scholarly journals The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system

2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Ramiro Echeverry ◽  
Fang Wu ◽  
Woldeab B Haile ◽  
Jialing Wu ◽  
Manuel Yepes
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Neuroprotective Effect ◽  
Fibroblast Growth ◽  
Cytokine Tumor Necrosis Factor ◽  
The Central Nervous System ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK)/Fibroblast Growth Factor-Inducible 14 (Fn14) Axis in Cardiovascular Diseases: Progress and Challenges

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 405
Author(s):  
Nerea Méndez-Barbero ◽  
Carmen Gutiérrez-Muñoz ◽  
Rafael Blázquez-Serra ◽  
Jose Martín-Ventura ◽  
Luis Blanco-Colio
Keyword(s):  
Cardiovascular Diseases ◽  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Fibroblast Growth Factor ◽  
Tumor Necrosis ◽  
Fibroblast Growth ◽  
Cardiovascular Remodeling ◽  
Cytokine Tumor Necrosis Factor ◽  
Artery Disease ◽  
Necrosis Factor

Cardiovascular diseases (CVD) are the leading cause of mortality in Western countries. CVD include several pathologies, such as coronary artery disease, stroke, peripheral artery disease, and aortic aneurysm, among others. All of them are characterized by a pathological vascular remodeling in which inflammation plays a key role. Interaction between different members of the tumor necrosis factor superfamily and their cognate receptors induce several biological actions that may participate in CVD. The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its functional receptor, fibroblast growth factor-inducible 14 (Fn14), are abundantly expressed during pathological cardiovascular remodeling. The TWEAK/Fn14 axis controls a variety of cellular functions, such as proliferation, differentiation, and apoptosis, and has several biological functions, such as inflammation and fibrosis that are linked to CVD. It has been demonstrated that persistent TWEAK/Fn14 activation is involved in both vessel and heart remodeling associated with acute and chronic CVD. In this review, we summarized the role of the TWEAK/Fn14 axis during pathological cardiovascular remodeling, highlighting the cellular components and the signaling pathways that are involved in these processes.

Cellular Sources and Effects of Tumor Necrosis Factor-? on Pituitary Cells and in the Central Nervous System

1990 ◽  
Vol 594 (1 Neuropeptides) ◽  
pp. 156-168 ◽  
Author(s):  
P. RICCIARDI-CASTAGNOLI ◽  
L. PIRAMI ◽  
M. RIGHI ◽  
P. SACERDOTE ◽  
V. LOCATELLI ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Pituitary Cells ◽  
The Central Nervous System ◽  
Necrosis Factor
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