The Corona virus SARS-CoV2 that causes COVID-19 has effects that until
now have not been explained. The widespread damage of SARS-CoV2, the
comorbidities in critically ill COVID-19 patients, and the symptoms of
post-COVID-19 patients show striking similarities with conditions that
are related to depletion of nitric oxide (NO) in the human body. Many of
the symptoms of the disease may be caused by acute depletion of NO by
the immune system. Patients with the highest COVID-19 burden often have
comorbidities that are related to chronic depletion of NO. Post-COVID-19
health problems may be caused by earlier depletion of NO. Successful
therapy requires sufficient NO levels. Supplementation with NO will
increase immunity, help prevent thrombosis, and improve breathing,
kidney functions, blood flow and oxygenation in patients, elderly
patients and patients with comorbidities in particular. Furthermore, NO
helps to prevent SARS-CoV2 from entering the human cell and to suppress
viral RNA production. NO is not easy to supplement. A few SARS patients
have been treated with inhaled NO with positive results, but inhaled NO
can only deliver small quantities of NO. A new therapy has been
developed to more effectively supplement NO. It combines the ingestion
of nitrates (as NO donor), N-acetylcysteine and vitamin C (promoting NO
metabolism) with electrostimulation of the muscles (to trigger the
release of NO). It is expected that this therapy can ease the most
serious symptoms of (post) COVID-19, especially for elderly and people
with comorbidities. A patent has been applied for.
The Role of Nitric Oxide in Stem/Progenitor Cells
