scholarly journals Relationship between the use of polymyxin B-immobilized fiber for hemofiltration and some laboratory parameters (endocannabinoids, high mobility group box-1 protein and oxidative stress) in severe pneumonia patients

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P456
Author(s):  
K Mashiko ◽  
Y Sakamoto ◽  
T Obata ◽  
H Matsumoto ◽  
Y Hara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Mobility ◽  
Severe Pneumonia ◽  
Polymyxin B ◽  
High Mobility Group ◽  
Laboratory Parameters ◽  
And Oxidative Stress

The Effect of Ethyl Pyruvate on High Mobility Group Box I and Oxidative Stress in Induced Rheumatoid Arthritis in Rats

2019 ◽  
Vol 87 (June) ◽  
pp. 2547-2554
Author(s):  
HADEER S. SALAH, M.Sc. OMNIA S. EL-DEEB, M.D. ◽  
SAAD EL-DEEN A. ABO EL-NOEMAN, M.D NAGAH K. GAAFAR, M.D.
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Ethyl Pyruvate ◽  
High Mobility ◽  
High Mobility Group ◽  
And Oxidative Stress

MiR-582-5p attenuates neonatal hypoxic-ischemic encephalopathy by targeting high mobility group box 1 (HMGB1) through inhibiting neuroinflammation and oxidative stress

2021 ◽  
Vol 18 ◽  
Author(s):  
Guang Yang ◽  
Zhimin Xue ◽  
Yuan Zhao
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Pc12 Cells ◽  
Pc12 Cell ◽  
Cell Injury ◽  
High Mobility ◽  
High Mobility Group ◽  
Hypoxic Ischemic Encephalopathy ◽  
And Oxidative Stress ◽  
Ischemic Encephalopathy

Background: MiR-582-5p has been demonstrated to protect against ischemic stroke. However, its implication in the progression of neonatal hypoxic-ischemic encephalopathy (HIE) has not been explored. Methods: In this study, we used an in vitro model of oxygen-glucose deprivation (OGD) to investigate the protective effect of miR-582-5p on PC12 cells. OGD-induced inhibition of cell viability and promotion of cell death was assessed by CCK-8 assay and flow cytometry. Real-time PCR and enzyme-linked immunosorbent assay (ELISA) were utilized to examine the levels of inflammatory cytokines. The effects of miR-582-5p on OGD-induced oxidative injury were assessed by the determination of oxidative stress indicators. Furthermore, dual-luciferase reporter assay and gain-offunction assay were used to determine the mechanism of miR-582-5p in OGD-induced cell injury. Results : The expression of miR-582-5p was reduced upon OGD treatment in PC12 cells. Overexpression of miR-582-5p inhibited OGD-induced PC12 cell injury by regulating cell viability, apoptosis, inflammatory responses, and oxidative stress. MiR-582-5p targeted and negatively regulated high mobility group box 1 (HMGB1). MiR-582-5p presented protective effects on OGD-induced PC12 cell injury by targeting HMGB1. Conclusion: Our results indicated that miR-582-5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1.

scholarly journals High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

2011 ◽  
Vol 15 (8) ◽  
pp. 2185-2195 ◽  
Author(s):  
Daolin Tang ◽  
Rui Kang ◽  
Kristen M. Livesey ◽  
Herbert J. Zeh ◽  
Michael T. Lotze
Keyword(s):  
Oxidative Stress ◽  
High Mobility ◽  
High Mobility Group

scholarly journals High-Mobility Group Box 1, Oxidative Stress, and Disease

2011 ◽  
Vol 14 (7) ◽  
pp. 1315-1335 ◽  
Author(s):  
Daolin Tang ◽  
Rui Kang ◽  
Herbert J. Zeh ◽  
Michael T. Lotze
Keyword(s):  
Oxidative Stress ◽  
High Mobility ◽  
High Mobility Group

scholarly journals The Effect of Modified Porcine Surfactant Alone or in Combination with Polymyxin B on Lung Homeostasis in LPS-Challenged and Mechanically Ventilated Adult Rats

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4356 ◽  
Author(s):  
Maros Kolomaznik ◽  
Jana Kopincova ◽  
Zuzana Nova ◽  
Juliana Topercerova ◽  
Ivan Zila ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Lavage Fluid ◽  
Polymyxin B ◽  
Exogenous Surfactant ◽  
Lung Edema ◽  
Adult Rats ◽  
Mechanically Ventilated ◽  
Proinflammatory Mediators ◽  
And Oxidative Stress

The study aimed to prove the hypothesis that exogenous surfactant and an antibiotic polymyxin B (PxB) can more effectively reduce lipopolysaccharide (LPS)-induced acute lung injury (ALI) than surfactant treatment alone, and to evaluate the effect of this treatment on the gene expression of surfactant proteins (SPs). Anesthetized rats were intratracheally instilled with different doses of LPS to induce ALI. Animals with LPS 500 μg/kg have been treated with exogenous surfactant (poractant alfa, Curosurf®, 50 mg PL/kg b.w.) or surfactant with PxB 1% w.w. (PSUR + PxB) and mechanically ventilated for 5 hrs. LPS at 500 μg/kg increased lung edema, oxidative stress, and the levels of proinflammatory mediators in lung tissue and bronchoalveolar lavage fluid (BALF). PSUR reduced lung edema and oxidative stress in the lungs and IL-6 in BALF. This effect was further potentiated by PxB added to PSUR. Exogenous surfactant enhanced the gene expression of SP-A, SP-B, and SP-C, however, gene expression for all SPs was reduced after treatment with PSUR + PxB. In mechanically ventilated rats with LPS-induced ALI, the positive effect of exogenous surfactant on inflammation and oxidative stress was potentiated with PxB. Due to the tendency for reduced SPs gene expression after surfactant/PxB treatment topical use of PxB should be considered with caution.

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