Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies

Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differences of gut microbiota between patients with PD and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control studies detecting gut microbiota in patients with PD and HCs. Mean difference (MD) and 95% confidence interval (CI) were calculated to access alterations in the abundance of certain microbiota families in PD. Fifteen case-control studies were included in this meta-analysis study. Our results showed significant lower abundance levels of Prevotellaceae (MD = −0.37, 95% CI = −0.62 to −0.11), Faecalibacterium (MD = −0.41, 95% CI: −0.57 to −0.24), and Lachnospiraceae (MD = −0.34, 95% CI = −0.59 to −0.09) in patients with PD compared to HCs. Significant higher abundance level of Bifidobacteriaceae (MD = 0.38, 95%; CI = 0.12 to 0.63), Ruminococcaceae (MD = 0.58, 95% CI = 0.07 to 1.10), Verrucomicrobiaceae (MD = 0.45, 95% CI = 0.21 to 0.69), and Christensenellaceae (MD = 0.20, 95% CI = 0.07 to 0.34) was also found in patients with PD. Thus, shared alterations of certain gut microbiota were detected in patients with PD across different geographical regions. These PD-related gut microbiota dysbiosis might lead to the impairment of short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, and intestinal permeability, which contribute to the pathogenesis of PD.

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Patients with Parkinson’s disease predict a lower incidence of colorectal cancer

BMC Geriatrics ◽

10.1186/s12877-021-02497-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hongsheng Fang ◽

Yunlan Du ◽

Shuting Pan ◽

Ming Zhong ◽

Jiayin Tang

Keyword(s):

Colorectal Cancer ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cohort Studies ◽

Fixed Effects ◽

Meta Analysis ◽

Case Control ◽

Recent Theory ◽

Analysis Model ◽

Case Control Studies

Abstract Background Recent theory on the “gut-brain axis” suggests a close relationship between the dysfunction of the gut and the disorders of the brain. Methods We performed a systemic literature search followed by a multi-step inclusion selection for all studies on the risk of Colorectal cancer (CRC) in Parkinson’s disease (PD) patients using the following databases: PubMed, EMBASE and WOS. Relative risk (RR) and the 95% confidence intervals (CI) were calculated using either the random-effects model or the fixed-effects meta-analysis model, based on the assessment of heterogeneity. Results Seventeen studies involving a total of 375,964 PD patients and 879,307 cancer patients were included. Independent meta-analyses for cohort studies and case-control studies showed that the overall pooled RR of the cohort studies was 0.78 (0.66–0.91), and that of the case-control studies was 0.78 (0.65–0.94), indicating that patients with PD have a significantly decreased risk for CRC. The significant lower risk is present in both the colon and the rectum subgroups classified by tumor location. Moreover, the risk for CRC is significantly lower in America (RR = 0.58), Europe (RR = 0.82) and Asia (RR = 0.83) compared to the control population. Conclusion The occurrence of CRC was significantly lower in patients with diagnosis of PD.

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Selenium and Other Trace Elements in the Etiology of Parkinson’s Disease: A Systematic Review and Meta-Analysis of Case-Control Studies

Neuroepidemiology ◽

10.1159/000502357 ◽

2019 ◽

Vol 54 (1) ◽

pp. 1-23 ◽

Cited By ~ 5

Author(s):

Giorgia Adani ◽

Tommaso Filippini ◽

Bernhard Michalke ◽

Marco Vinceti

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Trace Elements ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies

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Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520947943 ◽

2020 ◽

Vol 48 (8) ◽

pp. 030006052094794

Author(s):

Jie Liu ◽

Chunrong Li ◽

Xiaoyang Zhou ◽

Jian Sun ◽

Meng Zhu ◽

...

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Web Of Science ◽

Meta Analysis ◽

Asian Population ◽

Case Control ◽

Gene Variants ◽

Case Control Studies ◽

The Relationship

Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

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Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease

Parkinson s Disease ◽

10.1155/2018/3201308 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Song-bin He ◽

Chun-yan Liu ◽

Lin-di Chen ◽

Zhi-nan Ye ◽

Ya-ping Zhang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Visual Evoked Potential ◽

Evoked Potential ◽

Meta Analysis ◽

Case Control ◽

Healthy Controls ◽

Case Control Studies ◽

P100 Latency ◽

Visual Evoked

Background. Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson’s disease (PD), but the results were inconsistent. Methods. We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy controls. Case-control studies of PD were selected through an electronic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials. We calculated the pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs) between individuals with PD and controls using the random-effects model. Results. Twenty case-control studies which met our inclusion criteria were included in the final meta-analysis. We found that the P100 latency in PD was significantly higher compared with healthy controls (pooled WMD = 6.04, 95% CI: 2.73 to 9.35, P=0.0003, n=20). However, the difference in the mean amplitude of P100 was not significant between the two groups (pooled WMD = 0.64, 95% CI: −0.06 to 1.33, P=0.07) based on 10 studies with the P100 amplitude values available. Conclusions. The higher P100 latency of VEP was observed in PD patients, relative to healthy controls. Our findings suggest that electrophysiological changes and functional defect in the visual pathway of PD patients are important to our understanding of the pathophysiology of visual involvement in PD.

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Meta-Analysis: Overweight, Obesity, and Parkinson's Disease

International Journal of Endocrinology ◽

10.1155/2014/203930 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Jinhu Chen ◽

Zhenlong Guan ◽

Liqin Wang ◽

Guangyao Song ◽

Boqing Ma ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Meta Analysis ◽

Case Control ◽

Overweight And Obesity ◽

Case Control Studies ◽

Therapeutic Implications ◽

Cockroach Allergen ◽

Significant Difference ◽

Relationship Of

Objective.Parkinson's disease (PD) is a severe neurological disease and its risk factors remain largely unknown. A meta-analysis was carried out to investigate the relationship of overweight and obesity with PD.Methods.We used PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) databases to identify studies of associations between overweight/obesity and PD. Overweight, obesity, and PD were used as keywords, and published works were retrieved until September 30, 2013. The extracted data were classified(BMI≥30,25≤BMI<30, and BMI<25)according to BMI values and analyzed using RevMan5.2 and Stata11.0.Results.Four cohort studies and three case-control studies were used to evaluate the association between overweight/obesity and PD, including 2857 PD patients and 5, 683, 939 cases of non-PD controls. There was a statistically significant difference between25≤BMI<30 and BMI<25in the cohort study (RR=1.17, 95%CI, 1.03–1.32, P=0.03), but there was no difference betweenBMI≥30 and BMI<25orBMI≥30 and 25≤BMI<30, where the respectiveRRwas 1.16 and 0.84; the respective 95%CIwas 0.67–2.01 and 0.61–1.15, respectively, and thePvalues were 0.60 and 0.28, respectively. Case-control studies showed that there was no statistical difference between any two groups.Conclusion.Meta-analysis showed that overweight might be a potential risk factor of PD. Demonstration of a causal role of overweight/obesity in PD development could have important therapeutic implications.Erratum to “Sensitization to Cockroach Allergen: Immune Regulation and Genetic Determinants”

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