Role of betel quid in changing oral pathology

ABSTRACT Objective To clinically evaluate various tobacco-associated lesions and to evaluate and compare the micronucleus (MN) assay in exfoliated urothelial cells in patients with smoking and smokeless tobacco-associated lesions. Materials and Methods This study was conducted in the Department of Oral Pathology and Microbiology, Mahatma Gandhi Mission's Dental College and Hospital, Navi Mumbai, from October 2012 to June 2013. One hundred cases having tobacco habits (smoking or smokeless) and clinically detectable tobacco-associated lesions were included. Exfoliated urothelial cytosmears were prepared, stained with Papanicolaou and slides were scored for MN. Results All cases (n = 100) were found to have tobaccoassociated lesions that were clinically detectable. Voided urine samples were collected from all cases (n = 100) who indulged in smoking and smokeless tobacco habit, with males (n = 71) and females (n = 29), whose ages ranged from 19 to 75 years. We observed that out of the 100 cases evaluated, 12 cases showed the presence of MN in the urine cytosmear. Of these 12 cases, n = 10 were bidi smokers and n = 2 were betel quid chewers. Owing to insufficient population of urothelial cells in the cytosmear, MN evaluation could not be statistically proved. Conclusion Although, MN score in the urothelial cells could not be statistically assessed, due to insufficient number of urothelial cells, our observations reveal that MN count seems to be increased in smokers than smokeless tobacco users. Thus, we urge the need for further studies to highlight the comparative evaluation of MN score between smokers and smokeless tobacco on urothelial cells. How to cite this article Iyer JS, Pathak J, Patel S, Poonja L, Swain N. Comparative Evaluation of Micronuclei in Exfoliated Urothelial Cells in Patients with Smoking and Smokeless Tobacco-associated Lesions: A Prospective Quantitative Study. J Contemp Dent 2015;5(2):93-97.

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Role Of Habitual Risk Factors On Oral Squamous Cell Carcinoma

Update Dental College Journal ◽

10.3329/updcj.v8i1.38409 ◽

2018 ◽

Vol 8 (1) ◽

pp. 29-35

Author(s):

Md Abdul Hannan ◽

Mohammad Asifur Rahman ◽

Shakhawat Hossain ◽

Quazi Billur Rahman

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tobacco Smoking ◽

Maxillofacial Surgery ◽

Betel Quid ◽

Mechanical Irritation

Squamous cell carcinoma is the most common oral malignancy. Betel quid, betel quid with tobacco, smoking, alcohol consumption, mechanical irritation, genetic are the most important risk factors for Oral Squamous Cell Carcinoma (OSCC). The aim of the study was to determine the role of habitual risk factors inOral Squamous Cell Carcinoma. Materials and Methods: This is a cross-sectional study for the determination of the risk factors of OSCC over 2 years period of January 2011 to December 2012. Department of Oral & Maxillofacial Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Department of Oral & Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka,National Institute of Cancer Research & Hospital (NICRH), Mohakhali, Dhaka and Health and Hope Hospital, Dhaka from January 2011 to December 2012 Results:250 patients, comprising 44% male and 56% female were included in the study. Overall mean age was 55.94±10.93 years. The patients of OSCChavemost common habit of betel quid with tobacco 124(49.6%), then betel quid with tobacco and smoking 49(19.6%), betel quid with tobacco and Gul 19(7.6%), only smoking 13(5.2%), Betel quid without tobacco and smoking 13(5.2%), betel quid without tobacco 12(5.2%), betel quid with tobacco and catechu (Khoir) 4(1.6%), betel quid with tobac- co, smoking and gul 3(1.2%), betel quid without tobacco,smoking and alcohol 2(0.8%), betel quid without tobacco and gul 2(0.8%), betel quid without tobacco, smoking and gul 1(0.4%), betel nut chewing 1(0.4%), mechanical irritation but no habit 5(2.0%) and no habitual history 2(0.8%). Conclusion: According to this study betel quid, betel quid with tobacco, gul, smoking are the important risk factors in OSCC.Update Dent. Coll. j: 2018; 8 (1): 29-35

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