Histological validation of carotid plaque characterization by in-vivo T2 mapping in patients with recent cerebrovascular events: preliminary results

Abstract Introduction The association of carotid plaque inflammation with cerebrovascular events is a matter of rigorous research. Microwave Radiometry (MWR) allows in vivo noninvasive measurement of the internal temperatures of tissues, reflecting inflammation. Purpose To investigate whether increased carotid temperatures in patients with documented coronary artery disease (CAD) are associated with cerebrovascular events. Methods Consecutive patients with significant CAD from three tertiary centers were included in the study. Maximum carotid plaque thickness was assessed in all carotids by ultrasound. ΔT by MWR was assigned as the temperature difference (maximal minus minimum) along the carotid artery. ΔT ≥0.90°C was assigned as high ΔT. All patients were followed-up clinically for two years and all strokes were adjudicated by an independent committee. Transient ischemic attacks were excluded. Results In total 300 patients were included in the study. High ΔT temperatures bilaterally were measured in 47 patients (15.7%). Three patients (1.0%) suffered a stroke, including one fatal. Stoke rate was 4.3% in the group with bilateral high ΔT and 0.4% in non-high ΔT group (p=0.02). In Kaplan-Meier plot patients with bilateral high ΔT showed higher stroke rate (log-rank p=0.004, figure) Conclusions Bilateral high carotid temperatures are associated with increased two-year stroke rate. The potential value of the present finding in risk stratification of intermediate carotid stenosis mandates further investigation.

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In-vivo carotid T2 mapping can accurately quantify plaque lipid content to discriminate between symptomatic and asymptomatic patients: histological validation, scan-rescan reproducibility and clinical study

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/1532-429x-18-s1-w10 ◽

2016 ◽

Vol 18 (S1) ◽

Author(s):

Luca Biasiolli ◽

Joshua T Chai ◽

Linqing Li ◽

Ashok Handa ◽

Peter Jezzard ◽

...

Keyword(s):

Clinical Study ◽

Lipid Content ◽

T2 Mapping ◽

Asymptomatic Patients ◽

Histological Validation

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Carotid Plaque Characterization with Contrast-Enhanced Ultrasound Imaging and its Histological Validation

Journal for Vascular Ultrasound ◽

10.1177/154431671003400402 ◽

2010 ◽

Vol 34 (4) ◽

pp. 175-184 ◽

Cited By ~ 4

Author(s):

Filippo Molinari ◽

William Liboni ◽

Pierangela Giustetto ◽

Enrica Pavanelli ◽

Andrea Marsico ◽

...

Keyword(s):

Ultrasound Imaging ◽

Carotid Plaque ◽

Contrast Enhanced Ultrasound ◽

Plaque Characterization ◽

Contrast Enhanced ◽

Histological Validation

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237 IN-VIVO QUANTITATIVE T2 MAPPING OF CAROTID PLAQUES IN PATIENTS WITH RECENT CEREBROVASCULAR EVENTS: AHA PLAQUE TYPE CLASSIFICATION AND CORRELATION WITH PLAQUE HISTOLOGY

Heart ◽

10.1136/heartjnl-2013-304019.237 ◽

2013 ◽

Vol 99 (suppl 2) ◽

pp. A127.1-A127

Author(s):

L Biasiolli ◽

J Chai ◽

A Lindsay ◽

A Handa ◽

M Robson ◽

...

Keyword(s):

T2 Mapping ◽

Carotid Plaques ◽

Plaque Type ◽

Cerebrovascular Events ◽

Type Classification

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395 CLINICAL POTENTIAL OF IN-VIVO BIOCHEMICAL 7.0 TESLA MR – PRELIMINARY RESULTS OF DGEMRIC ZONAL T2 AND T2* MAPPING OF ARTICULAR CARTILAGE

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(08)60436-7 ◽

2008 ◽

Vol 16 ◽

pp. S171-S172

Author(s):

G.H. Welsch ◽

T.C. Mamisch ◽

T. Hughes ◽

M. Schweitzer ◽

S. Quirbach ◽

...

Keyword(s):

Articular Cartilage ◽

T2 Mapping ◽

Preliminary Results ◽

Clinical Potential

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PERFUSION OF OVARIES IN VITRO AND IN VIVO

Acta Endocrinologica ◽

10.1530/acta.0.069s285 ◽

1972 ◽

Vol 68 (2_Supplb) ◽

pp. S285-S309 ◽

Cited By ~ 5

Author(s):

Kurt Ahrén ◽

Per Olof Janson ◽

Gunnar Selstam

Keyword(s):

Perfusion System ◽

Perfusion Technique ◽

Preliminary Results ◽

Advantages And Disadvantages

ABSTRACT This paper discusses in vivo and in vitro ovarian perfusion systems described so far in the literature. The interest is not focussed primarily on the results of these studies but rather on the advantages and disadvantages of the techniques and methods used. Another part of the paper summarizes the points which are most important, in our opinion, to take into consideration when developing an in vitro perfusion technique of the ovary. The last part of the paper gives a description of and some preliminary results from an in vitro perfusion system of the rabbit ovary which is under development in this laboratory.

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Plant-Derived Extracellular Vesicles: Current Findings,Challenges, and Future Applications

Membranes ◽

10.3390/membranes11060411 ◽

2021 ◽

Vol 11 (6) ◽

pp. 411

Author(s):

Nader Kameli ◽

Anya Dragojlovic-Kerkache ◽

Paul Savelkoul ◽

Frank R. Stassen

Keyword(s):

Human Health ◽

Extracellular Vesicles ◽

Preliminary Results ◽

In Vivo Experiments ◽

Health And Disease ◽

Conducting Research ◽

Protocol Standardization ◽

Insight Into

In recent years, plant-derived extracellular vesicles (PDEVs) have gained the interest of many experts in fields such as microbiology and immunology, and research in this field has exponentially increased. These nano-sized particles have provided researchers with a number of interesting findings, making their application in human health and disease very promising. Both in vitro and in vivo experiments have shown that PDEVs can exhibit a multitude of effects, suggesting that these vesicles may have many potential future applications, including therapeutics and nano-delivery of compounds. While the preliminary results are promising, there are still some challenges to face, such as a lack of protocol standardization, as well as knowledge gaps that need to be filled. This review aims to discuss various aspects of PDEV knowledge, including their preliminary findings, challenges, and future uses, giving insight into the complexity of conducting research in this field.

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