Effect of vitamin A supplementation in category-I Pulmonary Tuberculosis patients in a Medical College in India: a rapid assessment analysis

Aim : To Determine the seroprevalence of Human immunodeficiency virus infection among Pulmonary Tuberculosis patients in a tertiary care teaching institution, in Ernakulam district of Kerala state in India. Methods : Study was conducted in Respiratory medicine department and integrated counselling and testing centre (ICTC) of Government Medical College, Ernakulam With approval of IEC after getting written informed consent , a cross sectional study was conducted among 384 pulmonary TB patients who were registered under the National TB elimination Programme (RNTCP). Result :The prevalence of HIV among study population was 1.3 %. There was no gender difference while the highest age group less than 30 followed by 30-60. The major respiratory pathology among study subjects was consolidation (42.7%) followed by fibrosis(25.3%).Consolidation was a predominant presenting pathology seen in female pulmonary TB patients.The sensitivity of sputum smear against CBNAAT was 60.4% and specificity was 83%. Conclusion : The prevalence is low compared with the national average of 3 to 3.4 % HIV co infection among Tuberculosis patients during the study period.

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Vitamin A Supplementation in Pulmonary Tuberculosis Patients on Acceleration of Sputum Conversion in Medan City

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.688 ◽

2019 ◽

Vol 7 (20) ◽

pp. 3505-3508

Author(s):

Dina Keumala Sari ◽

Alexander Parlindungan Marpaung ◽

Parluhutan Siagian ◽

Nurfida Khairina Arrasyid

Keyword(s):

Treatment Group ◽

Vitamin A ◽

University Students ◽

Control Group ◽

Vitamin A Supplementation ◽

Intensive Phase ◽

Tuberculosis Patients ◽

Pulmonary Tb ◽

Sputum Conversion ◽

Conversion Time

BACKGROUND: Indonesia is in the second rank for the most TB (Tuberculosis) cases in the world after India. It is estimated that there are 1 million cases per year in Indonesia. AIM: To find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at an intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict METHODS: This research was Quasi Experiment method. With two groups. The samples were 30 newly diagnosed pulmonary TB patients consisting of of15 patients in the treatment group and 15 patients in the control group. The statistical data were analysed with t independent test, significance 95% (p < 0.05) RESULTS: The treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputum conversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at the intensive phase (p ≤ 0.001). CONCLUSION: We concluded that Vitamin A in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at the intensive phase in the Medan Kota.

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A prospective, open label, randomized study of efficacy of vitamin A as an add on therapy in the clinical outcome of tuberculosis patients

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20172083 ◽

2017 ◽

Vol 6 (6) ◽

pp. 1333

Author(s):

Sujatha G. ◽

Suguna Bai A. ◽

Preetha N.

Keyword(s):

Drug Therapy ◽

Vitamin A ◽

Pulmonary Tuberculosis ◽

Randomized Study ◽

Phase Iii ◽

Controlled Study ◽

Control Group ◽

Standard Drug ◽

Total Period ◽

Tuberculosis Patients

Background: Tuberculosis is the most prevalent infectious disease in the world. India accounts for nearly one fifth of global incidence of tuberculosis. If untreated the disease may be fatal within five years in 50-65 percent of cases. Many decades of research have shown that severe oxidative stress plays a significant role in tuberculosis patients. Moreover, the malnutrition which is commonly present in patient with tuberculosis can add to the impaired anti oxidant capacity. The present study was to investigate the effect of supplementation of vitamin A with standard treatment on the health status of newly diagnosed sputum positive pulmonary tuberculosis patients.Methods: Phase III, prospective, open, two arm parallel group, outpatient, randomized, active controlled study. Centre of the study was Tuberculosis clinic, Department of Internal medicine, Stanley Medical College Chennai.Duration of the study was for active drug therapy - 2 months, for follow up period - 4 months and for total period - 6 months.Results: In our study it was evident that there was a statistically significant improvement in the Karnofsky’s score, body mass index, mid upper arm circumference in the in the vitamin A supplementation group when compared to the control group at the end of 2 months and 6 months. And also, a statistically significant decrease in C.R.P. levels and E.S.R levels were also observed.Conclusions: This study shows that vitamin A as an add on therapy with regular anti-tuberculosis treatment improves the quality of life and decreases the disease activity in pulmonary tuberculosis patients to a greater extent than with routine standard drug therapy alone.

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Evaluation of Peripheral Blood Parameters of Pulmonary Tuberculosis Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: Comparative Study

Journal of Blood Medicine ◽

10.2147/jbm.s237317 ◽

2020 ◽

Vol Volume 11 ◽

pp. 115-121

Author(s):

Daniel Kahase ◽

Absra Solomon ◽

Mihret Alemayehu

Keyword(s):

Pulmonary Tuberculosis ◽

Comparative Study ◽

Peripheral Blood ◽

Addis Ababa ◽

Blood Parameters ◽

Tuberculosis Patients ◽

Medical College

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A study to assess the clinico-radiological and spirometric proৎile of post tuberculosis patients in a tertiary care centre

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4304 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 1350-1356

Author(s):

Kavya S ◽

Priya Joy ◽

Gangadharan V

Keyword(s):

Pulmonary Tuberculosis ◽

Tertiary Care ◽

Lung Parenchyma ◽

Airway Disease ◽

Tertiary Care Centre ◽

Tuberculosis Patients ◽

Medical College ◽

Small Airway Disease ◽

Significant Difference ◽

History Of

Tuberculosis is an infectious disease which has affected millions of people around the world. Ten million new TB cases were identified globally in 2018, with an estimated 1.2 million deaths. Lung function impairment often occurs due to the destruction of the lung parenchyma. This causes ventilatory abnormalities, often of obstructive type. Radiological lesions are also a common consequence of pulmonary tuberculosis. This study aims to analyse the various clinical features and assess the spirometric and radiological findings in post TB patients. This is a prospective observational study. All patients visiting the Chest Medicine OPD of Saveetha Medical College and Hospital who had a history of treated pulmonary tuberculosis and were above 18 years of age were included in this study. Patients who had no signs of active Tuberculosis underwent spirometry, and a chest x-ray was taken. Clinical presentation, spirometric parameters and radiological lesion were analysed. Among the 76 patients included in this study, 73.7% were male with most patients aged between 51 to 60 years. 64.5% of the study population were smokers. Dyspnoea (94.73%) was found to be the most common presenting complaint. Obstructive pattern (49%) was found to be the most common type of spirometric pattern with 68.42% having small airway disease. Based on the Wilcox classification, Degree II (47.37%) was the most common extent of the radiological lesion. It was found that there is a statistically significant difference between smokers and non-smokers in post-bronchodilator FEV1 (p=0.037) and FEF25-75 values (p=0.010). This study reveals the presence of post tuberculosis lung impairment in the population with varying presentations and severity. Hence, further studies and interventions are required to improve the quality of life of post tuberculosis patients.

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