Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

2006 ◽  
Vol 40 (10) ◽  
pp. 540-543 ◽  
Author(s):  
E. N. Kudinova ◽  
N. F. Salakhutdinov ◽  
V. V. Fomenko ◽  
N. N. Vol’skii ◽  
O. M. Perminova ◽  
...  
Keyword(s):  
Immune System ◽  
Functional Activity ◽  
Cholesterol Biosynthesis ◽  
Resorcinol Derivative

Approaches to the study of functional activity phagocytic link immune system (review)

2016 ◽  
pp. 39-42
Author(s):  
A. A. Abdushukurov ◽  
N. Gulyamov ◽  
R. Hietov ◽  
N. Sadikova
Keyword(s):  
Immune System ◽  
Functional Activity ◽  
System Review

scholarly journals COMPLEMENT SYSTEM AS A MARKER OF IMMUNE DYSFUNCTION IN CHILDREN AUTISM SPECTRUM DISORDERS

2019 ◽  
Vol 21 (4) ◽  
pp. 773-780
Author(s):  
E. G. Cheremnykh ◽  
P. A. Ivanov ◽  
M. I. Factor ◽  
E. Yu. Chikina ◽  
S. G. Nikitina ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Immune System ◽  
Complement System ◽  
Functional Activity ◽  
Autism Spectrum ◽  
Autistic Spectrum ◽  
Healthy Donors ◽  
Spectrum Disorders ◽  
The Difference ◽  
The Complement System

It is known that functional activity of complement system depends not only on balance and concentration of components participating in formation of the system end products, but also on levels of inhibitory activities. Numerous relations with hemostasis also substantially contribute to general level of complement system activity. Changes in complement system functioning are inevitable during chronic diseases accompanied with immune system dysregulation. All mental diseases tend to be chronic and are they aggravated by patients’ immune system changes. Autism spectrum disorders in children is a group of mental disorders. Immune system dysregulation is usually detected in such patients, manifesting as excessive susceptibility to viral and bacterial infections. Therefore, the level of its functional activity is diagnostically and prognostically significant in this pathology, since the complement system is a key element of immune system.We have evaluated functional activity of complement system in patients with autistic spectrum disorders, using the method which was developed earlier. It is based on the reaction of the protozoa (Tetrahymena pyriformis) which are both targets and activators for the complement system. The complement system capacity (cSC) was used as the main parameter of complement evaluation. The half-time of protozoa survival (T50) was defined using the BioLat device for each serum specimen added at four concentrations (1/20, 1/40, 1/80, 1/160 dilution). The complement capacity was calculated as the area enclosed by influence curve of the reciprocals of T50 and the serum dilution. According to Mann–Whitney U test, the difference between patients’ and healthy volunteers’ groups was established as Z = 4.43 (by T50 at 1/160 dilution), p < 0.001 and by cSCas Z = 5.8, p < 0.001. cSC was calculated from the results obtained at each serum concentration measured. The difference between the two groups according to Mann–Whitney U test appeared to be more significant than the difference according to T50. Therefore, cSC was taken as the main characteristic of complement system function.The contribution of hemostasis plasma components to complement system functional activity level was estimated by determination of complement capacity in plasma and serum of each blood sample from 6 patients with autism spectrum disorders and 5 healthy donors. All healthy donors showed small difference between plasma and serum complement capacity, and their complement activity was higher in plasma. In patients’ group, the complement capacity levels in plasma and serum differed significantly. The cSC levels of two patients were higher in serum than in plasma, and the cSC levels of three other patients were significantly higher in plasma than in serum. Differential involvement of coagulation into the complement system activation may be indicative for the immune system dysfunction which is observed in patients with autistic spectrum disorders of different etiology.

Actuality and perspectives of a personal approach to change the immune system functional activity based on micronutrients

2020 ◽  
Vol 18 (4) ◽  
pp. 3-12
Author(s):  
V.V. Yurasov ◽  
A.R. Sadykov ◽  
I.V. Zolkina ◽  
N.R. Khasbiullina ◽  
P.B. Glagovskiy ◽  
...  
Keyword(s):  
Immune System ◽  
Functional Activity ◽  
Personal Approach

scholarly journals Nonspecific body reactivity in patients with diabetes mellitus depending on its type

2014 ◽  
Vol 18 (2 (70)) ◽  
Author(s):  
O. A. Olenovych
Keyword(s):  
Diabetes Mellitus ◽  
Immune System ◽  
Functional Activity ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Immune Defense ◽  
Diabetes Type 1 ◽  
Patients With Diabetes

According to the results of complex assessment of integral haematological coefficients the development of endogenous intoxication was revealed in case of diabetes mellitus, whose intensity depends on the type of the disease and causes immune system disorganization. The decrease of functional activity of specific immunity as well as nonspecific one in case of diabetes mellitus leads to deregulation of cellular and humoral reactions and depends on diabetes type: in diabetes type 1 the reduction of nonspecific immunoresistance is contributed by microphages, in diabetes type 2 – by macrophages, accompanied by the deficiency of specific immune defense, reliably more significant in diabetes type 2.

scholarly journals ВПЛИВ ІМУНОМОДУЛЯТОРІВ НА ПОКАЗНИКИ КЛІТИННОГО ІМУНІТЕТУ ЛОШАТ ВЕРХОВИХ ПОРІД

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 45-49
Author(s):  
I.P. Кrytsia
Keyword(s):  
T Cells ◽  
Immune System ◽  
T Lymphocytes ◽  
Functional Activity ◽  
T Helper Cells ◽  
Hematological Parameters ◽  
Immune Reactivity ◽  
T Helper ◽  
Physiological Level ◽  
Helper Cells

To maintain a body at sufficient physiological level the effective functioning of the immune system, which determines the resistance and immune reactivity of animals, is necessary. In our studies in newborn foals indicators of cellular immunity were mature. During the studying of foals of all ages were established the reduction of hematological parameters in animals months of age.The use of immunomodulators prevents the immunodeficiency in animals. Immunomodulators introduction for animals normalizes T–immune system, in particular, increases the number of leucocytes in the blood, lymphocytes of certain populations, especially teofilin–resistant subpopulation of T–helper cells, increases the functional activity of lymphocytes.Under influence of ribotan revealed a trend to the increasing of T–lymphocytes by 0.2 – 1.2% (0.4 – 2.3%), respectively in Purebred Saddle and Ukrainian Saddle breeds. Results of the content of T–helper and T–suppressor cells in foals blood after ribotan administration showed that the use of immunomodulators not only increases the number of T–helper cells, but restores the ratio T–h / T–s, which returned to the optimal rate (1.9). Analyzing the functional status of T–lymphocytes during the application of immunomodulators was found the probable increase of the number of activated T–lymphocytes in Purebred Saddle foals more than 2–fold (P <0.01) and trend to increase of these cells in Ukrainian Saddle foals. In relation to thermostable T–lymphocytes, was note that the trend to the most optimal level of these cells installed in foals after administration of ribotan (values within 3 – 4%). The increasing in number of thermostable T–cells more than 4% indicates an increase power of suppressor T–cells population, indicating the inhibition of T–helper cells, and therefore the production of antibodies. Thus, the use of ribotan in dose of 1 ml / animal for three days leads to an increasing in 1.4 – 4.5% of the number of leukocytes in the blood of experimental group of foals compared with control animals. Under influence of ribotan in the blood of foals increases cell (number of T–lymphocytes in 0.4 – 2.3%) and functional activity (T–active lymphocytes in 2.3 times; P < 0.05) T–immune system. Under influence of cycloferon in the blood of foals increases the functional activity of T–immune system (the number of T–active lymphocytes in 16.7 – 25%; P < 0.05). 

scholarly journals The relationship between the pituitary somatotrophic function and the immune system, its role in the development of neoplasia

2013 ◽  
Vol 59 (1) ◽  
pp. 30-34
Author(s):  
S A Dogadin ◽  
M A Dudina ◽  
A A Savchenko
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Immune System ◽  
Immune Cells ◽  
Functional Activity ◽  
Immune Disorders ◽  
Neoplastic Processes ◽  
The Relationship ◽  
Survivorship Rate

The present review is focused on the relationship between growth hormone (GH) production and the state of the immune system. The influence of growth factors on the population and subpopulation composition of CD-expressing lymphocytes, functional activity of immune cells, and apoptosis is discussed. The detailed description of the role of disturbances in the pituitary somatotrophic function and the concomitant immune disorders is presented with special reference to the development of neoplastic processes. Changes in the immune system of the patients with chronic hypersecretion of growth factors are described. Tight interactions between the immune and endocrine systems appear to greatly contribute to tumour pathogenesis and have direct effect on the survivorship rate among the patients with acromegaly.

scholarly journals Alloantigen–induced specific immunological unresponsiveness

2001 ◽  
Vol 356 (1409) ◽  
pp. 665-680 ◽  
Author(s):  
Kathryn J. Wood ◽  
Nick D. Jones ◽  
Andrew R. Bushell ◽  
Peter J. Morris
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Environmental Conditions ◽  
Functional Activity ◽  
Molecular Mechanisms ◽  
Tolerance Induction ◽  
Therapeutic Agents ◽  
The Future ◽  
The Way

When the immune system encounters alloantigen it can respond in any one of a number of different ways. The choice that is made will take into account factors such as where, when and how the contact with the alloantigen takes place, as well as the environmental conditions that prevail at the time the alloantigen is encountered. Alloantigen administration before transplantation either alone or in combination with therapeutic agents that modulate the functional activity of the responding leucocytes can be a powerful way of inducing specific unresponsiveness to alloantigens in vivo .The molecular mechanisms that influence the way the outcome of the immune response to alloantigen develops, either activation or unresponsiveness to the triggering antigen, hold the key to our ability to manipulate the immune system effectively by exposing it to donor antigen for therapeutic purposes. This review will focus on alloantigen–induced immunological unresponsiveness and how insights into the mechanisms of unresponsiveness have driven the development of novel tolerance–induction strategies that show promise for translation into the clinic in the future.

scholarly journals IMMUNE CELLS AS A POTENTIAL THERAPEUTIC AGENT IN THE TREATMENT OF DEPRESSION

2021 ◽  
Vol 23 (4) ◽  
pp. 699-704
Author(s):  
E. V. Markova ◽  
M. A. Knyazheva
Keyword(s):  
Immune System ◽  
Immune Cells ◽  
Functional Activity ◽  
Depressive Disorders ◽  
Negative Impact ◽  
Critical Role ◽  
Brain Structures ◽  
Biologically Active ◽  
Health Concern

The immune and neuroendocrine systems play a critical role in maintaining a dynamic homeostasis in normal conditions and at mental maladaptation. Psycho- and immunopathology closely interrelated: pathological changes in the functioning of both systems occur simultaneously and are interdependent. Depression, as a mental disorder, is a major public health concern. The estimations are showing rise of the depression’s incidence in the future. However, currently used therapy of depression doesn’t provide a complete cure. It is known that a violation of neuroimmune interaction is an essential link in the pathogenesis of the disease, having a negative impact on its course, making the clinical picture worse, reducing effectiveness of the therapy, therefore, it’s urgent to search for a new treatment approaches. There are a sufficient amount data on the immune cells and their biologically active products leading role in the pathogenesis of depression. The unidirectional effect of most psychoactive substances on the central nervous system and the immune system confirms intersystem mutual regulation and allows considering the immune cells as model objects for influencing the intersystem functional relationship; so, cells immunotherapy can be the method of choice in the treatment of depressive disorders. We first demonstrated the possibility of animal’s behavior directed regulation by the transplantation of immune cells with definite functional characteristics, including those with functional activity modulated extracorporeally by a psychoactive substance. Based on the previous results we investigated the effect of the in vitro caffeine- treated immune cells on the behavior and immune phenotypes in depressive-like singeneic recipients. Transplantation of caffeine-treated splenocytes from depressive-like donors has been shown to induce depressive-like behavior editing in syngeneic recipients, which was manifested in anhedonia decrease, stimulation of exploratory behavior in the Open Field test and motor activity in the Porsolt forced swimming test. Recipient’s behavioral changes were registered on the background of decreased brain pro- inflammatory cytokines (TNFα, IL-1β, IL-6, IFNγ) and IL-10 increased in some pathogenetically significant for depressive-like state brain structures (hippocampus, hypothalamus, frontal cortex, striatum), which indicates a decrease in neuroinflammation. It was also detected recipient’s immune system functional activity modulation. The cytokines-mediated mechanisms of depressive-like behavior editing by the in vitro caffeine- modulated immune cells are discussed. 

Sign in / Sign up

Export Citation Format

Share Document