Efficacy of serum miRNA test as a non-invasive method to diagnose nonalcoholic steatohepatitis: a systematic review and meta-analysis.

2020 ◽  
Author(s):  
Shengliang Xin ◽  
Qiao Zhan ◽  
Xiaofan Chen ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Systematic Review ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Diagnostic Efficacy ◽  
Non Invasive ◽  
Serum Mirna ◽  
Serum Mirnas ◽  
Invasive Method ◽  
Meta Regression ◽  
Sensitivity Specificity

Abstract 1. Background: Nonalcoholic steatohepatitis (NASH) is a key turning point during the progression of nonalcoholic fatty liver disease (NAFLD). Recent studies have shown that serum miRNA tests may be effective in the diagnosis of NAFLD. We conducted a meta-analysis to assess the evidence for the diagnostic efficacy of serum miRNAs in patients with NAFLD and its subtype, NASH, in particular. 2. Methods: After a systematic review, sensitivity, specificity, and area under the receiver operating characteristics curve (AUROC) were pooled to determine the efficacy of serum miRNA test for the diagnosis of NAFLD and NASH. Clinical utility was evaluated by Fagan’s nomogram and likelihood ratio scattergram. Heterogeneity was evaluated by subgroup analysis and meta-regression. Publication bias was detected by Deeks’ funnel plot. 3. Results: We included 27 trials containing 1775 NAFLD patients (including simple steatosis and NASH) and 586 NASH patients. For NAFLD vs NASH, the pooled sensitivity, specificity, and AUROC were (0.71 vs. 0.74), (0.76 vs. 0.85) and (0.80 vs. 0.86), respectively. Serum miRNA had high accuracy for distinguishing NASH from simple steatosis, with an AUROC of 0.91. Among the most commonly studied serum miRNAs , miRNA-34a showed moderate diagnostic accuracy for NAFLD and the lowest heterogeneity (sensitivity I 2 = 5.73%, specificity I 2 = 33.16%, AUROC = 0.85). According to subgroup analysis and meta-regression, a lower BMI ( < 30 kg/m 2 ) might be a crucial source of heterogeneity. 4.Conclusions: As a novel non-invasive method, serum miRNA test exhibited robust diagnostic efficacy for NASH. Among these well-studied miRNAs, miRNA-34a was more available for diagnosis. Diagnosis of NAFLD by serum miRNA is more likely to be accurate in patients with BMI ≥ 30kg/m 2 .

Diagnostic efficacy of serum miRNA as a non-invasive method for nonalcoholic steatohepatitis: a systematic review and meta-analysis.

2020 ◽  
Author(s):  
Shengliang Xin ◽  
Qiao Zhan ◽  
Xiaofan Chen ◽  
Jinghang Xu ◽  
Yanyan Yu
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Subgroup Analysis ◽  
Operating Characteristics ◽  
Diagnostic Efficacy ◽  
Simple Steatosis ◽  
Non Invasive ◽  
Serum Mirna ◽  
Serum Mirnas ◽  
Invasive Method ◽  
Meta Regression

Abstract 1. Background: Nonalcoholic steatohepatitis (NASH) is a key turning point in the progression of nonalcoholic fatty liver disease (NAFLD). As a non-invasive method , serum miRNA levels may provide an effective reference for the diagnosis of NASH. This article systematically reviewed related diagnostic trials to compare the difference in the efficacy of serum miRNAs in the diagnosis of NAFLD and its subtype, NASH, and identify the influencing factors. 2. Methods: We pooled the sensitivity (SEN), specificity (SPE), and area under receiver operating characteristics (AUROC) of each trail to determine the efficacy of serum miRNAs in the diagnosis of NAFLD and NASH; Clinical utility was evaluated by Fagan`s nomogram; Heterogeneity was evaluated by subgroup analysis and meta-regression. Publication bias was detected by Deek’s funnel plot. 3. Results: We included 9 articles consisting of 27 trials and 2361 cases, 1775 NAFLD patients (not distinguishing between simple steatosis and NASH) and 586 NASH patients were collected. All cases were confirmed by biopsy. For NAFLD and NASH, the pooled values were SEN (0.71 vs. 0.74), SPE (0.76 vs. 0.85) and AUROC (0.80 vs. 0.86). miRNA had a high accuracy in distinction NASH from simple steatosis with AUROC at 0.91. Among the well-studied serum miRNAs, miRNA-34a showed a moderate accuracy with the lowest heterogeneity in diagnosing NAFLD (SPE I 2 : 5.73%, SPE I 2 : 33.16%, AUROC: 0.85). According to subgroup analysis and meta-regression, lower BMI ( <30kg/m 2 ) may be a crucial source of heterogeneity and reduced the performance of serum miRNA in the diagnosis of NAFLD. 4. Conclusions: As a non-invasive method, serum miRNA should be considered a promising parameter in the diagnosis of NASH. Generally, NAFLD patients with higher BMI ( ≥ 30kg/m 2 ) are more likely to be diagnosed accurately by serum miRNA.

scholarly journals Rationale and prognosis of repurposed drugs with risk stratification of COVID-19 patients requiring Oxygen supplementation: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Esther Jebarani Elangovan ◽  
Vanitha Shyamili Kumar ◽  
Adhithyan Kathiravan ◽  
Raghav Mallampalli ◽  
Tiju Thomas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mortality Rate ◽  
Lung Disease ◽  
Meta Analysis ◽  
Comorbid Condition ◽  
Marginal Effect ◽  
Eligibility Criteria ◽  
Non Invasive ◽  
Clinical Benefits ◽  
Meta Regression

AbstractBackgroundThe rising number of trials on repurposed dugs in COVID-19 has led to duplication and a need for curation of available outcomes from treatments that have been followed across the world. We have conducted a systematic review and meta-analysis that focus on evaluating the clinical outcomes of repurposed interventions against COVID-19.MethodsRandom effects model was adopted to estimate overall treatment effect and heterogeneity. Meta- regression was performed to study the correlation between comorbid conditions and non- invasive or invasive ventilation requirement.ResultsTwenty-nine articles met our eligibility criteria. In subgroup analysis, Tocilizumab was highly significant with lower mortality rate (OR 27.50; 95%CI [5.39-140.24]) of severe COVID-19 patients. Hydroxychloroquine and Lopinavir-ritonavir was found to be inefficacious in severe patients (OR 0.64; 95%CI [0.47-0.86] and 1.40 [0.71-2.76]). Dexamethasone had marginal effect on overall mortality rate (OR 1.19; 95%CI [1.05-1.35]). The meta-regression shows a positive correlation between prevalence of patients on Tocilizumab in non invasive support and hypertension condition (P = 0.02), whereas a negative correlation was identified with patients having lung disease (P = 0.03).ConclusionOverall, our study confirmed that tocilizumab may probably reduce the mortality rate (<10%) of severe COVID-19 patients than other interventions. Further, reduce the risk of requiring non- invasive ventilator support in patients with comorbid condition of lung disease. Hydroxychloroquine and Lopinavir-ritonavir has no clinical benefits in severe COVID-19. A high quality evidence is required to evaluate the usage of Serpin + Favipiravir combination in severe or critical COVID-19.

scholarly journals Abnormally Expressed Circular RNAs as Novel Non-Invasive Biomarkers for Hepatocellular Carcinoma: A Pair-wise Meta-Analysis

2019 ◽  
Author(s):  
Yanlin Jiang ◽  
Mengmeng Shang ◽  
Shizhen Dong ◽  
Menglu Chen ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Meta Analysis ◽  
Area Under The Curve ◽  
Circular Rnas ◽  
Sample Type ◽  
Analysis Model ◽  
Diagnostic Efficacy ◽  
Non Invasive ◽  
Trim And Fill ◽  
Sensitivity Specificity

Abstract Background: In the recent literature, dysregulated circular RNAs (circRNAs) have been extensively investigated in hepatocellular carcinoma (HCC). This study strives to evaluate the diagnostic as well as the predictive value of abnormally expressed circRNAs in HCC. Methods: Eligible studies were sourced from PubMed, EMBASE, and CNKI online databases. Data on patients’ clinical characteristics, including diagnostic efficacy and overall survival (OS) were extracted. The diagnostic and prognostic parameters were respectively synthesized using the bivariate meta-analysis model and multivariate Cox hazard regression analysis based on STATA 12.0. The trim and fill approach was employed to evaluate the impacts of publication bias. Results: A sum of 21 eligible types of research was incorporated. The pooled sensitivity, specificity and area under the curve (AUC) of abnormally expressed circRNAs in distinguishing HCC from non-cancer controls were estimated to be 0.78 (95% confidence interval (CI): 0.69–0.85), 0.80 (95% CI: 0.74–0.86) and 0.86, respectively. Survival analyses expressed that the down-regulated circRNA expression signature correlated perfectly with HCC survival (hazard ratio (HR) = 0.42, 95% CI: 0.19–0.91, p = 0.028; I2 = 92.7%; p = 0.000), whereas the HCC cases with high circRNA levels had significantly poorer prognoses than those of patients with low circRNA levels (HR = 2.22, 95% CI: 1.50–3.30, p = 0.000; I2 = 91%; p = 0.000). Moreover, abnormally expressed circRNAs were intimately linked with tumor size, differentiation grade, microvascular invasion, metastasis, TNM stage, and serum AFP level in patients with HCC. Stratified analysis based on sample type, control source, and expression status also yielded robust results. Conclusions: Abnormally expressed circRNA signatures show immense potential as novel non-invasive biomarker(s) in complementing HCC diagnosis and prognosis.

Narrow-band imaging in the diagnosis of deep submucosal colorectal cancers: a systematic review and meta-analysis

Endoscopy ◽  
2017 ◽  
Vol 49 (06) ◽  
pp. 564-580 ◽  
Author(s):  
Qing-Wei Zhang ◽  
La-Mei Teng ◽  
Xin-Tian Zhang ◽  
Jing-Jing Zhang ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Colorectal Cancers ◽  
Diagnostic Efficacy ◽  
Subgroup Analyses ◽  
Meta Regression ◽  
Sensitivity Specificity

Abstract Background and aims Magnifying endoscopy with narrow-band imaging (M-NBI) has been widely used in the differential diagnosis of deep submucosal colorectal cancers (dSMCs) from superficial submucosal cancers (sSMCs) and intramucosal neoplasms. We aimed to pool the diagnostic efficacy of M-NBI and compare it with that of magnifying chromoendoscopy (M-CE) in diagnosing colorectal dSMC. Methods PubMed, EMBASE, and the Cochrane Library were searched to identify eligible studies. Meeting abstracts were also searched. A bivariate mixed-effects binary regression model was used in the meta-analysis to calculate the pooled diagnostic efficacy of M-NBI and compare it with that of M-CE in the diagnosis of dSMC. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Results We included 17 studies: 14 full texts and 3 meeting abstracts. The pooled sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUC) with 95 % confidence intervals (CIs) in diagnosing dSMC were 74 % (66 % – 81 %; I2 = 84.6 %), 98 % (94 % – 99 %; I2 = 94.4 %), and 0.91 (0.88 – 0.93), respectively, for M-NBI. The pooled sensitivity, specificity and AUC (95 %CI) were 84 % (76 % – 89 %; I2 = 76.9 %), 97 % (94 % – 99 %; I2 = 90.2 %), and 0.97 (0.95 – 0.98), respectively, for M-CE. M-NBI had lower sensitivity (P < 0.01) than M-CE with similar specificity (P = 0.32). Subgroup analyses and meta-regression indicated that endoscopic diagnostic criteria, study type, endoscope type, risk of index test bias, and histopathological diagnostic criteria might be the sources of heterogeneity. Conclusions M-NBI and M-CE had comparable specificities in diagnosing dSMC, but the sensitivity of M-NBI was slightly lower than that of M-CE.

scholarly journals Platelet-rich plasma: Its applications in orthodontics – A systematic review

2021 ◽  
Vol 11 ◽  
pp. 235-246
Author(s):  
Kanchan Prafulla Narkhede ◽  
Wasundhara Bhad ◽  
Santosh J. Chavan
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Tooth Movement ◽  
Platelet Rich Plasma ◽  
Human Subjects ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Non Invasive ◽  
Invasive Method

Objectives: The aim of this systematic review was to assess the available literature for the effects of platelet-rich plasma (PRP) in orthodontics. Material and Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (PRISMA). The following databases were searched up to May 2020: Medline (through PubMed), Cochrane, and Google Scholar, and reference lists of the included studies were screened. Randomized controlled trials (RCTs) and controlled clinical trials using PRP an adjunct with the standard orthodontic procedures including animal and human subjects as participants were included in the study. The quality of the included human RCTs was assessed per the revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0), whereas the risk of bias of the included animal studies was assessed using SYRCLES’s RoB tool. Results: Eight studies, six animal and two human studies, fulfilled the inclusion criteria. Three animal studies and one human RCT reported that PRP increased the rate of tooth movement when used as an adjunct along with orthodontic treatment. Conclusion: According to the currently available literature, PRP is an efficient non-invasive method of tooth acceleration, but as most of the studies carried are on animals and cannot be applied to humans indistinctly.

scholarly journals Non-invasive and minimally invasive glucose monitoring devices: a systematic review and meta-analysis on diagnostic accuracy of hypoglycaemia detection

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nicole Lindner ◽  
Aya Kuwabara ◽  
Tim Holt
Keyword(s):  
Systematic Review ◽  
Diagnostic Accuracy ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Glucose Monitoring ◽  
Cochrane Library ◽  
Monitoring Systems ◽  
Invasive Monitoring ◽  
Non Invasive ◽  
Meta Regression

Abstract Background The use of minimally and non-invasive monitoring systems (including continuous glucose monitoring) has increased rapidly over recent years. Up to now, it remains unclear how accurate devices can detect hypoglycaemic episodes. In this systematic review and meta-analysis, we assessed the diagnostic accuracy of minimally and non-invasive hypoglycaemia detection in comparison to capillary or venous blood glucose in patients with type 1 or type 2 diabetes. Methods Clinical Trials.gov, Cochrane Library, Embase, PubMed, ProQuest, Scopus and Web of Science were systematically searched. Two authors independently screened the articles, extracted data using a standardised extraction form and assessed methodological quality using a review-tailored quality assessment tool for diagnostic accuracy studies (QUADAS-2). The diagnostic accuracy of hypoglycaemia detection was analysed via meta-analysis using a bivariate random effects model and meta-regression with regard to pre-specified covariates. Results We identified 3416 nonduplicate articles. Finally, 15 studies with a total of 733 patients were included. Different thresholds for hypoglycaemia detection ranging from 40 to 100 mg/dl were used. Pooled analysis revealed a mean sensitivity of 69.3% [95% CI: 56.8 to 79.4] and a mean specificity of 93.3% [95% CI: 88.2 to 96.3]. Meta-regression analyses showed a better hypoglycaemia detection in studies indicating a higher overall accuracy, whereas year of publication did not significantly influence diagnostic accuracy. An additional analysis shows the absence of evidence for a better performance of the most recent generation of devices. Conclusion Overall, the present data suggest that minimally and non-invasive monitoring systems are not sufficiently accurate for detecting hypoglycaemia in routine use. Systematic review registration PROSPERO 2018 CRD42018104812

Systematic review and meta-analysis of Altruistic and Game-playing Love

2020 ◽  
Author(s):  
Hossein Dabiriyan Tehrani ◽  
Sara Yamini
Keyword(s):  
Systematic Review ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Game Playing ◽  
Love Styles ◽  
Collectivistic Culture ◽  
Meta Regression ◽  
Collectivistic Cultures ◽  
The Relationship

This systematic review aimed to find attitudes toward Altruistic and Game-playing love styles across individualistic and collectivistic cultures. Addressing major moderators concerning Altruistic and Game-playing love styles are the secondary objectives of this review. This review included 102 articles comprising samples from 37 countries (N = 41997). The findings of this meta-analysis show that there is a collectivistic and individualistic difference in Game-playing but not in the Altruistic love style. Collectivistic and individualistic cultures, on average, demonstrate the same perception concerning the Altruistic love style, whereas collectivistic culture shows the Game-playing love style more strongly. To explain the role of moderators in key measures, the subgroup analysis and meta-regression show that both Game-playing and Altruistic love styles decline by increasing the length of the relationship. Likewise, having children affects these love styles such that the Altruistic love style is improved, and the Game-playing love style is reduced by the presence of children in families.

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