scholarly journals The geriatric nutritional risk index mediated the relationship between serum uric acid and hypertension: a mediation analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhongnan Cao ◽  
Sui Dai ◽  
Xun Liu
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Risk Index ◽  
Mediation Effect ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Increased Risk ◽  
Nutritional Risk Index ◽  
The Relationship

Abstract Background The elevated serum uric acid (SUA) is associated with an increased risk of hypertension and nutritional status. Malnutrition might modify the association of SUA with hypertension. Therefore, the aims of this study were to examine the mediation effect of malnutrition on the association of SUA with the risk of hypertension in Chinese population. Methods The study was based on the China Health and Nutrition Survey in 2009. Participants aged ≥ 60 years with complete analyzed data were eligible. The Geriatric Nutritional Risk Index (GNRI) was calculated by serum albumin (ALB) and BMI. Participants were identified as hypertension if systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg or receiving antihypertensive drug. Results There were 2371 participants included in the final analysis. In total, there was a significant mediation effect of the GNRI on the relationship between SUA level with hypertension (P < 0.001; OR: 1.096; and 95 % CI: 1.048–1.146). And the proportion mediated was 17.77 %. The results stratified by sex were consistent with those of total population. The significant mediation effects of the GNRI were found in the 60–69 years and 70–79 years groups (P = 0.002 and 0.032; OR: 1.099 and 1.075; and 95 % CI: 1.036–1.165 and 1.006–1.148, respectively) but not in the 80–99 years group (P = 0.303). The proportions mediated were16.22 % and 18.36 %, respectively. Conclusions The GNRI can mediate and account for approximately 17.77 % of the relationship between SUA level and the risk of hypertension. And this mediation effect was fully observed in both males and females, especially in the 60–79 years population.

scholarly journals Lower Geriatric Nutritional Risk Index Are Associated With A Higher Incidence Of Osteoporosis In Northern China Type 2 Diabetes

2021 ◽  
Author(s):  
Yuan yuan Ji ◽  
Nan Geng ◽  
Yingchun Niu ◽  
Hang Zhao ◽  
Wenjie Fei ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Operating Characteristic ◽  
Risk Index ◽  
Northern China ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index ◽  
The Relationship ◽  
Spearman’S Correlation

Abstract Introduction Geriatric Nutrition Risk Index（GNRI）assesses the risk of malnutrition and complications associated with nutritional status in older patients and is also an important predictor of many diseases. Osteoporosis is very general in the elderly population and can cause fractures and disability. Malnutrition is associated with osteoporosis. Therefore, we investigated the relationship between GNRI and osteoporosis in T2DM.Methods Study population of 610 patients with T2DM, collect general and laboratory data on the patient and measure BMD; GNRI is calculated based on serum albumin levels, actual weight and ideal weight. Spearman's correlation analysis, logistic regression analysis, receiver operating characteristic (ROC) curves were used to explore the relationship between GNRI and bone metabolism-related indicators.Results Spearman's correlation analysis yielded a positive correlation between GNRI and BMD, and a negative correlation between GNRI and ALP and PINP. After adjustment of age, duration of illness, TC, TG and uric acid et al confounding factors, a positively correlated with 25(OH)D and PTH (r=0.224, r=0.136, respectively) and negative correlation was found between GNRI and ALP and PINP (r=-0.178, r=-0.120, respectively). Regression analysis yields, GNRI was significantly associated with osteoporosis (in the age < 65 years group, odds ratio was 0.917, P < 0.05 and in the age≥65 years group, was 1.062, P<0.05). The area under the curve of the GNRI recipient operating characteristic curve was 0.584, and the optimal threshold for GNRI to assess the occurrence of osteoporosis was 107.2, the sensitivity was 89.63% and the specificity was 24.63%.Conclusions: Lower Geriatric Nutritional Risk Index among type 2 diabetic patients in northern China are associated with a higher Incidence of osteoporosis.

scholarly journals The Geriatric Nutritional Risk Index Independently Predicts Mortality in Diabetic Foot Ulcers Patients Undergoing Amputations

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yuanyuan Xie ◽  
Hailing Zhang ◽  
Tingting Ye ◽  
Shengjie Ge ◽  
Ruyi Zhuo ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Hazard Analysis ◽  
Risk Index ◽  
Nutritional Risk ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Geriatric Nutritional Risk Index ◽  
Increased Risk ◽  
Nutritional Risk Index ◽  
Artery Disease

Objective. Patients with diabetic foot ulcers undergoing amputations have poor prognosis. Malnutrition usually occurs in this population and is associated with increased risk of mortality. The geriatric nutritional risk index (GNRI) is a widely used, simple, and well-established tool to assess nutritional risk. The purpose of this study was to assess the association between GNRI and all-cause mortality in diabetic foot ulcers patients undergoing minor or major amputations.Methods. This was a retrospective cohort study including 271 adult patients. Patients were divided into two groups according to a GNRI cutoff value of 92, and characteristics and mortality were compared between the two groups. Cox proportional hazard analysis was performed to explore the association between GNRI and mortality.Result. GNRI (p<0.001), age (p<0.001), and eGFR (p=0.002) were independent predictors of mortality. Among a subgroup of 230 patients with minor amputation, increased age (p<0.001), coronary artery disease (p=0.030), and increased GNRI (p<0.001) were major risk factors.Conclusion. GNRI on admission might be a novel clinical predictor for the incidence of death in patients with diabetic foot ulcers who were undergoing amputations.

scholarly journals Association of the Geriatric Nutritional Risk Index with incident hypertension in the older Chinese population: a 6-year cohort study

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110100
Author(s):  
Zhongjian Su ◽  
Xing Zhang ◽  
Nan Zheng ◽  
Ying Xiao ◽  
Xingzhu Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Index ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutrition Survey ◽  
Actual Weight ◽  
Health And Nutrition ◽  
Nutritional Risk Index ◽  
Older Chinese ◽  
Study Participants

Background We examined the association of the Geriatric Nutritional Risk Index (GNRI) with the incidence of hypertension. Methods We used data of the China Health and Nutrition Survey in this study. Participants aged ≥60 years were eligible. The GNRI was defined as follows: GNRI = [1.489 × albumin (ALB; g/L)] + [41.7 × (actual weight/ideal weight)]. Participants with systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive medication were defined as having hypertension. Results This study included 4853 participants, comprising 3612 control participants and 1241 participants with hypertension. The GNRI, ALB, and body mass index (BMI) were significantly associated with higher incidence of hypertension (HR: 1.030, 1.026, and 1.088; 95% CI: 1.020–1.041, 1.008–1.044, and 1.069–1.107, respectively). The GNRI, ALB, and BMI were associated with an earlier age of hypertension onset (β = −0.403, −0.613, and −0.321; 95% CI: −0.493 to −0.314, −0.767 to −0.459, and −0.484 to −0.159, respectively). Conclusions A higher GNRI was associated with increased incidence of hypertension. An elevated GNRI was associated with earlier age of hypertension onset.

scholarly journals Combined Predictive Value of Extracellular Fluid/Intracellular Fluid Ratio and the Geriatric Nutritional Risk Index for Mortality in Patients Undergoing Hemodialysis

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2659 ◽  
Author(s):  
Takahiro Yajima ◽  
Kumiko Yajima ◽  
Hiroshi Takahashi ◽  
Keigo Yasuda
Keyword(s):  
Risk Model ◽  
Risk Index ◽  
Survival Rates ◽  
Extracellular Fluid ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Protein Energy Wasting ◽  
Intracellular Fluid ◽  
Net Reclassification Improvement ◽  
Nutritional Risk Index

The ratio of extracellular fluid (ECF) to intracellular fluid (ICF) may be associated with mortality in patients undergoing hemodialysis, possibly associated with protein-energy wasting. We therefore investigated the relationship of the ECF/ICF ratio and the geriatric nutritional risk index (GNRI) with the all-cause and cardiovascular-specific mortality in 234 patients undergoing hemodialysis. Bioimpedance analysis of the ECF and ICF was performed and the ECF/ICF ratio was independently associated with GNRI (β = −0.247, p < 0.0001). During a median follow-up of 2.8 years, 72 patients died, of which 29 were cardiovascular. All-cause mortality was independently associated with a lower GNRI (adjusted hazard ratio [aHR] 3.48, 95% confidence interval [CI] 2.01–6.25) and a higher ECF/ICF ratio (aHR 11.38, 95%CI 5.29–27.89). Next, we divided patients into four groups: group 1 (G1), higher GNRI and lower ECF/ICF ratio; G2, lower GNRI and lower ECF/ICF ratio; G3, higher GNRI and higher ECF/ICF ratio; and G4, lower GNRI and higher ECF/ICF ratio. Analysis of these groups revealed 10-year survival rates of 91.2%, 67.2%, 0%, and 0% in G1, G2, G3, and G4, respectively. The aHR for G4 versus G1 was 43.4 (95%CI 12.2–279.8). Adding the GNRI alone, the ECF/ICF ratio alone, or both to the established risk model improved the net reclassification improvement by 0.444, 0.793 and 0.920, respectively. Similar results were obtained for cardiovascular mortality. In conclusion, the ECF/ICF ratio was independently associated with GNRI and could predict mortality in patients undergoing hemodialysis. Combining the GNRI and ECF/ICF ratio could improve mortality predictions.

scholarly journals Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study

2021 ◽  
Vol 323 ◽  
pp. 30-36
Author(s):  
Shoji Tsuneyoshi ◽  
Yuta Matsukuma ◽  
Yasuhiro Kawai ◽  
Hiroto Hiyamuta ◽  
Shunsuke Yamada ◽  
...  
Keyword(s):  
Cohort Study ◽  
Stroke Risk ◽  
Risk Index ◽  
Hemodialysis Patients ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Nutritional Risk Index

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

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