scholarly journals Attenuation by a novel synthetic analogue of ACTH4-7 of the learning and memory deficits in juvenile rats treated with amphetamine in utero: role of nitric oxide

2009 ◽  
Vol 9 (Suppl 2) ◽  
pp. A26
Author(s):  
Valentina Bashkatova ◽  
Sergey Sudakov ◽  
Darya Rezvanova ◽  
Helmut Prast ◽  
Anatoly Vanin
Keyword(s):  
Nitric Oxide ◽  
Learning And Memory ◽  
Memory Deficits ◽  
In Utero ◽  
Synthetic Analogue ◽  
Juvenile Rats ◽  
Learning And Memory Deficits

scholarly journals Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kuo-Jen Wu ◽  
Ming-Tsuen Hsieh ◽  
Chi-Rei Wu ◽  
W. Gibson Wood ◽  
Yuh-Fung Chen
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Learning And Memory ◽  
Green Tea ◽  
Memory Impairment ◽  
Memory Deficits ◽  
Green Tea Extract ◽  
Morris Water Maze Test ◽  
Learning And Memory Deficits ◽  
Tea Extract

Ischemic stroke results in brain damage and behavioral deficits including memory impairment. Protective effects of green tea extract (GTex) and its major functional polyphenol (−)-epigallocatechin gallate (EGCG) on memory were examined in cerebral ischemic rats. GTex and EGCG were administered 1 hr before middle cerebral artery ligation in rats. GTex, EGCG, and pentoxifylline (PTX) significantly improved ishemic-induced memory impairment in a Morris water maze test. Malondialdehyde (MDA) levels, glutathione (GSH), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus were increased by long-term treatment with GTex and EGCG. Both compounds were also associated with reduced cerebral infraction breakdown of MDA and GSH in the hippocampus. Inin vitroexperiments, EGCG had anti-inflammatory effects in BV-2 microglia cells. EGCG inhibited lipopolysaccharide- (LPS-) induced nitric oxide production and reduced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV-2 cells. GTex and its active polyphenol EGCG improved learning and memory deficits in a cerebral ischemia animal model and such protection may be due to the reduction of oxidative stress and neuroinflammation.

The role of NF-κB in learning and memory deficits in offspring rats induced by prenatal stress

2006 ◽  
Vol 27 (1) ◽  
pp. 21-22
Author(s):  
Li Hui ◽  
Song Tianbao ◽  
Jia Ning ◽  
Bai Zhuanli ◽  
Cai Qing ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Prenatal Stress ◽  
Memory Deficits ◽  
Learning And Memory Deficits

scholarly journals Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth

Clinics ◽  
2010 ◽  
Vol 65 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
Mahmoud Hosseini ◽  
Samaneh Sadat Dastghaib ◽  
Houshang Rafatpanah ◽  
Mosa Al-Reza Hadjzadeh ◽  
Hossein Nahrevanian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Learning And Memory ◽  
Memory Deficits ◽  
Juvenile Growth ◽  
Learning And Memory Deficits

scholarly journals Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

2012 ◽  
Vol 70 (11) ◽  
pp. 874-879 ◽  
Author(s):  
Reihaneh Sadeghian ◽  
Masoud Fereidoni ◽  
Mohammad Soukhtanloo ◽  
Hamid Azizi-Malekabadi ◽  
Mahmoud Hosseini
Keyword(s):  
Nitric Oxide ◽  
Learning And Memory ◽  
Memory Deficits ◽  
Ovariectomized Rats ◽  
Estradiol Valerate ◽  
High Dose ◽  
Trial Test ◽  
Learning And Memory Deficits ◽  
Underlying Mechanisms ◽  
Nitric Oxide Metabolites

The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.

scholarly journals Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats

2017 ◽  
Vol 8 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Razieh Kooshki ◽  
Mehdi Abbasnejad ◽  
Saeed Esmaeili-Mahani ◽  
Maryam Raoof ◽  
◽  
...  
Keyword(s):  
Learning And Memory ◽  
Orofacial Pain ◽  
Memory Deficits ◽  
Research Paper ◽  
Learning And Memory Deficits
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