scholarly journals Soluble factors from biofilm of Candida albicans and Staphylococcus aureus promote cell death and inflammatory response

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Kassia de Carvalho Dias ◽  
Paula Aboud Barbugli ◽  
Fernanda de Patto ◽  
Virginia Barreto Lordello ◽  
Letícia de Aquino Penteado ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Death ◽  
Candida Albicans ◽  
Inflammatory Response ◽  
Soluble Factors ◽  
And Staphylococcus Aureus ◽  
Promote Cell Death

scholarly journals Oral Administration of the Broad-Spectrum Antibiofilm Compound Toremifene Inhibits Candida albicans and Staphylococcus aureus Biofilm FormationIn Vivo

2014 ◽  
Vol 58 (12) ◽  
pp. 7606-7610 ◽  
Author(s):  
Kaat De Cremer ◽  
Nicolas Delattin ◽  
Katrijn De Brucker ◽  
Annelies Peeters ◽  
Soña Kucharíková ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Broad Spectrum ◽  
Staphylococcus Epidermidis ◽  
Biofilm Formation ◽  
Candida Krusei ◽  
Content Type ◽  
And Staphylococcus Aureus

ABSTRACTWe here report on thein vitroactivity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, includingCandida albicans,Candida glabrata,Candida dubliniensis,Candida krusei,Pseudomonas aeruginosa,Staphylococcus aureus, andStaphylococcus epidermidis. We validated thein vivoefficacy of orally administered toremifene againstC. albicans and S. aureusbiofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.

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