scholarly journals Patients with Parkinson’s disease predict a lower incidence of colorectal cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hongsheng Fang ◽  
Yunlan Du ◽  
Shuting Pan ◽  
Ming Zhong ◽  
Jiayin Tang
Keyword(s):  
Colorectal Cancer ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cohort Studies ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Recent Theory ◽  
Analysis Model ◽  
Case Control Studies

Abstract Background Recent theory on the “gut-brain axis” suggests a close relationship between the dysfunction of the gut and the disorders of the brain. Methods We performed a systemic literature search followed by a multi-step inclusion selection for all studies on the risk of Colorectal cancer (CRC) in Parkinson’s disease (PD) patients using the following databases: PubMed, EMBASE and WOS. Relative risk (RR) and the 95% confidence intervals (CI) were calculated using either the random-effects model or the fixed-effects meta-analysis model, based on the assessment of heterogeneity. Results Seventeen studies involving a total of 375,964 PD patients and 879,307 cancer patients were included. Independent meta-analyses for cohort studies and case-control studies showed that the overall pooled RR of the cohort studies was 0.78 (0.66–0.91), and that of the case-control studies was 0.78 (0.65–0.94), indicating that patients with PD have a significantly decreased risk for CRC. The significant lower risk is present in both the colon and the rectum subgroups classified by tumor location. Moreover, the risk for CRC is significantly lower in America (RR = 0.58), Europe (RR = 0.82) and Asia (RR = 0.83) compared to the control population. Conclusion The occurrence of CRC was significantly lower in patients with diagnosis of PD.

Mutations in GBA and risk of Parkinson’s disease: a meta-analysis based on 25 case-control studies

2013 ◽  
Vol 35 (8) ◽  
pp. 873-878 ◽  
Author(s):  
Xueye Mao ◽  
Tinghua Wang ◽  
Rong Peng ◽  
Xueli Chang ◽  
Nannan Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Dairy Consumption and Risk of Conventional and Serrated Precursors of Colorectal Cancer: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Li-Lianagzi Guo ◽  
Yu-Ting Li ◽  
Jun Yao ◽  
Li-Sheng Wang ◽  
Wei-Wei Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Studies ◽  
Dairy Products ◽  
Observational Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Dairy Consumption ◽  
Fermented Dairy Products ◽  
Fermented Dairy

Objective. The consumption of dairy is associated with decreased risk of colorectal cancer (CRC), but few studies have assessed the relationship between dairy consumption and precursors of CRC. Therefore, we performed the first meta-analysis to further evaluate this association. Methods. PubMed, Embase, Scopus, and Web of Science databases were searched through July 2020 for observational studies. Study-specific risk estimates for the highest versus lowest category were pooled using the random-effects and fixed-effects model. The methodological quality of included studies was assessed using the ROBINS-I Scale. Results. A total of 12 studies were included (3 cohort studies and 9 case-control studies). Compared with the lowest level consumption, fermented dairy products had a decreased risk of precursors of CRC in both cohort (RR = 0.92 95% CI: 0.87–0.97) and case-control studies (RR = 0.98 95% CI: 0.96–0.99). Total dairy (RR = 0.80 95% CI: 0.68–0.96) and cheese (RR = 0.96 95% CI: 0.93–0.99) consumption was inversely associated with the risk in case-control studies whereas yogurt consumption was inversely associated with the risk in cohort studies (RR = 0.91 95%CI: 0.86–0.96). No significant associations were found for consumption of total milk and non/low-fat milk. For dose-response analyses, evidence of linear association was found in total dairy and yogurt consumption. The risk decreased by 12% for an increment of 200 g/d total dairy consumption (RR = 0.88 95% CI: 0.81–0.95) and decreased by 8% for an increment of 50 g/d yogurt consumption (RR = 0.92 95% CI: 0.85–0.99). Conclusions. Fermented dairy products, specifically yogurt and cheese, were significantly associated with decreased risk of conventional and serrated precursors of colorectal cancer.

scholarly journals Impulse-Control Disorders in Parkinson’s Disease: A Meta-Analysis and Review of Case–Control Studies

2018 ◽  
Vol 9 ◽  
Author(s):  
Helge Molde ◽  
Yasaman Moussavi ◽  
Stine Therese Kopperud ◽  
Aleksander Hagen Erga ◽  
Anita Lill Hansen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Meta Analysis ◽  
Case Control ◽  
Impulse Control Disorders ◽  
Case Control Studies

scholarly journals Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies

2012 ◽  
Vol 16 (2) ◽  
pp. 346-357 ◽  
Author(s):  
Guowei Li ◽  
Defu Ma ◽  
Yumei Zhang ◽  
Wei Zheng ◽  
Peiyu Wang
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Case Control Studies ◽  
The Relationship

AbstractObjectiveSeparate meta-analyses based on case–control and cohort studies have reported different results on the relationship between coffee consumption and colorectal cancer risk. To clarify the effect of coffee intake on colorectal cancer risk, we performed a meta-analysis based on both case–control and cohort studies.DesignReview study.SettingWe identified case–control and cohort studies related to coffee consumption and colorectal cancer risk listed on MEDLINE, the Cochrane Controlled Trials Register, EMBASE, Science Citation Index and PubMed (until May 2011).SubjectsResearch literature on the relationship between coffee consumption and colorectal cancer risk.ResultsTwenty-five case–control (15 522 cases) and sixteen cohort studies (10 443 cases) were included in the meta-analysis. Comparing the highest v. the lowest/non category of coffee consumption, the combined results from case–control studies showed a significant relationship with colorectal cancer (OR = 0·85, 95 % CI 0·75, 0·97) and colon cancer (OR = 0·79, 95 % CI 0·67, 0·95), but not rectal cancer (OR = 0·95, 95 % CI 0·79, 1·15). For cohort studies, there was a slight suggestion of an inverse association with colorectal cancer (relative ratio = 0·94; 95 % CI 0·88, 1·01) and colon cancer (OR = 0·93, 95 % CI 0·86, 1·01), rather than rectal cancer (OR = 0·98, 95 % CI 0·88, 1·09). In subgroup analyses using case–control studies, significant inverse associations were found in females for colorectal cancer and in Europe for colorectal and colon cancer, while the subgroup analyses of cohort studies found that coffee drinks substantially decreased risk of colon cancer only in Asian women.ConclusionsResults from case–control studies suggest coffee consumption can significantly decrease the risks of colorectal cancer and colon cancer, especially in Europe and for females.

The association between the LRRK2 G2385R variant and the risk of Parkinson’s disease: a meta-analysis based on 23 case–control studies

2014 ◽  
Vol 35 (10) ◽  
pp. 1495-1504 ◽  
Author(s):  
Cheng-long Xie ◽  
Jia-Lin Pan ◽  
Wen-Wen Wang ◽  
Yu Zhang ◽  
Su-fang Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis

2021 ◽  
Vol 13 ◽  
Author(s):  
Ting Shen ◽  
Yumei Yue ◽  
Tingting He ◽  
Cong Huang ◽  
Boyi Qu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Meta Analysis ◽  
Gastrointestinal Symptoms ◽  
Short Chain Fatty Acids ◽  
Case Control ◽  
Case Control Studies ◽  
Geographical Regions ◽  
Gut Microbiota Dysbiosis

Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differences of gut microbiota between patients with PD and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control studies detecting gut microbiota in patients with PD and HCs. Mean difference (MD) and 95% confidence interval (CI) were calculated to access alterations in the abundance of certain microbiota families in PD. Fifteen case-control studies were included in this meta-analysis study. Our results showed significant lower abundance levels of Prevotellaceae (MD = −0.37, 95% CI = −0.62 to −0.11), Faecalibacterium (MD = −0.41, 95% CI: −0.57 to −0.24), and Lachnospiraceae (MD = −0.34, 95% CI = −0.59 to −0.09) in patients with PD compared to HCs. Significant higher abundance level of Bifidobacteriaceae (MD = 0.38, 95%; CI = 0.12 to 0.63), Ruminococcaceae (MD = 0.58, 95% CI = 0.07 to 1.10), Verrucomicrobiaceae (MD = 0.45, 95% CI = 0.21 to 0.69), and Christensenellaceae (MD = 0.20, 95% CI = 0.07 to 0.34) was also found in patients with PD. Thus, shared alterations of certain gut microbiota were detected in patients with PD across different geographical regions. These PD-related gut microbiota dysbiosis might lead to the impairment of short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, and intestinal permeability, which contribute to the pathogenesis of PD.

scholarly journals Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094794
Author(s):  
Jie Liu ◽  
Chunrong Li ◽  
Xiaoyang Zhou ◽  
Jian Sun ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Gene Variants ◽  
Case Control Studies ◽  
The Relationship

Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

scholarly journals Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85781 ◽  
Author(s):  
Lin Lu ◽  
Deng-lei Fu ◽  
Hui-qin Li ◽  
Ai-ju Liu ◽  
Ji-huang Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies
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