scholarly journals Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Julie Lafontaine ◽  
Guergana Tchakarska ◽  
Francis Rodier ◽  
Anne-Marie Mes-Masson
Keyword(s):  
Cell Survival ◽  
Genotoxic Stress ◽  
Human Cells ◽  
Radiation Induced ◽  
Proliferative Cell

scholarly journals Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

2009 ◽  
Vol 124 (7) ◽  
pp. 1675-1684 ◽  
Author(s):  
Vinita Singh-Gupta ◽  
Hao Zhang ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
Julian J. Raffoul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells ◽  
Survival Pathway ◽  
Radiation Induced

Gene transfer by means of cell fusion I. Statistical mapping of the human X-chromosome by analysis of radiation-induced gene segregation

1977 ◽  
Vol 25 (1) ◽  
pp. 17-37
Author(s):  
S.J. Goss ◽  
H. Harris
Keyword(s):  
Gene Transfer ◽  
Genetic Mapping ◽  
Cell Fusion ◽  
X Chromosome ◽  
Human Cells ◽  
Hybrid Cells ◽  
Gene Segregation ◽  
Radiation Induced ◽  
Chromosome Exchanges ◽  
Lethal Doses

Hybrid cells were obtained by virus-induced fusion of hamster cells with irradiated human cells. The analysis of such hybrids permits a study of the effects of lethal doses of radiation on human cells and provides a method of sub-chromosomal genetic mapping that is independent of karyological analysis. Radiation-induced chromosome exchanges are shown to be extremely localized, and a map of 4 X-linked genes is presented.

scholarly journals Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

1996 ◽  
Vol 134 (4) ◽  
pp. 963-970 ◽  
Author(s):  
P Jin ◽  
Y Gu ◽  
D O Morgan
Keyword(s):  
Dna Damage ◽  
Chromatin Condensation ◽  
S Phase ◽  
Human Cells ◽  
G2 Arrest ◽  
Hela Cell Lines ◽  
Radiation Induced ◽  
G2 Delay ◽  
In Cells

The activity of the mitosis-promoting kinase CDC2-cyclin B is normally suppressed in S phase and G2 by inhibitory phosphorylation at Thr14 and Tyr15. This work explores the possibility that these phosphorylations are responsible for the G2 arrest that occurs in human cells after DNA damage. HeLa cell lines were established in which CDC2AF, a mutant that cannot be phosphorylated at Thr14 and Tyr15, was expressed from a tetracycline-repressible promoter. Expression of CDC2AF did not induce mitotic events in cells arrested at the beginning of S phase with DNA synthesis inhibitors, but induced low levels of premature chromatin condensation in cells progressing through S phase and G2. Expression of CDC2AF greatly reduced the G2 delay that resulted when cells were X-irradiated in S phase. However, a significant G2 delay was still observed and was accompanied by high CDC2-associated kinase activity. Expression of wild-type CDC2, or the related kinase CDK2AF, had no effect on the radiation-induced delay. Thus, inhibitory phosphorylation of CDC2, as well as additional undefined mechanisms, delay mitosis after DNA damage.

scholarly journals Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress

2013 ◽  
Vol 32 (24) ◽  
pp. 3192-3205 ◽  
Author(s):  
Jonathan Chang ◽  
Brandi N Davis-Dusenbery ◽  
Risa Kashima ◽  
Xuan Jiang ◽  
Nisha Marathe ◽  
...  
Keyword(s):  
Cell Survival ◽  
Genotoxic Stress ◽  
Mirna Processing

Ionizing radiation-induced instant pairing of heterochromatin of homologous chromosomes in human cells

2004 ◽  
Vol 104 (1-4) ◽  
pp. 193-199 ◽  
Author(s):  
H.I. Abdel-Halim ◽  
S.A. Imam ◽  
F.M. Badr ◽  
A.T. Natarajan ◽  
L.H.F. Mullenders ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Cells ◽  
Homologous Chromosomes ◽  
Radiation Induced
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