Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

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Longitudinal cohort study of the impact of specialist cancer services for teenagers and young adults on quality of life: outcomes from the BRIGHTLIGHT study

BMJ Open ◽

10.1136/bmjopen-2020-038471 ◽

2020 ◽

Vol 10 (11) ◽

pp. e038471

Author(s):

Rachel M Taylor ◽

Lorna A Fern ◽

Julie Barber ◽

Javier Alvarez-Galvez ◽

Richard Feltbower ◽

...

Keyword(s):

Quality Of Life ◽

Young Adults ◽

Cohort Study ◽

Young People ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort ◽

Cancer Services ◽

Teenagers And Young Adults ◽

Over Time

ObjectivesIn England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children’s cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTCDesignLongitudinal cohort study.SettingHospitals delivering inpatient cancer care in England.Participants1114 young people aged 13 to 24 years newly diagnosed with cancer.InterventionExposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care.Primary outcomeQuality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis.ResultsGroup mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups.ConclusionsReceipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.

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Comment on “Risk of systemic lupus erythematosus in patients with endometriosis: a nationwide population‑based cohort study”

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-021-06037-3 ◽

2021 ◽

Author(s):

Maria I. Zervou ◽

Michail Matalliotakis ◽

George N. Goulielmos

Keyword(s):

Systemic Lupus Erythematosus ◽

Cohort Study ◽

Lupus Erythematosus ◽

Population Based ◽

Systemic Lupus

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OP0310 Pregnancy outcome in women with systemic lupus erythematosus, a multicenter cohort-study

10.1136/annrheumdis-2017-eular.2831 ◽

2017 ◽

Author(s):

B Blomjous ◽

C Abheiden ◽

S Kroese ◽

J van Laar ◽

R Derksen ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Cohort Study ◽

Pregnancy Outcome ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Multicenter Cohort Study ◽

Multicenter Cohort

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Transitions between levels of dependency among older people receiving social care – a retrospective longitudinal cohort study in a Swedish municipality

BMC Geriatrics ◽

10.1186/s12877-021-02283-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Magnus Zingmark ◽

Fredrik Norström

Keyword(s):

Cohort Study ◽

Older People ◽

Social Care ◽

Early Stage ◽

Cox Proportional Hazards Model ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort ◽

Home Help ◽

Over Time

Abstract Background Knowledge is scarce on how needs for home help and special housing evolve among older people who begin to receive support from municipal social care. The purpose of this study was to describe baseline distributions and transitions over time between levels of dependency among older persons after being granted social care in a Swedish municipality. Methods Based on a longitudinal cohort study in a Swedish municipality, data was collected retrospectively from municipal records. All persons 65 years or older who received their first decision on social care during 2010 (n = 415) were categorized as being in mild, moderate, severe, or total dependency, and were observed until the end of 2013. Baseline distributions and transitions over time were described descriptively and analysed with survival analysis, with the Kaplan-Meier estimator, over the entire follow-up period. To test potential differences in relation to gender, we used the Cox-Proportional hazards model. Results Baseline distributions between mild, moderate, severe, and total dependency were 53, 16, 24, and 7.7%. During the first year, between 40 and 63% remained at their initial level of dependency. Among those with mild and moderate levels of dependency at baseline, a large proportion declined towards increasing levels of dependency over time; around 40% had increased their dependency level 1 year from baseline and at the end of the follow-up, 75% had increased their dependency level or died. Conclusions Older people in Sweden being allocated home help are at high risk for decline towards higher levels of dependency, especially those at mild or moderate dependency levels at baseline. Taken together, it is important that municipalities make use of existing knowledge so that they implement cost-effective preventative interventions for older people at an early stage before a decline toward increasing levels of dependency.

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