scholarly journals Pulmonary blood volume variation indexed to stroke volume and perfusion gradients: novel diagnostic tools in heart failure

2016 ◽  
Vol 18 (S1) ◽  
Author(s):  
Mariam Al-Mashat ◽  
Mikael Kanski ◽  
Jonas Jögi ◽  
Håkan Arheden
Keyword(s):  
Heart Failure ◽  
Stroke Volume ◽  
Blood Volume ◽  
Diagnostic Tools ◽  
Pulmonary Blood Volume ◽  
Volume Variation

scholarly journals Pulmonary Blood Volume Variation Decreases after Myocardial Infarction in Pigs: A Quantitative and Noninvasive MR Imaging Measure of Heart Failure

Radiology ◽  
2010 ◽  
Vol 256 (2) ◽  
pp. 415-423 ◽  
Author(s):  
Martin Ugander ◽  
Mikael Kanski ◽  
Henrik Engblom ◽  
Matthias Götberg ◽  
Göran K. Olivecrona ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Mr Imaging ◽  
Blood Volume ◽  
Pulmonary Blood Volume ◽  
Volume Variation

scholarly journals Increased pulmonary blood volume variation in patients with heart failure compared to healthy controls: a noninvasive, quantitative measure of heart failure

2020 ◽  
Vol 128 (2) ◽  
pp. 324-337
Author(s):  
Mariam Al-Mashat ◽  
Jonas Jögi ◽  
Marcus Carlsson ◽  
Rasmus Borgquist ◽  
Ellen Ostenfeld ◽  
...  
Keyword(s):  
Heart Failure ◽  
Phase Shift ◽  
Pulmonary Artery ◽  
Blood Volume ◽  
Main Pulmonary Artery ◽  
Left Ventricular ◽  
Healthy Controls ◽  
Pulmonary Blood Volume ◽  
Volume Variation ◽  
Patients With Heart Failure

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate whether PBVV differs in patients with heart failure compared with healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated from blood flow measurements in the main pulmonary artery and a pulmonary vein, defined as the maximum difference in cumulative PBV over one heartbeat. PBVV was indexed to stroke volume (SV) in the main pulmonary artery (PBVVSV). Patients displayed higher PBVVSV than controls (58 ± 14 vs. 43 ± 7%, P < 0.001). The change in PBVVSV could be explained by left ventricular (LV) longitudinal contribution to SV ( R2 = 0.15, P = 0.02) and the phase shift between in- and outflow ( R2 = 0.31, P < 0.001) in patients. Both variables contributed to the multiple regression analysis model and predicted PBVVSV ( R2 = 0.38); however, the phase shift alone explained ~30% of the variation in PBVVSV. No correlation was found between PBVVSV and large vessel area. In conclusion, PBVVSV was higher in patients compared with controls. Approximately 40% of the variation of PBVVSV in patients can be explained by the LV longitudinal contribution to SV and the phase shift between pulmonary in- and outflow, where the phase shift alone accounts for ~30%. The remaining variation (60–70%) most likely occurs on a small vessel level. Future studies are needed to show the clinical added value of PBVVSV compared with right-heart catheterization. NEW & NOTEWORTHY This study shows that the pulmonary blood volume variation indexed to the stroke volume is higher in patients with heart failure compared with controls. The mechanisms behind this are lack of systolic suction from the left ventricular atrioventricular plane descent and increased phase shift between the in- and outflow to the pulmonary circulation (~40%), where the phase shift alone accounts for ~30%. The remaining variation (60–70%) is suggested to occur on a small vessel level.

scholarly journals Pulmonary Blood Volume in Congestive Heart Failure

Circulation ◽  
1966 ◽  
Vol 34 (2) ◽  
pp. 249-259 ◽  
Author(s):  
B. F. SCHREINER ◽  
G. W. MURPHY ◽  
P. N. YU
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Blood Volume ◽  
Pulmonary Blood Volume

Continuous recording of pulmonary blood volume: pulmonary pressure and volume changes

1959 ◽  
Vol 197 (5) ◽  
pp. 959-962 ◽  
Author(s):  
Arthur W. Lindsey ◽  
Arthur C. Guyton
Keyword(s):  
Heart Failure ◽  
Pulmonary Artery ◽  
Chest Wall ◽  
Blood Volume ◽  
Right Heart Failure ◽  
Continuous Recording ◽  
Lung Field ◽  
Left Heart ◽  
Left Heart Failure ◽  
Pulmonary Blood Volume

A method for continuous recording of pulmonary blood volume in the intact animal has been devised, utilizing the detection of I131-tagged blood from a circumscribed portion of lung field. To rule out the interference of blood in the chest wall the counts per minute (cpm) obtained from the chest wall after removing the lung at the end of the experiment were subtracted from the recorded cpm throughout the experiment. The cpm from the chest wall were found to be stable, so that it was concluded that changes in total cpm were caused by changes in pulmonary blood volume. Constriction of the ascending aorta or pulmonary artery by previously placed loops of plastic tubing produced either right or left heart failure. When left heart failure was produced acutely, the pulmonary blood volume increased an average of 79.5%±6.1 S.E. in 23 dogs. Constriction of the pulmonary artery, producing acute right heart failure, decreased the pulmonary blood volume an average of 38%±2.3 S.E. in 23 dogs.

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

1961 ◽  
Vol 1 (04) ◽  
pp. 353-379
Author(s):  
Jacques Lammerant ◽  
Norman Veall ◽  
Michel De Visscher
Keyword(s):  
Cardiac Output ◽  
Blood Volume ◽  
Normal Subjects ◽  
Published Data ◽  
Total Blood Volume ◽  
Total Blood ◽  
Pulmonary Blood Volume ◽  
Intracardiac Flow ◽  
Normal Man ◽  
Mean Circulation

Summary1. The technique for the measurement of cardiac output by external recording of the intracardiac flow of 131I labelled human serum albumin has been extended to provide a measure of the mean circulation time from right to left heart and hence a new approach to the estimation of the pulmonary blood volume.2. Values for the basal cardiac output in normal subjects and its variations with age are in good agreement with the previously published data of other workers.3. The pulmonary blood volume in normal man in the basal state was found to be 28.2 ± 0.6% of the total blood volume.4. There was no correlation between cardiac output and pulmonary blood volume in a series of normal subjects in the basal state.5. The increase in cardiac output during digestion was associated with a decrease in pulmonary blood volume equal to 6.3 ± 1.2% of the total blood volume, that is, about 280 ml.6. The increase in cardiac output during exercise was associated with a decrease in pulmonary blood volume equal to 4.5 ± 1.0% of the total blood volume, that is, about 200 ml.7. The increase in cardiac output attributed to alarm is not associated with a decrease in pulmonary blood volume, the latter may in fact be increased.8. The total blood volume is advocated as a standard of reference for studies of this type in normal subjects in preference to body weight or surface area.9. The significance of these results and the validity of the method are discussed.

Sign in / Sign up

Export Citation Format

Share Document