scholarly journals Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows

BMC Genomics ◽  
2017 ◽  
Vol 18 (1) ◽  
Author(s):  
S. Wilkinson ◽  
S.C. Bishop ◽  
A.R. Allen ◽  
S.H. McBride ◽  
R.A. Skuce ◽  
...  
1961 ◽  
Vol 57 (3) ◽  
pp. 289-294 ◽  
Author(s):  
S. R. Searle

Part of the variation among butterfat yields in dairy cows arises from genetic differences among the animals. The proportion which this bears to the total variance is known as heritability. In the ‘narrow’ sense it is defined (Lush, 1940), as the proportion of the total variance that is due to additive gene effects; the ‘broad’ sense definition includes genetic variation arising from non-additive gene effects as well as that due to additive effects. Since related animals have a proportion of their genes in common the covariance among their production records can be used for estimating genetic variation and hence heritability. This paper discusses three groups of related animals most frequently used for this purpose, twins, daughter-dam pairs and paternal half-sibs, and presents the results of analysing production records of artificially bred heifers in New Zealand, including evidence of the magnitude of the sampling errors of the heritability estimates.


Agronomie ◽  
1997 ◽  
Vol 17 (2) ◽  
pp. 119-125 ◽  
Author(s):  
J. C. Émile ◽  
M. Mauries ◽  
G. Allard ◽  
P. Guy

2020 ◽  
Vol 11 ◽  
Author(s):  
Jinmei Ding ◽  
Ting Jiang ◽  
Hao Zhou ◽  
Lingyu Yang ◽  
Chuan He ◽  
...  

2019 ◽  
Vol 21 (1) ◽  
pp. 63-70
Author(s):  
Tom Parks ◽  
Katherine Elliott ◽  
Theresa Lamagni ◽  
Kathryn Auckland ◽  
Alexander J. Mentzer ◽  
...  

2007 ◽  
Vol 101 (4) ◽  
pp. 1083-1089 ◽  
Author(s):  
Gregory J. Sandland ◽  
Alice V. Foster ◽  
Monika Zavodna ◽  
Dennis J. Minchella

2017 ◽  
Author(s):  
David Enard ◽  
Dmitri A Petrov

AbstractNeanderthals and modern humans came in contact with each other and interbred at least twice in the past 100,000 years. Such contact and interbreeding likely led both to the transmission of viruses novel to either species and to the exchange of adaptive alleles that provided resistance against the same viruses. Here, we show that viruses were responsible for dozens of adaptive introgressions between Neanderthals and modern humans. We identify RNA viruses—specifically lentiviruses and orthomyxoviruses—as likely drivers of introgressions from Neanderthals to Europeans. Our results imply that many introgressions between Neanderthals and modern humans were adaptive, and that host genetic variation can be used to understand ancient viral epidemics, potentially providing important insights regarding current and future epidemics.One Sentence SummaryOnce out of Africa, modern humans inherited from Neanderthals dozens of genes already adapted against viruses present in their new environment.


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