scholarly journals Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells

2012 ◽  
Vol 7 (1) ◽  
pp. 11 ◽  
Author(s):  
Chengwei He ◽  
Rong Rong ◽  
Jing Liu ◽  
Jianbo Wan ◽  
Keyuan Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Lung ◽  
Chemotherapeutic Agents ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Ros Production ◽  
Human Lung Cancer Cells

Reversal of MRP-Mediated Multidrug Resistance in Human Lung Cancer Cells by the Antiprogestatin Drug RU486

1999 ◽  
Vol 258 (3) ◽  
pp. 513-518 ◽  
Author(s):  
Léa Payen ◽  
Laurence Delugin ◽  
Arnaud Courtois ◽  
Yolande Trinquart ◽  
André Guillouzo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells

2014 ◽  
Vol 11 (1) ◽  
pp. 682-690 ◽  
Author(s):  
ZUOLIANG DONG ◽  
LI REN ◽  
LI LIN ◽  
JIANG LI ◽  
YIWEN HUANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Resistance Reversal

scholarly journals P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo

1996 ◽  
Vol 74 (12) ◽  
pp. 1929-1934 ◽  
Author(s):  
Y Abe ◽  
Y Ohnishi ◽  
M Yoshimura ◽  
E Ota ◽  
Y Ozeki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
P Glycoprotein ◽  
Human Lung Cancer Cells

scholarly journals Beclin1-induced Autophagy Abrogates Radioresistance of Lung Cancer Cells by Suppressing Osteopontin

2012 ◽  
Vol 53 (3) ◽  
pp. 422-432 ◽  
Author(s):  
Seung-Hee Chang ◽  
Arash Minai-Tehrani ◽  
Ji-Young Shin ◽  
Sungjin Park ◽  
Ji-Eun Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cells

Abstract Osteopontin (OPN) serves as an indicator of resistance to radiotherapy. However, the role of OPN in the development of acquired radioresistance in human lung cancer cells has not yet been fully elucidated. Therefore, the potential importance of OPN as a marker of lung cancer with a potential significant role in the development of radioresistance against repeated radiotherapy has prompted us to define the pathways by which OPN regulates lung cancer cell growth. In addition, autophagy has been reported to play a key role in the radiosensitization of cancer cells. Here, we report that increased OPN expression through induction of nuclear p53 following irradiation was inhibited by exogenous beclin-1 (BECN1). Our results clearly show that BECN1 gene expression led to induction of autophagy and inhibition of cancer cell growth and angiogenesis. Our results suggest that the induction of autophagy abrogated the radioresistance of the cancer cells. Interestingly, we showed that knockdown of OPN by lentivirus-mediated shRNA induced the autophagy of human lung cancer cell. Taken together, these results suggest that OPN and BECN1 can be molecular targets for overcoming radioresistance by controlling autophagy.

Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines

Phytomedicine ◽  
2014 ◽  
Vol 21 (7) ◽  
pp. 970-977 ◽  
Author(s):  
Ming-Ju Hsieh ◽  
Mu-Kuan Chen ◽  
Ya-Yen Yu ◽  
Gwo-Tarng Sheu ◽  
Hui-Ling Chiou
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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