scholarly journals Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kosuke Honda ◽  
Satoru Kuriyama ◽  
Kimiyoshi Ichida ◽  
Tomoko Nakano ◽  
Naoki Sugano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid Level ◽  
Human Growth ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

scholarly journals Association Between Polymorphism at IGF-1 rs35767 Gene Locus and Long-term Decline in Renal Function: A Retrospective, Cross-sectional, Longitudinal Cohort Study

2021 ◽  
Author(s):  
Kosuke Honda ◽  
Satoru Kuriyama ◽  
Kimiyoshi Ichida ◽  
Tomoko Nakano ◽  
Naoki Sugano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Glycated Hemoglobin ◽  
Hemoglobin Level ◽  
Cross Sectional ◽  
Glycated Hemoglobin Level

Abstract Background: Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function.Methods: In this retrospective, cross-sectional, longitudinal cohort study, blood samples from 2601 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function.Results: The cohort rs35767 genotypes included 1124 CC carriers (43.2 %), 1180 TC carriers (45.4 %), and 297 TT carriers (11.4 %). Multiple regression analysis revealed no association between IGF-1 genotype and systolic blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, diastolic blood pressure and mean blood pressure were negatively correlated with the TT genotype. In a cross-sectional analysis, factors associated with estimated glomerular filtration rate included higher mean blood pressure and glycated hemoglobin level. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (−18.5 ± 1.04 mL/min/1.73m2) than in CC carriers (−16.4 ± 0.52 mL/min/1.73m2; P < 0.05).Conclusion: The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

scholarly journals Serum Uric Acid Level, Longitudinal Blood Pressure, Renal Function, and Long-Term Mortality in Treated Hypertensive Patients

Hypertension ◽  
2013 ◽  
Vol 62 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Jesse Dawson ◽  
Panniyammakal Jeemon ◽  
Lucy Hetherington ◽  
Caitlin Judd ◽  
Claire Hastie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Hypertensive Patients ◽  
Long Term Mortality

2453-PUB: Changes in Metabolic Syndrome and Diabetes Risk: A Nationwide Longitudinal Cohort Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2453-PUB
Author(s):  
MIN-KYUNG LEE ◽  
HYUK-SANG KWON ◽  
KI-HO SONG ◽  
JAE HYUK LEE
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Diabetes Risk ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

GROUP 6 year outcome data in relation to antipsychotic medication

2016 ◽  
Vol 33 (S1) ◽  
pp. S50-S50
Author(s):  
W. Cahn ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Psychotic Disorders ◽  
Medication Use ◽  
Mood Stabilizer ◽  
Outcome Data ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
The Brain ◽  
Over Time

ObjectiveGenetic risk and outcome of psychoses (GROUP) is a 6 year longitudinal cohort study that focus on gene–environment vulnerability and resilience in patients with psychotic disorders, their unaffected family members and non-related controls. Its main aim is to elucidate etiological and pathogenetic factors that influence the onset and course of psychotic disorders. In this substudy, we will examine medication use over time, its relation with (the change in) metabolic syndrome status and effects on the brain.MethodsA consortium of four university psychiatric centers and their affiliated mental health care institutions, conducted the GROUP study. At baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included. After inclusion, participants, except parents, were evaluated again after three and six years of follow-up. Extensive assessment of genetic factors, environmental factors, medication use, metabolic parameters and outcome were performed. Moreover, brain imaging was performed in a subset of participants, using a 1.5 Tesla MRI scanner.ResultsAt baseline 65% of patients used atypical antipsychotics, 16% used conventional antipsychotics and 19% used clozapine. Siblings and controls used no antipsychotics. Forty-three percent of patients, 21.3% of siblings and 9.1% of controls used antidepressants; 43.9% of patients, 2.1% of siblings and none of the controls used a mood stabilizer. We are currently analyzing the medication data over time in relation to (change in) metabolic syndrome status and the effects on the brain.ConclusionGROUP is a longitudinal cohort study in patients with psychotic disorders, their healthy siblings and controls without psychosis. This naturalistic substudy examines medication use, its association with (change of) metabolic status and effects on the brain in subjects with (high risk of) psychosis.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Gestational diabetes and the long-term risk of cataract surgery: A longitudinal cohort study

2017 ◽  
Vol 31 (11) ◽  
pp. 1565-1570 ◽  
Author(s):  
Nathalie Auger ◽  
Tina Tang ◽  
Jessica Healy-Profitós ◽  
Gilles Paradis
Keyword(s):  
Cohort Study ◽  
Gestational Diabetes ◽  
Cataract Surgery ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

scholarly journals Long-term distress in older patients with cancer: a longitudinal cohort study

BJGP Open ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. bjgpopen19X101658 ◽  
Author(s):  
Stephanie Dauphin ◽  
Leontien Jansen ◽  
Tine De Burghgraeve ◽  
Laura Deckx ◽  
Frank Buntinx ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Diagnosis ◽  
Older Patients ◽  
Contact Point ◽  
Longitudinal Cohort Study ◽  
Aged Patients ◽  
Major Life ◽  
Longitudinal Cohort ◽  
Patients With Cancer

BackgroundReceiving a cancer diagnosis can be a major life event which causes distress even years after primary treatment.AimTo examine the prevalence of distress in older patients with cancer (OPCs) up until 5 years post-diagnosis, and identify predictors present at time of diagnosis. Results are compared with reference groups of middle-aged patients with cancer (MPCs) and older patients without a cancer diagnosis (OPs).Design & settingOPCs, MPCs, and OPs participated in a longitudinal cohort study in Belgium and the Netherlands by filling in questionnaires at designated time points from 2010–2019.MethodData from 541 patients were analysed using multivariable logistic regression analyses.ResultsAt baseline, 40% of OPCs, 37% of MPCs, and 17% of OPs reported distress. After 5 years, 35% of OPCs, 23% of MPCs, and 25% of OPs reported distress. No significant predictors for long-term distress in OPCs and OPs were found. For MPCs, it was found that baseline distress (odds ratio [OR] 2.94; 95% confidence intervals [CI] = 1.40 to 6.19) and baseline fatigue (OR 4.71; 95% CI = 1.81 to 12.31) predicted long-term distress.ConclusionDistress is an important problem for people with cancer, with peaks at different moments after diagnosis. Feelings of distress are present shortly after diagnosis but they decrease quickly for the majority of patients. In the long term, however, OPCs in particular appear to be most at risk for distress. This warrants extra attention from primary healthcare professionals, such as GPs who are often patients’ first medical contact point. More research into risk factors occurring later in an illness trajectory might shed more light on predictors for development of long-term distress.

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