scholarly journals Low preoperative total lymphocyte count as a predictor of poor outcome in adult cardiac surgery

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
V Lomivorotov ◽  
S Efremov ◽  
V Boboshko
2011 ◽  
Vol 25 (6) ◽  
pp. 975-980 ◽  
Author(s):  
Vladimir V. Lomivorotov ◽  
Sergey M. Efremov ◽  
Vladimir A. Boboshko ◽  
Ilya N. Leyderman ◽  
Vladimir N. Lomivorotov ◽  
...  

2015 ◽  
Vol 17 (2) ◽  
pp. 41
Author(s):  
V. V. Lomivorotov ◽  
S. M. Yefremov ◽  
V. A. Boboshko ◽  
V. A. Shmyrev

The aim of this study retrospective cohort was to investigate the prognostic value of preoperative total lymphocyte count in peripheral blood as a predictor of postoperative complications and mortality in cardiac surgery. All adults undergoing cardiopulmonary bypass in 2009. The cohort size was 1 368 patients. Patient characteristics, hospital mortality, postoperative complications, ventilation period, intensive care unit and hospital stay were analysed. Preoperative total lymphocyte count <1 611 cells/L was assotiated with significantly higher mortality by univariate (p<0,0001) and multivariate (p<0,022) analisys. Low preoperative total lymphocyte count was associated with more frequent inotropic support (p<0,001); postoperative heart arrhythmia (p<0,001); hemodialysis-dependent acute renal failure (p<0,001); and a prolonged ventilation period (p=0,001), intensive care unit stay (p<0,001), and hospital stay (p=0,007). Low preoperative total lymphocyte count in peripheral blood is a useful prognostic criterion for evaluation of a complicated postoperative period in cardiosurgical patients.


1996 ◽  
Vol 7 (6) ◽  
pp. 422-428 ◽  
Author(s):  
E J Beck ◽  
E J Kupek ◽  
M M Gompels ◽  
A J Pinching

The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals. Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples. Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991. Costing data were obtained through a survey of the departments of haematology and immunology 1989 90 prices . The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high R 0.76 . When analysed by stage of HIV infection, the correlation increased from R 0.64 for asymptomatic patients, to R 0.72 for patients with symptomatic non-AIDS HIV infection and R 0.73 for AIDS patients. Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker: R 0.41 all paired counts; R 0.32 for asymptomatic patients; R 0.25 for symptomatic non-AIDS patients; R 0.32 for AIDS patients. Average cost was 8 per full blood count compared with 38 per T-cell subset analysis. The high correlation between total and CD4 lymphocyte counts, especially for patients with symptomatic HIV disease, demonstrates the suitability of the use of total lymphocyte count in the absence of CD4 counts. Given the considerably lower prices of total lymphocyte counts compared with T-cell subset analysis, this is particularly relevant for developing countries.


2010 ◽  
Vol 29 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Brendan J. O'Daly ◽  
James C. Walsh ◽  
John F. Quinlan ◽  
Gavin A. Falk ◽  
Robert Stapleton ◽  
...  

2017 ◽  
Vol 5 (1) ◽  
pp. 56
Author(s):  
Rizka Bekti Nurcahyani ◽  
Imelda T Pardede ◽  
Huriatul Masdar

Adequate nutrition is one of important factors in immunodeficiency repairment. Soybean and tempeh contains proteins,zinc, ferrum, vitamins and isoflavon. Fermentation in tempeh makes it having better nutrients digestion and absorptionthan soybean. The objective of this study was to compare the effects of soy and tempeh emulsions on total lymphocytecount in rats treated with prednisone. The test was done on 24 male white rats divided into four groups. Group A wasgiven distilled water and group B, C and D had prednisone 2.5 mg/day for 6 days. After that, group A and B werecontinued having distilled water while groups C or D was fed with soy or tempeh emulsion 0.71 mL/day for 10 days,respectively. The results shown that soy and tempeh emulsion could increase total lymphocyte count significantly (p <0,05) but there was no significant difference of total lymphocyte count between soy and tempeh emulsion groups (p >0,05).


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