Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

Abstract Background The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson’s disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). Methods Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data. Results Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group. Conclusion Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research.

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Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2020.00213 ◽

2020 ◽

Vol 12 ◽

Cited By ~ 1

Author(s):

Chengxian Yang ◽

Jianbo Chang ◽

Xiaohang Liang ◽

Xinjie Bao ◽

Renzhi Wang

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Eye Movement ◽

Gray Matter ◽

Meta Analysis ◽

Behavior Disorder ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Voxel Based Morphometry ◽

Sleep Behavior

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Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

Parkinson s Disease ◽

10.1155/2021/8851027 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Xu Jiang ◽

Zhuang Wu ◽

Min Zhong ◽

Bo Shen ◽

Jun Zhu ◽

...

Keyword(s):

Executive Function ◽

Functional Connectivity ◽

Eye Movement ◽

Gray Matter ◽

Rem Sleep ◽

Gray Matter Volume ◽

Behavior Disorder ◽

Sleep Behavior ◽

Matter Volume ◽

The Right

Objective. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common symptom in Parkinson’s disease (PD), and patients with PD-RBD tend to have an increased risk of cognitive decline and have the tendency to be akinetic/rigidity predominant. At the same time, the mechanisms of RBD in patients with PD remain unclear. Therefore, this study aimed to detect the structural and functional differences in patients with PD-RBD and PD without RBD (PD-nRBD). Methods. Twenty-four polysomnography-confirmed patients with PD-RBD, 26 patients with PD-nRBD, and 26 healthy controls were enrolled. Structural and functional patterns were analyzed based on voxel-based morphometry and seed-based functional connectivity (FC). Correlations between altered gray matter volume (GMV)/FC values and cognitive scores and motor impairment scores in PD subgroups were assessed. Results. Compared with patients with PD-nRBD, patients with PD-RBD showed relatively high GMV in the cerebellar vermis IV/V and low GMV in the right superior occipital gyrus (SOG). For the FC, patients with PD-RBD displayed lower FC between the right SOG and the posterior regions (left fusiform gyrus, left calcarine sulcus, and left superior parietal gyrus) compared with the patients with PD-nRBD. The GMV values in the right SOG were negatively correlated with the Unified PD Rating Scale-III scores in patients with PD-RBD but positively correlated with delayed memory scores. The GMV values in the cerebellar vermis IV/V were positively correlated with the tonic chin EMG density scores. There were positive correlations between the FC values in the right SOG-left superior parietal gyrus and MoCA and visuospatial skills/executive function scores and in the right SOG-left calcarine sulcus and delayed memory scores. Conclusion. Higher GMV in the cerebellum may be linked with the abnormal motor behaviors during REM sleep in patients with PD-RBD, and lower GMV and FC in the posterior regions may indicate that PD-RBD correspond to more serious neurodegeneration, especially the visuospatial–executive function impairment and delayed memory impairment. These findings provided new insights to learn more about the complicated characteristics in patients with PD-RBD.

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Abnormal Gray Matter Shape, Thickness, and Volume in the Motor Cortico-Subcortical Loop in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: Association with Clinical and Motor Features

Cerebral Cortex ◽

10.1093/cercor/bhx137 ◽

2017 ◽

Vol 28 (2) ◽

pp. 658-671 ◽

Cited By ~ 17

Author(s):

Shady Rahayel ◽

Ronald B Postuma ◽

Jacques Montplaisir ◽

Christophe Bedetti ◽

Simona Brambati ◽

...

Keyword(s):

Eye Movement ◽

Gray Matter ◽

Behavior Disorder ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Sleep Behavior

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White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: A diffusion-tensor imaging and voxel-based morphometry study

Annals of Neurology ◽

10.1002/ana.22245 ◽

2010 ◽

Vol 69 (2) ◽

pp. 400-407 ◽

Cited By ~ 133

Author(s):

Christoph Scherfler ◽

Birgit Frauscher ◽

Michael Schocke ◽

Alex Iranzo ◽

Viola Gschliesser ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Eye Movement ◽

Gray Matter ◽

Diffusion Tensor ◽

Behavior Disorder ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Voxel Based Morphometry ◽

Sleep Behavior

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Predictors of Conversion to α-Synucleinopathy Diseases in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Journal of Parkinson s Disease ◽

10.3233/jpd-202243 ◽

2020 ◽

Vol 10 (4) ◽

pp. 1443-1455

Author(s):

Guanyu Ye ◽

Yuanyuan Li ◽

Liche Zhou ◽

Yichi Zhang ◽

Lin Zhu ◽

...

Keyword(s):

Eye Movement ◽

Gray Matter ◽

Verbal Learning ◽

Behavior Disorder ◽

Rapid Eye Movement ◽

Rapid Eye Movement Sleep ◽

Sleep Behavior ◽

Predictive Values ◽

Clinical Variables ◽

Gray Matter Atrophy

Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) often precedes the development of α-synucleinopathy diseases. Objective: We aimed to assess the predictive value of clinical variables and biomarkers for the early development of α-synucleinopathy diseases in subjects with iRBD. Methods: 56 patients with RBD Screening Questionnaire (RBDSQ) scores ≥5 at baseline and subsequent visit were enrolled as probable iRBD from the Parkinson’s Progression Markers Initiative (PPMI) database. Baseline clinical data and biomarkers were analyzed. The endpoint was defined as disease progression to α-synucleinopathy diseases. Cox proportional hazard and Kaplan-Meier analyses were used to evaluate the predictive values of the indicators. Results: During a mean follow-up duration of 5.1 years, 15 of 56 patients (26.8%) developed α-synucleinopathy diseases. Baseline clinical variables, including University of Pennsylvania Smell Identification Test (UPSIT, HR = 26.18, p = 0.004), 15-item Geriatric Depression Scale (GDS, HR = 14.26, p = 0.001), Montreal Cognitive Assessment (MoCA, HR = 3.56, p = 0.025), and Hopkins Verbal Learning Test Total recall (HVLT-TR, HR = 3.70, p = 0.014); genotype status of TMEM175 (HR = 3.74, p = 0.017), SCN3A (HR = 5.81, p = 0.022) and NUCKS1 (HR = 0.342, p = 0.049); ratio of phosphorylated tau to total tau (p-tau/t-tau, HR = 8.36, p = 0.001) in cerebrospinal fluid; and gray matter atrophy in inferior frontal gyrus (IFG, HR = 15.49, p = 0.001) were associated with phenoconversion to α-synucleinopathy diseases. A model combined the three independent variables (UPSIT, TMEM175 and gray matter atrophy in IFG) exhibited significantly improved predictive performance. Conclusion: For patients with iRBD, progression to α-synucleinopathy diseases can be predicted with good accuracy using a model combining clinical variables and biomarkers, which could form a basis for future disease prevention.

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