scholarly journals Exploratory study of plasma total homocysteine and its relationship to short-term outcome in acute ischaemic stroke in Nigerians

BMC Neurology ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Njideka U Okubadejo ◽  
Olajumoke O Oladipo ◽  
Adekunle A Adeyomoye ◽  
Gbolahan O Awosanya ◽  
Mustapha A Danesi
2016 ◽  
Vol 23 (3) ◽  
pp. 648-655 ◽  
Author(s):  
S. Xie ◽  
L. Lu ◽  
L. Liu ◽  
G. Bi ◽  
L. Zheng

2020 ◽  
Vol 20 (3) ◽  
pp. 103-108
Author(s):  
Agata Czarnowska ◽  
◽  
Paulina Werel ◽  
Dominika Stępień ◽  
Jacek Sajdak ◽  
...  

Aim of the study: The aim of our study was to analyse the obesity indicators [body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and the less-known body adiposity index (BAI)] to assess their influence on the severity and short-term outcome in both females and males after ischaemic stroke admitted over a period of 9 successive months to the Department of Neurology at the Medical University of Bialystok, Poland. Materials and methods: Based on the BMI, we divided the patients into the following groups: underweight, normal weight, overweight, and obese. The severity of stroke was evaluated by the National Institute of Health Stroke Scale (NIHSS). STATA 15 software (StataCorp, 2017) was used for statistical analysis. Results: The results demonstrated that there was no association between the BMI and changes in patient condition during hospitalisation in the stroke unit. The BAI had no clear correlation with the short-term outcome. However, a comparison of accuracy revealed that the BAI was a more precise indicator, and could better predict NIHSS improvement over treatment than the BMI. Among the analysed indicators, only the WC correlated with the difference between the NIHSS scores on admission and at hospital discharge. Conclusions: The BMI, used in clinical practice for decades, is far from a precise predictor of functional outcome after ischaemic stroke. This is the first study that takes into account the obesity indicator BAI in patients after acute ischaemic stroke. According to our results, in the future we should focus more attention on abdominal adiposity indicators such as the BAI or WC.


2015 ◽  
Vol 263 (1) ◽  
pp. 150-156 ◽  
Author(s):  
Markus Kneihsl ◽  
Christian Enzinger ◽  
Gerit Wünsch ◽  
Michael Khalil ◽  
Valeriu Culea ◽  
...  

2011 ◽  
Vol 105 (03) ◽  
pp. 430-434 ◽  
Author(s):  
Elim Cheung ◽  
Lonneke de Lau ◽  
Heleen den Hertog ◽  
Frank Leebeek ◽  
Diederik Dippel ◽  
...  

SummaryFibrinogen γ’ (γ’) is a natural isoform of fibrinogen, and alters the rate of formation and the properties of clots. It could therefore affect outcome after ischaemic stroke. The prognostic significance of γ’ fibrinogen levels is, however, still unclear. It was the objective of this study to assess levels of γ’ in ischaemic stroke, and its association with short-term outcome. We included 200 ischaemic stroke patients and 156 control persons. Total fibrinogen and γ’ levels were measured; outcome at discharge was assessed by means of the modified Rankin Scale score (defined as unfavourable when >2). We compared levels between patients and controls using multiple linear regression analysis, and logistic regression analysis was used to assess the relationship between levels and outcome. All analyses were adjusted for age and sex. Mean γ’ levels were significantly higher in patients with ischaemic stroke than in controls (0.37 vs. 0.32 g/l, p<0.001), and patients also had a higher γ’/total fibrinogen ratio (0.102 vs. 0.096, p=0.19). The γ’/total fibrinogen ratio is associated with unfavourable outcome in patients with ischaemic stroke (odds ratio per unit increase of γ’/total fibrinogen ratio 1.27, 95% confidence interval 1.09–1.47). Our study shows that patients with ischaemic stroke have increased levels of fibrinogen γ’ and suggests a trend towards an increased γ’/total fibrinogen ratio in ischaemic stroke. Increased fibrinogen γ’ relative to total fibrinogen levels are associated with unfavourable outcome in the early phase after stroke.


2011 ◽  
Vol 18 (2) ◽  
pp. 232-239 ◽  
Author(s):  
E. Kumral ◽  
F. Polat ◽  
H. Güllüoglu ◽  
C. Uzunköprü ◽  
R. Tuncel ◽  
...  

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