Mary G Johlfs
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Small Cell Lung Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Protein Kinase G ◽  
Type I ◽  
Small Cell Lung

Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells

2013 ◽  
Vol 85 (3) ◽  
pp. 426-438 ◽  
Author(s):  
Eva A.M. Schaefer ◽  
Stefanie Stohr ◽  
Michael Meister ◽  
Achim Aigner ◽  
Thomas Gudermann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Cation Channel ◽  
Toxic Substances ◽  
Small Cell Lung ◽  
Stimulation Of

scholarly journals Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells

2009 ◽  
Vol 8 (17) ◽  
pp. 1671-1679 ◽  
Author(s):  
Jingchun Gao ◽  
Zhong Zheng ◽  
Bhupendra Rawal ◽  
Michael J. Schell ◽  
Gerold Bepler ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Therapeutic Target ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Novel Therapeutic

scholarly journals Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p/TGFBR1 pathway

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xinhua Lu ◽  
Chenyang Xu ◽  
Zhexuan Xu ◽  
Chunya Lu ◽  
Rui Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Transforming Growth Factor ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Luciferase Reporter ◽  
Type I ◽  
Small Cell Lung

Abstract Background Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor growth and metastasis. However, whether it affects lung cancer cells remains unclear. Methods We assessed the effects of PL on the proliferation and apoptosis of A549 and H1299 NSCLC cell lines. Results PL was mildly toxic to normal human bronchial epithelial cells and significantly suppressed growth and facilitated apoptosis of A549 and H1299 cells. It also upregulated microRNA (miR)-34b-3p and downregulated the transforming growth factor beta type I receptor (TGFBR1). The dual-luciferase reporter assay showed that TGFBR1 is a target gene of miR-34b-3p. Silencing of miR-34b-3p or overexpression of TGFBR1 partially attenuated the effects of PL on A549 and H1299 cells. Conclusions PL inhibits proliferation and induces apoptosis of A549 and H1299 cells by upregulating miR-34b-3p and modulating TGFBR1 signaling pathway.

Sign in / Sign up

Export Citation Format

Share Document