scholarly journals Control of neglected tropical diseases needs a long-term commitment

BMC Medicine ◽  
2010 ◽  
Vol 8 (1) ◽  
Author(s):  
Yaobi Zhang ◽  
Chad MacArthur ◽  
Likezo Mubila ◽  
Shawn Baker
2019 ◽  
Vol 113 (12) ◽  
pp. 839-844 ◽  
Author(s):  
Hannah Kuper

AbstractNeglected tropical diseases (NTDs) are a diverse group of infectious conditions that vary in their epidemiology, impact and control. They are among the most common conditions globally, affecting approximately one billion people. Many NTDs have long-term consequences, such as visual and physical impairments. As a result, people with NTDs may have difficulties in carrying out activities or participating in society—in other words, NTDs can cause disabilities. Additionally, NTDs are often strongly linked to stigma and can have mental health consequences. It is therefore important to incorporate rehabilitation within NTD programmes. Rehabilitation can be conceptualized narrowly in terms of the provision of clinical services (e.g. physiotherapy and assistive devices) or, more broadly, including efforts to improve employment, overcome stigma and enhance social participation of people with disabilities. Approximately 15% of the global population has a disability, and this large group must be considered when designing NTD programmes. Improving the inclusion of people with disabilities may require adaptations to NTD programmes, such as making them physically accessible or training staff about disability awareness. Without incorporating disability within NTD programmes, the quality of life of people with NTDs will suffer and global targets for elimination and management of NTDs will not be met.


Cardiology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Juan I. Cotella ◽  
Ana L. Sauce ◽  
Clara I. Saldarriaga ◽  
Gonzalo E. Perez ◽  
Juan M. Farina ◽  
...  

<b><i>Introduction:</i></b> Neglected tropical diseases are a group of communicable diseases that occur in tropical and subtropical conditions and are closely related to poverty and inadequate sanitation conditions. Among these entities, chikungunya remains one of the most widely spread diseases. Although the main symptoms are related to a febrile syndrome, cardiovascular (CV) involvement has been reported, with short- and long-term implications. As part of the “Neglected Tropical Diseases and other Infectious Diseases involving the Heart” (NET-Heart) Project, the aim of this review is to compile all the information available regarding CV involvement of this disease, to help healthcare providers gain knowledge in this field, and contribute to improving early diagnosis, treatment, and prevention strategies. <b><i>Methods:</i></b> We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement in conducting and reporting this systematic review. The search was conducted using MEDLINE/PubMed, SciELO, and LILACS databases to identify any relevant studies or reviews detailing an association between chikungunya and cardiac involvement published from January 1972 to May 31, 2020. <b><i>Results:</i></b> Despite its mechanism not being fully understood, CV involvement has been described as the most frequent atypical presentation of chikungunya (54.2%). Myocarditis is the most prevalent CV complication. Different rhythm disturbances have been reported in 52% of cases, whereas heart failure was reported in 15% of cases, pericarditis in 5%, and acute myocardial infarction in 2%. Overall estimated CV mortality is 10%, although in patients with other comorbidities, it may increase up to 20%. In the proper clinical setting, the presence of fever, polyarthralgia, and new-onset arrhythmia suggests chikungunya virus-related myocarditis. <b><i>Conclusion:</i></b> Although most cases are rarely fatal, CV involvement in chikungunya infection remains the most frequent atypical presentation of this disease and may have severe manifestations. Timely diagnosis and appropriate management are necessary to improve patient outcomes.


Author(s):  
Simon J Brooker ◽  
Kundai Ziumbe ◽  
Nebiyu Negussu ◽  
Siobhan Crowley ◽  
Mona Hammami

Abstract Countries have seen substantial disruptions to usual health services related to coronavirus disease 2019 and these are likely to have immediate and long-term indirect effects on many disease control programmes, including neglected tropical diseases (NTDs). The pandemic has highlighted the usefulness of mathematical modelling to understand the impacts of these disruptions and future control measures on progress towards 2030 NTD goals. The pandemic also provides an opportunity, and a practical necessity, to transform NTD programmes through innovation.


2021 ◽  
Author(s):  
Simone de Rijk ◽  
Katherine Klemperer ◽  
Delphine Depierreux ◽  
Ziruo Fu ◽  
Kirsty Mackinlay

Poverty and inequality are both the starting point, and the ultimate outcome, for most neglected tropical diseases (NTDs). As a group of 20 diseases, NTDs are typified by their prevalence among the poor, excluded, and marginalised within society. In the absence of quality healthcare provision, many NTDs lead to long term disability, disfigurement, and stigma, which in turn act to reinforce the exclusion and poverty experienced by the afflicted. The path leading to illness is often determined by a widespread lack of access to formal education, timely healthcare, adequate living conditions, employment and nutrition. The reasons for such deprivation are complicated, but ultimately reduce to a persistence of inequalities in affected regions. These inequalities can manifest differently depending on the demographic being studied: gender, ethnicity, geographic location, level of formal education, can all determine the ease with which NTDs are transmitted, diagnosed or treated. Yet, regardless of contextual differences, NTDs continue to persist because individuals within endemic regions experience a healthcare system that is, either directly or indirectly, inequitable. The healthcare system referred to in this context is not confined to simply formal healthcare settings. Rather, it encompasses local healers, community healthcare professionals or volunteers, drug administration programmes, community mental health provision, the formal education system, and, in extension, even the infrastructure that exists to physically connect individuals to their healthcare provider. Failing to ensure parity across each of these components for every citizen equates to a discriminatory healthcare system which fails to recognise the individual’s basic human right to “a standard of living adequate for the health and well-being of themselves and of their family, including food, clothing, housing and medical care and necessary social services” (Article 25- Universal Declaration of Human Rights). To ensure NTDs are managed in a way that is sustainable in the long term, the underlying societal inequalities which allow them to persist must be first understood.


2020 ◽  
Author(s):  
Cristhian David Morales-Plaza

Guarantee better clinical practices among clinicians who attend NTDs in developing countries as well as provide education in vector control in hotspot vulnerable communities


2020 ◽  
Vol 27 ◽  
Author(s):  
Kush K. Maheshwari ◽  
Debasish Bandyopadhyay

Background: Neglected tropical diseases (NTDs) affect a huge population of the world and majority of the victims belong to the poor community of the developing countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds have demonstrated potent therapeutic activity against several NTDs. Objective: There are three major objectives: (1) To discuss the causes, symptoms, and current status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, and their mechanism of actions (if known) that are being used to treat NTDs; (3) To develop general awareness on NTDs among the medicinal/health research community and beyond. Methods: The 20 NTDs have been discussed according to their alphabetic orders along with the possible heterocyclic remedies. Current status of treatment with an emphasis on the heterocyclic drugs (commercially available and investigational) has been outlined. In addition, brief discussion of the impacts of NTDs on socio-economic condition is included. Results: NTDs are often difficult to diagnose and the problem is worsened by the unhealthy hygiene, improper awareness, and inadequate healthcare in the developing countries where these diseases primarily affect poor people. The statistics include duration of suffering, numbers affected, and access to healthcare and medication. The mechanism of actions of various heterocyclic drugs, if reported, have been briefly summarized. Conclusion: Scientists and pharmaceutical corporations should allocate more resources to reveal the in-depth mechanism of actions of many heterocyclic drugs that are currently being used for the treatment of NTDs. Analysis of current heterocyclic compounds and development of new medications can help in the fight to reduce/remove the devastating effects of NTDs. An opinion-based concise review has been presented. Based on available literature, this is the first effect to present all the 20 NTDs and related heterocyclic compounds under the same umbrella.


Sign in / Sign up

Export Citation Format

Share Document