scholarly journals High sensitivity C reactive protein, fibrinogen levels and the onset of major depressive disorder in post-acute coronary syndrome

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Marianne Lafitte ◽  
Sandrine Tastet ◽  
Paul Perez ◽  
Marie-Aimée Serisé ◽  
Anne-Sophie Grandoulier ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Reactive Protein ◽  
Coronary Syndrome

scholarly journals Association of high-sensitivity C-reactive protein with de novo major depression

2010 ◽  
Vol 197 (5) ◽  
pp. 372-377 ◽  
Author(s):  
Julie A. Pasco ◽  
Geoffrey C. Nicholson ◽  
Lana J. Williams ◽  
Felice N. Jacka ◽  
Margaret J. Henry ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
De Novo ◽  
High Sensitivity ◽  
Prior History ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Standard Deviation Increase ◽  
Reactive Protein ◽  
Increased Risk

BackgroundAlthough there is cross-sectional evidence that changes in the immune system contribute to the pathophysiology of depression, longitudinal data capable of elucidating cause and effect relationships are lacking.AimsWe aimed to determine whether subclinical systemic inflammation, as measured by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with an increased risk of de novo major depressive disorder.MethodMajor depressive disorder was diagnosed using a clinical interview (SCID–I/NP). This is a retrospective cohort study; from a population-based sample of 1494 randomly selected women recruited at baseline during the period 1994–7, 822 were followed for a decade and provided measures of both exposure and outcome. Of these women, 644 (aged 20–84 years) had no prior history of depression at baseline and were eligible for analysis.ResultsDuring 5827 person-years of follow-up, 48 cases of de novo major depressive disorder were identified. The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04–1.99), after adjusting for weight, smoking and use of non-steroidal anti-inflammatory drugs. Further adjustment for other lifestyle factors, medications and comorbidity failed to explain the observed increased risk for depression.ConclusionsSerum hsCRP is an independent risk marker for de novo major depressive disorder in women. This supports an aetiological role for inflammatory activity in the pathophysiology of depression.

scholarly journals C-reactive protein and clinical subtypes of major depressive disorder at Zagazig University Hospitals

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Amany Elshabrawy Mohamed ◽  
Rafik Reda Abd El-Latif ◽  
Amira Mohamed Youssef ◽  
Abdallah Saad Ibrahim
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
C Reactive Protein ◽  
University Hospitals ◽  
Major Depressive ◽  
Reactive Protein

C-reactive protein: A differential biomarker for major depressive disorder and bipolar II disorder

2016 ◽  
Vol 18 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Hui Hua Chang ◽  
Tzu-Yun Wang ◽  
I Hui Lee ◽  
Sheng-Yu Lee ◽  
Kao Chin Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Protein A ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Bipolar Ii Disorder ◽  
Reactive Protein ◽  
Bipolar Ii

Higher level of high sensitivity C-reactive protein is associated with more fibrocalcific plaque and longer lesion in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Katamine ◽  
Y Minami ◽  
K Asakura ◽  
A Kato ◽  
A Katsura ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Morphological Characteristics ◽  
High Sensitivity ◽  
Current Smoker ◽  
Lesion Length ◽  
Culprit Lesion ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Coronary Syndrome

Abstract Background The association between the level of high sensitivity C-reactive protein (hsCRP) and coronary plaque characteristics in patients with acute coronary syndrome (ACS) remains to be elucidated. Purpose To clarify the morphological characteristics of culprit lesion in patients with ACS according to the hsCRP levels using optical coherence tomography (OCT). Methods A total of 215 consecutive patients with ACS, who underwent OCT imaging of culprit lesions were included. The patients were classified into either the higher hsCRP group (hsCRP ≥0.14 mg/dL, n=108) or the lower hsCRP group (hsCRP <0.14 mg/dL, n=107) according to the median preprocedural hsCRP level. The morphological characteristics of culprit lesion assessed by OCT were compared between the two groups. Results The higher hsCRP group had higher prevalence of insulin therapy (14 vs. 6%, p=0.037) and current smoker than the lower hsCRP group (37 vs. 18%, p=0.002). The prevalence of long lesion (≥25 mm, 67 vs. 53%, p=0.041) and fibrocalcific plaque (53 vs. 33%, p=0.003) was significantly higher in the higher hsCRP group than in the lower hsCRP group (Figure). On the other hand, the prevalence of plaque rupture (36 vs. 46%, p=0.174) and lipid-rich plaque (47 vs. 64%, p=0.011) was rather lower in the higher hsCRP group than in the lower hsCRP group (Figure). In a multivariate analysis, fibrocalcific plaque (odds ratio [OR]: 2.098, 95% confidence interval [CI]: 1.125–3.913, p=0.019), lesion length (mm, OR: 1.036, 95% CI: 1.010–1.061, p=0.004) and current smoker (OR: 2.757, 95% CI: 1.388–5.476, p=0.003) was independently associated with higher hsCRP level. Conclusions ACS patients with high hsCRP levels had more fibrocalcific plaque and longer lesion than those with low hsCRP levels. The association between high hsCRP levels and vulnerable characteristics of culprit plaque was not demonstrated. Funding Acknowledgement Type of funding source: None

Sign in / Sign up

Export Citation Format

Share Document