scholarly journals The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

2021 ◽  
Vol 11 ◽  
Author(s):  
Xueren Gao ◽  
Xianyang Li ◽  
Shulong Zhang ◽  
Xiaoting Wang
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Direct Sequencing ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study ◽  
Increased Susceptibility ◽  
Cancer Bioinformatics

Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.

scholarly journals Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanhua Wu ◽  
Zhifang Jia ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Xing Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Distant Metastasis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Prognosis ◽  
Radical Operation ◽  
Risk Of Death ◽  
Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

AA genotype of cyclin D1 G870A polymorphism increases breast cancer risk: Findings of a case‐control study and meta‐analysis

2019 ◽  
Vol 120 (10) ◽  
pp. 16452-16466 ◽  
Author(s):  
Naseem Akhter ◽  
Faisal Abdulrahman Alzahrani ◽  
Sajad Ahmad Dar ◽  
Mohd Wahid ◽  
Real Sumayya Abdul Sattar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cyclin D1 ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

scholarly journals The correlation of microRNA-499 rs3746444 T>C locus with the susceptibility of gastric cancer: From a case-control study to a meta-analysis

2020 ◽  
Author(s):  
Guoxiang Rong ◽  
Yongping Zhu ◽  
Weifeng Tang ◽  
Hao Qiu ◽  
Sheng Zhang
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Recessive Model ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
The Relationship ◽  
Allele Model ◽  
Control Study

The relationship between rs3746444 T>C single nucleotide polymorphism (SNP) in microRNA (mir)-499 and risk of gastric cancer (GC) has been widely investigated. However, the association was still unconfirmed. Here, we first recruited 490 GC patients and 1,476 controls, and conducted a case-control study. And we did not find any association between rs3746444 T>C SNP polymorphism and risk of GC. Subsequently, we conducted a meta-analysis to explore the association of mir-499 rs3746444 polymorphism with GC development. Two authors searched the PubMed and EMBASE databases up to October 15, 2019 independently. Finally, nine literatures involving 12 independent studies were included. In total, 3,954 GC cases and 9,745 controls were recruited for meta-analysis. The results suggested that allele model, homozygote model and recessive model could increase the risk of overall GC (P = 0.002, 0.009 and 0.013, respectively). When we excluded the studies violated HWE, this association was also found in allele model (P = 0.020) and dominant model (P = 0.044). In subgroup analyses, we identified that rs3746444 SNP in mir-499 increased the risk of GC in Asians and gastric cardiac adenocarcinoma (GCA) subgroups. No significant bias of selection was found (all P>0.1). Test of sensitivity analysis indicated that our findings were stable. Additionally, we found that the power value was 0.891 in the allele model, suggesting the reliability of our findings. In summary, our analysis confirmed the association between rs3746444 and the risk of GC, especially in Asians and in patients with GCA.

scholarly journals LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

2020 ◽  
Author(s):  
Yi Zheng ◽  
Meng Wang ◽  
Shuqian Wang ◽  
Peng Xu ◽  
Yujiao Deng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Structure Prediction ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Statistical Significance ◽  
Case Control ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Control Study

Abstract Background: LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods: This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results: Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer (GG vs. TT: OR(95%) = 0.67(0.45-0.99), P = 0.042; GG vs. TT + TG: OR(95%) = 0.69(0.48-0.99), P = 0.046), especially for women aged <=49 (GG vs. TT: OR(95%) = 0.40(0.22-0.73), P = 0.02). Comparison between case groups showed genotype GG and TG/GG of rs3087918 were correlated with her-2 receptor expression (GG vs. TT: OR(95%) = 2.37(1.24-4.63), P = 0.010; TG + GG vs. TT: OR(95%) = 1.50(1.01-2.24), P = 0.045). We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated that rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions: MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG may increase the risk of breast cancer.

scholarly journals Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study

2013 ◽  
Vol 35 (12) ◽  
pp. 569-574 ◽  
Author(s):  
Lia Gonçalves Possuelo ◽  
Camila Farias Peraça ◽  
Michelle Fraga Eisenhardt ◽  
Marcelo Luis Dotto ◽  
Lucas Cappelletti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Case Control ◽  
Control Study
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