Relationship between admission serum C-reactive protein and short term outcome following acute ischaemic stroke at a tertiary health institution in Nigeria

Abstract Background Secondary loss of response to biological therapy is a challenge when treating Crohn’s disease (CD) and ulcerative colitis (UC). Currently, no single marker has been found to be valid as a prognostic indicator of response to biologic therapy in patients with CD and UC. In this study, we aimed to assess whether disease activity after 14 weeks of biologic therapy has a prognostic impact on surgery and steroid-free remission during 6 months following completion of induction therapy. Methods In an unselected cohort study based on data from 4 national Danish health registries, we identified 493 patients with UC and 620 patients with CD who completed induction therapy with biologics from 2016 to 2019. Following induction therapy with biologics, we defined disease activity based on C-reactive protein and clinical scores of disease activity. The composite endpoint, “not being well treated,” included surgery or use of corticosteroid within 6 months following induction therapy. Results In patients with UC with disease activity following induction therapy, the adjusted odds ratio for surgery or steroid treatment during 6 months of follow-up was 3.9 (95% CI, 1.6-9.3) compared with patients without disease activity, and in patients with CD, the adjusted odds ratio was 3.6 (95% CI, 1.7-7.6). Conclusions A positive treatment response to biologic treatment after induction therapy (measured by C-reactive protein and clinical scores) predicts a better short-term outcome in patients with CD and UC.

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Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome

Metabolic Brain Disease ◽

10.1007/s11011-016-9939-2 ◽

2016 ◽

Vol 32 (2) ◽

pp. 493-502 ◽

Cited By ~ 28

Author(s):

Daniela Frizon Alfieri ◽

Márcio Francisco Lehmann ◽

Sayonara Rangel Oliveira ◽

Tamires Flauzino ◽

Francieli Delongui ◽

...

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Vitamin D Deficiency ◽

C Reactive Protein ◽

Short Term ◽

Term Outcome ◽

Reactive Protein ◽

Short Term Outcome

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Effect Of Admission Hyperglycaemia On Short-Term Outcome In Adult Nigerians With A First Acute Ischaemic Stroke

African Journal of Neurological Sciences ◽

10.4314/ajns.v26i2.7598 ◽

2008 ◽

Vol 26 (2) ◽

Author(s):

K Wahab ◽

N Okubadejo ◽

F Ojini ◽

M Danesi

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Progranulin and short‐term outcome in patients with acute ischaemic stroke

European Journal of Neurology ◽

10.1111/ene.12920 ◽

2016 ◽

Vol 23 (3) ◽

pp. 648-655 ◽

Cited By ~ 8

Author(s):

S. Xie ◽

L. Lu ◽

L. Liu ◽

G. Bi ◽

L. Zheng

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study

ERJ Open Research ◽

10.1183/23120541.00014-2019 ◽

2019 ◽

Vol 5 (1) ◽

pp. 00014-2019 ◽

Cited By ~ 3

Author(s):

William W. Siljan ◽

Jan C. Holter ◽

Annika E. Michelsen ◽

Ståle H. Nymo ◽

Trine Lauritzen ◽

...

Keyword(s):

Hospital Admission ◽

Community Acquired Pneumonia ◽

C Reactive Protein ◽

Short Term ◽

Term Outcome ◽

Reactive Protein ◽

Short Term Outcome ◽

Bacterial Aetiology ◽

All Cause Mortality

BackgroundBiomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis in community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) and calprotectin levels, and plasma pentraxin 3 (PTX3) and presepsin levels, along with whole-blood white cell counts, at three time-points, and examined their association with microbial aetiology and adverse clinical outcomes in CAP.MethodsBlood samples were obtained at hospital admission, clinical stabilisation and 6-week follow-up from 267 hospitalised adults with CAP. Adverse short-term outcome was defined as intensive care unit admission and 30-day mortality. Long-term outcome was evaluated as 5-year all-cause mortality.ResultsPeak levels of all biomarkers were seen at hospital admission. Increased admission levels of C-reactive protein, PCT and calprotectin were associated with bacterial aetiology of CAP, while increased admission levels of PCT, PTX3 and presepsin were associated with adverse short-term outcome. In univariate and multivariate regression models, white blood cells and calprotectin at 6-week follow-up were predictors of 5-year all-cause mortality.ConclusionsCalprotectin emerges as both a potential early marker of bacterial aetiology and a predictor for 5-year all-cause mortality in CAP, whereas PCT, PTX3 and presepsin may predict short-term outcome.

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A STUDY ON THE ROLE OF SERUM CALCIUM ALBUMIN AND URIC ACID AS PREDICTOR OF NEUROLOGICAL SEVERITY AND SHORT-TERM OUTCOME IN ACUTE ISCHAEMIC STROKE

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2017/782 ◽

2017 ◽

Vol 4 (65) ◽

pp. 3915-3920

Author(s):

Siva Subramanyam S ◽

Ramesh Basavaiah

Keyword(s):

Uric Acid ◽

Ischaemic Stroke ◽

Serum Calcium ◽

Acute Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Body mass index, waist-to-hip ratio, and body surface area in patients with acute ischaemic stroke in north-eastern Poland

Aktualności Neurologiczne ◽

10.15557/an.2020.0013 ◽

2020 ◽

Vol 20 (3) ◽

pp. 103-108

Author(s):

Agata Czarnowska ◽

◽

Paulina Werel ◽

Dominika Stępień ◽

Jacek Sajdak ◽

...

Keyword(s):

Body Mass Index ◽

Ischaemic Stroke ◽

Body Mass ◽

Acute Ischaemic Stroke ◽

Normal Weight ◽

Clear Correlation ◽

Short Term ◽

Term Outcome ◽

Waist To Hip Ratio ◽

Short Term Outcome

Aim of the study: The aim of our study was to analyse the obesity indicators [body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and the less-known body adiposity index (BAI)] to assess their influence on the severity and short-term outcome in both females and males after ischaemic stroke admitted over a period of 9 successive months to the Department of Neurology at the Medical University of Bialystok, Poland. Materials and methods: Based on the BMI, we divided the patients into the following groups: underweight, normal weight, overweight, and obese. The severity of stroke was evaluated by the National Institute of Health Stroke Scale (NIHSS). STATA 15 software (StataCorp, 2017) was used for statistical analysis. Results: The results demonstrated that there was no association between the BMI and changes in patient condition during hospitalisation in the stroke unit. The BAI had no clear correlation with the short-term outcome. However, a comparison of accuracy revealed that the BAI was a more precise indicator, and could better predict NIHSS improvement over treatment than the BMI. Among the analysed indicators, only the WC correlated with the difference between the NIHSS scores on admission and at hospital discharge. Conclusions: The BMI, used in clinical practice for decades, is far from a precise predictor of functional outcome after ischaemic stroke. This is the first study that takes into account the obesity indicator BAI in patients after acute ischaemic stroke. According to our results, in the future we should focus more attention on abdominal adiposity indicators such as the BAI or WC.

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