In this article, we provide the experiences of three novice public health researchers conducting studies with several vulnerable populations: women, people with disabilities, and children. We describe all phases of our interview studies including developing data collection guides, planning the interview in an appropriate setting, conducting the interviews, and bringing the interview to a close. Specific components of the interviews that are discussed include establishing rapport and minimizing the power imbalance inherent between interviewer and interviewee, including the added power imbalance that vulnerable populations experience. Issues of maintaining quality and rigor, as well as ethical considerations for working with our specific populations are also discussed.