scholarly journals Phage lysin to control the overgrowth of normal flora in processed sputum samples for the rapid and sensitive detection of Mycobacterium tuberculosis by luciferase reporter phage assay

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Balaji Subramanyam ◽  
Gomathi Sivaramakrishnan ◽  
Azger Dusthackeer ◽  
Vanaja Kumar
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Sensitive Detection ◽  
Luciferase Reporter ◽  
Normal Flora ◽  
Phage Lysin

Rapid and Sensitive Detection of Mycobacterium tuberculosis by an Enhanced Nanobiosensor

ACS Sensors ◽  
2021 ◽  
Author(s):  
Jinbiao Ma ◽  
Manman Du ◽  
Can Wang ◽  
Xinwu Xie ◽  
Hao Wang ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Sensitive Detection

scholarly journals in silico Design, ADME Prediction, Molecular Docking, Synthesis of Novel Triazoles, Indazoles & Aminopyridines and in vitro Evaluation of Antitubercular Activity

2020 ◽  
Vol 32 (11) ◽  
pp. 2713-2721
Author(s):  
S. Triveni ◽  
C. Naresh Babu ◽  
E. Bhargav ◽  
M. Vijaya Jyothi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Docking ◽  
Drug Design ◽  
In Silico ◽  
Antitubercular Activity ◽  
Docking Studies ◽  
Luciferase Reporter ◽  
Assay Method ◽  
Adme Prediction

To design and synthesize novel triazoles, indazoles and aminopyridines from various (thiophene-2-yl)prop-2-en-1-one derivatives as antitubercular leads by in silico and in vitro methods. in silco Drug design, ADME prediction and molecular docking studies were performed to assess drug likeliness and antitubercular potential of all 30 novel triazoles, indazoles and aminopyridines. in silico Drug design studies revealed that the synthetic routes applied were appropriate according to the calculations of Swiss-ADME that measure synthetic accessibility. Most of the synthesized compounds found to have considerable binding score with enoyl ACP reductase enzyme of Mycobacterium tuberculosis. All the synthesized compounds were evaluated for antitubercular potential against Drug Resistant Mycobacterium tuberculosis H37Rv strain by Luciferase reporter assay method. Most of the synthesized compounds exhibited remarkable antitubercular potential against resistant strain.

Sign in / Sign up

Export Citation Format

Share Document