scholarly journals A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Soroush Nasri ◽  
Helen More ◽  
Francesco Graziano ◽  
Annamaria Ruzzo ◽  
Emily Wilson ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Diffuse Gastric Cancer ◽  
Italian Population ◽  
Susceptibility Variant ◽  
Intron 2 ◽  
Control Study ◽  
E Cadherin

scholarly journals Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanhua Wu ◽  
Zhifang Jia ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Xing Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Distant Metastasis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Prognosis ◽  
Radical Operation ◽  
Risk Of Death ◽  
Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibility: a case–control study

Tumor Biology ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 12059-12067 ◽  
Author(s):  
Suresh Govatati ◽  
Gopi Krishna Singamsetty ◽  
Nayudu Nallabelli ◽  
Sravanthi Malempati ◽  
Pasupuleti Sreenivasa Rao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cyclin D1 ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Control Study ◽  
E Cadherin

TGFBR1tagging SNPs and gastric cancer susceptibility: A two-stage case-control study in chinese population

2012 ◽  
Vol 53 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Jianjian Chen ◽  
Lin Miao ◽  
Guangfu Jin ◽  
Chuanli Ren ◽  
Qiao Ke ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Two Stage ◽  
Control Study

scholarly journals Association of CDH1 -160 C → A and -347 G→ GA polymorphisms and expression of E-cadherin and gastric cancer: A case-control study

2021 ◽  
Vol 37 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Adem Akçakaya ◽  
Nurcan Ünver ◽  
Tuğba Aydoğan Kiriş ◽  
Mehmet Güzel ◽  
Fatma Betül Akçakaya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Demographic Data ◽  
Survival Rates ◽  
Case Control ◽  
Loss Of Function ◽  
Group A ◽  
Gastric Cancer Patients ◽  
Control Study ◽  
E Cadherin

Objective: The loss of function of the E-cadherin (CDH1) gene with -160 C→A and -347 G→GA polymorphisms is regarded as a critical step for gastric cancer. It was aimed to investigate possible association of these polymorphisms and immunoexpression of E-cadherin with gastric cancer. Material and Methods: Gastric adenocarcinoma patients and individuals with benign gastric pathologies were included in this case-control study. Demographic data and pathological findings were recorded. Immunohistochemical staining of E-cadherin expression and analysis of -160 C→A and -347 G→GA polymorphisms were done. Differences between allele frequencies of -160 C→A and -347 G→GA polymorphisms and expression of E-cadherin were the primary outcomes. Results: There were 78 gastric cancer patients (Group A) and 113 individuals with benign gastric pathologies (Group B). The number of male patients and mean age were higher in Group A (p< 0.001). -160 C→A and 347 G→GA polymorphisms and their allelic distributions showed no difference between the groups (p> 0.05 for all). There was a significant association between -160 C→A polymorphism and grade of E-cadherin expression (p= 0.013). There were no significant differences between survival rates with -160 C→A, 347 G→GA and intensity of E-cadherin expression (p> 0.05 for all). There was no significant association between -160 C→A and -347 G→GA polymorphisms and gastric cancer. Conclusion: There was no impact of E-cadherin expression on tumoral features and survival in gastric cancer. -160 C→A polymorphism may influence the expression of E-cadherin in gastric cancer.

scholarly journals The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

2021 ◽  
Vol 11 ◽  
Author(s):  
Xueren Gao ◽  
Xianyang Li ◽  
Shulong Zhang ◽  
Xiaoting Wang
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Direct Sequencing ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study ◽  
Increased Susceptibility ◽  
Cancer Bioinformatics

Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.

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