The effect of vitamin A and zinc supplementation on the bacteriological response of persons with pulmonary tuberculosis in the Western Cape

2012 ◽  
Author(s):  
Marianne Emilie Visser
2010 ◽  
Vol 93 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Marianne E Visser ◽  
Harleen MS Grewal ◽  
Elizabeth C Swart ◽  
Muhammad A Dhansay ◽  
Gerhard Walzl ◽  
...  

Author(s):  
Yeswanth Prasanna Kumar B ◽  
Praveen D ◽  
Vijey Aanandhi M

Aim and Objectives: The aim of the study was to study the serum zinc (Zn) levels, safety, and efficacy of Zn supplementation in pulmonary tuberculosis (PTB) patients.Methods: A randomized single-blinded study of two groups: Group A received conventional TB therapy while Group B received conventional TB therapy along with 15 mg of Zn tablet. 40 patients were assigned in each group by randomized permuted blocks.Results: After 8 weeks of treatment in Group A 27 patients and Group B 36 patients were found to be sputum negative with p=0.0421 and 0.0629. After 24 weeks of treatment in Group A 37 patients and Group B 40 patients were found to be sputum negative with p=0.00976 and 0.00971. By this, the given treatment was effective in the patients with PTB.Conclusion: Zn supplementation improves the effect of TB medication treatment and results in earlier sputum smear conversion.


2013 ◽  
Vol 83 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Endy P. Prawirohartono ◽  
Lennarth Nyström ◽  
Detty S. Nurdiati ◽  
Mohammad Hakimi ◽  
Torbjörn Lind

Background: Prenatal supplementation with micronutrients may increase birth weight and thus improve infant health and survival in settings where infants and children are at risk of micronutrient deficiencies. Objective: To assess whether vitamin A and/or zinc supplementation given during pregnancy can improve birth weight, birth length, neonatal morbidity, or infant mortality. Methods: A double-blind, randomized controlled trial supplementing women (n = 2173) in Central Java, Indonesia throughout pregnancy with vitamin A, zinc, combined vitamin A+zinc, or placebo. Results: Out of 2173 supplemented pregnant women, 1956 neonates could be evaluated. Overall, zinc supplementation improved birth length compared to placebo or combined vitamin A+zinc (48.8 vs. 48.5 cm, p = 0.04); vitamin A supplementation improved birth length compared to placebo or combined vitamin A+zinc (48.7 vs. 48.2 cm, p = 0.04). These effects remained after adjusting for maternal height, pre-pregnancy weight, and parity. There was no effect of supplementation on birth weight, the proportion of low birth weight, neonatal morbidity, or mortality. Conclusions: Prenatal zinc or vitamin A supplementation demonstrates a small but significant effect on birth length, but supplementation with zinc, vitamin A or a combination of zinc and vitamin A, have no effect on birth weight, neonatal morbidity, or mortality.


1999 ◽  
Vol 18 (3) ◽  
pp. 213-222 ◽  
Author(s):  
J. Cecil Smith ◽  
Dhiren Makdani ◽  
Amin Hegar ◽  
David Rao ◽  
Larry W. Douglass

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