scholarly journals Efficacy of serum miRNA test as a non-invasive method to diagnose nonalcoholic steatohepatitis: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shengliang Xin ◽  
Qiao Zhan ◽  
Xiaofan Chen ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Systematic Review ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Non Invasive ◽  
Serum Mirna ◽  
Invasive Method

Efficacy of serum miRNA test as a non-invasive method to diagnose nonalcoholic steatohepatitis: a systematic review and meta-analysis.

2020 ◽  
Author(s):  
Shengliang Xin ◽  
Qiao Zhan ◽  
Xiaofan Chen ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Systematic Review ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Diagnostic Efficacy ◽  
Non Invasive ◽  
Serum Mirna ◽  
Serum Mirnas ◽  
Invasive Method ◽  
Meta Regression ◽  
Sensitivity Specificity

Abstract 1. Background: Nonalcoholic steatohepatitis (NASH) is a key turning point during the progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have shown that serum miRNA tests may be effective in the diagnosis of NAFLD. We conducted a meta-analysis to assess the evidence for the diagnostic efficacy of serum miRNAs in patients with NAFLD and its subtype, NASH, in particular. 2. Methods: After a systematic review, sensitivity, specificity, and area under the receiver operating characteristics curve (AUROC) were pooled to determine the efficacy of serum miRNA test for the diagnosis of NAFLD and NASH. Clinical utility was evaluated by Fagan’s nomogram and likelihood ratio scattergram. Heterogeneity was evaluated by subgroup analysis and meta-regression. Publication bias was detected by Deeks’ funnel plot. 3. Results: We included 27 trials containing 1775 NAFLD patients (including simple steatosis and NASH) and 586 NASH patients. For NAFLD vs NASH, the pooled sensitivity, specificity, and AUROC were (0.71 vs. 0.74), (0.76 vs. 0.85) and (0.80 vs. 0.86), respectively. Serum miRNA had high accuracy for distinguishing NASH from simple steatosis, with an AUROC of 0.91. Among the most commonly studied serum miRNAs , miRNA-34a showed moderate diagnostic accuracy for NAFLD and the lowest heterogeneity (sensitivity I 2 = 5.73%, specificity I 2 = 33.16%, AUROC = 0.85). According to subgroup analysis and meta-regression, a lower BMI ( < 30 kg/m 2 ) might be a crucial source of heterogeneity. 4.Conclusions: As a novel non-invasive method, serum miRNA test exhibited robust diagnostic efficacy for NASH. Among these well-studied miRNAs, miRNA-34a was more available for diagnosis. Diagnosis of NAFLD by serum miRNA is more likely to be accurate in patients with BMI ≥ 30kg/m 2 .

Diagnostic efficacy of serum miRNA as a non-invasive method for nonalcoholic steatohepatitis: a systematic review and meta-analysis.

2020 ◽  
Author(s):  
Shengliang Xin ◽  
Qiao Zhan ◽  
Xiaofan Chen ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Subgroup Analysis ◽  
Operating Characteristics ◽  
Diagnostic Efficacy ◽  
Simple Steatosis ◽  
Non Invasive ◽  
Serum Mirna ◽  
Serum Mirnas ◽  
Invasive Method ◽  
Meta Regression

Abstract 1. Background: Nonalcoholic steatohepatitis (NASH) is a key turning point in the progression of nonalcoholic fatty liver disease (NAFLD). As a non-invasive method , serum miRNA levels may provide an effective reference for the diagnosis of NASH. This article systematically reviewed related diagnostic trials to compare the difference in the efficacy of serum miRNAs in the diagnosis of NAFLD and its subtype, NASH, and identify the influencing factors. 2. Methods: We pooled the sensitivity (SEN), specificity (SPE), and area under receiver operating characteristics (AUROC) of each trail to determine the efficacy of serum miRNAs in the diagnosis of NAFLD and NASH; Clinical utility was evaluated by Fagan`s nomogram; Heterogeneity was evaluated by subgroup analysis and meta-regression. Publication bias was detected by Deek’s funnel plot. 3. Results: We included 9 articles consisting of 27 trials and 2361 cases, 1775 NAFLD patients (not distinguishing between simple steatosis and NASH) and 586 NASH patients were collected. All cases were confirmed by biopsy. For NAFLD and NASH, the pooled values were SEN (0.71 vs. 0.74), SPE (0.76 vs. 0.85) and AUROC (0.80 vs. 0.86). miRNA had a high accuracy in distinction NASH from simple steatosis with AUROC at 0.91. Among the well-studied serum miRNAs, miRNA-34a showed a moderate accuracy with the lowest heterogeneity in diagnosing NAFLD (SPE I 2 : 5.73%, SPE I 2 : 33.16%, AUROC: 0.85). According to subgroup analysis and meta-regression, lower BMI ( <30kg/m 2 ) may be a crucial source of heterogeneity and reduced the performance of serum miRNA in the diagnosis of NAFLD. 4. Conclusions: As a non-invasive method, serum miRNA should be considered a promising parameter in the diagnosis of NASH. Generally, NAFLD patients with higher BMI ( ≥ 30kg/m 2 ) are more likely to be diagnosed accurately by serum miRNA.

scholarly journals Platelet-rich plasma: Its applications in orthodontics – A systematic review

2021 ◽  
Vol 11 ◽  
pp. 235-246
Author(s):  
Kanchan Prafulla Narkhede ◽  
Wasundhara Bhad ◽  
Santosh J. Chavan
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Tooth Movement ◽  
Platelet Rich Plasma ◽  
Human Subjects ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Non Invasive ◽  
Invasive Method

Objectives: The aim of this systematic review was to assess the available literature for the effects of platelet-rich plasma (PRP) in orthodontics. Material and Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (PRISMA). The following databases were searched up to May 2020: Medline (through PubMed), Cochrane, and Google Scholar, and reference lists of the included studies were screened. Randomized controlled trials (RCTs) and controlled clinical trials using PRP an adjunct with the standard orthodontic procedures including animal and human subjects as participants were included in the study. The quality of the included human RCTs was assessed per the revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0), whereas the risk of bias of the included animal studies was assessed using SYRCLES’s RoB tool. Results: Eight studies, six animal and two human studies, fulfilled the inclusion criteria. Three animal studies and one human RCT reported that PRP increased the rate of tooth movement when used as an adjunct along with orthodontic treatment. Conclusion: According to the currently available literature, PRP is an efficient non-invasive method of tooth acceleration, but as most of the studies carried are on animals and cannot be applied to humans indistinctly.

Simple non‐invasive scoring systems and histologic scores in predicting mortality in NAFLD patients: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Chang‐Hai Liu ◽  
Javier Ampuero ◽  
Michael Pavlides ◽  
Vincent Wai‐Sun Wong ◽  
Jian‐Gao Fan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Scoring Systems ◽  
Non Invasive

scholarly journals Revisiting an Old Conundrum: A Systematic Review and Meta-Analysis of Intravesical Therapy for Treatment of Urothelial Carcinoma of the Prostate

2021 ◽  
pp. 1-10
Author(s):  
Andrea Kokorovic ◽  
Mary E. Westerman ◽  
Kate Krause ◽  
Mike Hernandez ◽  
Nathan Brooks ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urothelial Carcinoma ◽  
Meta Analysis ◽  
Complete Response ◽  
Intravesical Therapy ◽  
Cochrane Library ◽  
Carcinoma Of The Prostate ◽  
Non Invasive ◽  
Bcg Therapy ◽  
Mucosal Involvement

BACKGROUND: The optimal management of non-invasive (mucosal and/or ductal) urothelial carcinoma of the prostate remains elusive and there is a paucity of data to guide treatment. OBJECTIVE: Our objective was to systematically review and synthesize treatment responses to conservative management of non-invasive prostatic urothelial carcinoma using intravesical therapy. METHODS: A systematic literature search using MEDLINE, EMBASE, Cochrane Library, SCOPUS, and Web of Science databases from inception to November 2019 was performed. Risk of bias assessment was performed using the Newcastle-Ottawa scale for non-randomised studies. Pooled estimates of complete response in the bladder and prostate and prostate only were performed using a random effects model. Pre-specified subgroup analyses were generated to assess differences in complete responses for: BCG therapy vs other agents, ductal vs mucosal involvement, CIS vs papillary tumors and TURP vs no TURP. RESULTS: Nine studies including 175 patients were identified for inclusion in the systematic review and meta-analysis. All were retrospective case series and most evaluated response to BCG therapy. The pooled global complete response rate for intravesical therapy was 60%(95%CI: 0.48, 0.72), and for prostate 88%(95%CI: 0.81, 0.96). Pre-specified analyses did not demonstrate statistically significant differences between subgroups of interest. CONCLUSIONS: Management of non-invasive prostatic urothelial carcinoma using intravesical therapy yields satisfactory results. Caution should be taken in treating patients with papillary tumors and ductal involvement, as data for these populations is limited. TURP may not improve efficacy, but is required for staging. Current recommendations are based on low quality evidence, and further research is warranted.

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