Impact of physical exercises on immune function, bone mineral density, and quality of life in people living with HIV/AIDS: a systematic review with meta-analysis

ObjectiveIn this systematic review, we aimed to summarise the empirical evidence on common mental disorders (CMDs), cognitive impairment, frailty and health-related quality of life (HRQoL) among people living with HIV aged ≥50 years (PLWH50 +) residing in sub-Saharan Africa (SSA). Specifically, we document the prevalence and correlates of these outcomes.Design, data sources and eligibility criteriaThe following online databases were systematically searched: PubMed, CINAHL, PsycINFO, Embase and Scopus up to January 2021. English-language publications on depression, anxiety, cognitive function, frailty and quality of life among PLWH50+ residing in SSA were included.Data extraction and synthesisWe extracted information, including study characteristics and main findings. These were tabulated, and a narrative synthesis approach was adopted, given the substantial heterogeneity among included studies.ResultsA total of 50 studies from fifteen SSA countries met the inclusion criteria. About two-thirds of these studies emanated from Ethiopia, Uganda and South Africa. Studies regarding depression predominated (n=26), followed by cognitive impairment (n=13). Overall, PLWH50+ exhibited varying prevalence of depression (6%–59%), cognitive impairments (4%–61%) and frailty (3%–15%). The correlates of CMDs, cognitive impairment, frailty and HRQoL were rarely investigated, but those reported were sociodemographic variables, many of which were inconsistent.ConclusionsThis review documented an increasing number of published studies on HIV and ageing from SSA. However, the current evidence on the mental and well-being outcomes in PLWH50+ is inadequate to characterise the public health dimension of these impairments in SSA, because of heterogeneous findings, few well-designed studies and substantial methodological limitations in many of the available studies. Future work should have sufficiently large samples of PLWH50+, engage appropriate comparison groups, harmonise the measurement of these outcomes using a standardised methodology to generate more robust prevalence estimates and confirm predictors.PROSPERO registration numberCRD42020145791.

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Effect of exercise on bone mineral density and quality of life among postmenopausal women with osteoporosis without fracture: A systematic review

International Journal of Orthopaedic and Trauma Nursing ◽

10.1016/j.ijotn.2020.100796 ◽

2020 ◽

Vol 39 ◽

pp. 100796

Author(s):

D.S. Anupama ◽

Judith A. Norohna ◽

Kiran KV. Acharya ◽

Ravishankar ◽

Anice George

Keyword(s):

Quality Of Life ◽

Bone Mineral Density ◽

Systematic Review ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density

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Impact of HIV-Associated Cognitive Impairment/Functioning On Functional Independence, Frailty And Quality of Life In The Modern Era: A Systematic Review With Meta-Analysis

10.21203/rs.3.rs-1055541/v1 ◽

2021 ◽

Author(s):

Martins Nweke ◽

Mshunqane Nombeko ◽

Nalini Govender ◽

Aderonke O. Akinpelu ◽

Maryjane Ukwuoma

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Cognitive Impairment ◽

Medication Adherence ◽

Health Outcomes ◽

Meta Analysis ◽

Functional Independence ◽

People Living With Hiv ◽

The Impact

Abstract Background: HIV-associated neurocognitive disorder (HAND) is an important sequela of HIV infection. Combined antiretroviral therapy (cART) has improved the health outcomes of many people living with HIV but has given rise to a less severe but limiting form of HAND. The study aimed to evaluate the impact of HAND on medication adherence, activities of daily living (ADL), quality of life and frailty.Methods: This systematic review adheres to the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched MEDLINE, PubMed, CINAHL, Academic Search Complete, and PsycINFO online databases. Studies were included if they examined the relationship between HAND and medication adherence, ADL, quality of life and frailty, and were conducted between 1997 and 2021. We used a random-effects meta-analysis model to assess the impact of HAND on outcome variables.Results: Forty papers, totalling 11540 participants, were included in the narrative and quantitative syntheses. Forty papers were included in the narrative and quantitative syntheses. The 40 studies provided data for 11540 participants. Cognitive impairment was associated with poorer medication adherence (r=0.601, CI 0.338 to 0.776, p =0.001, I2= 94.66). Cognitive impairment did not influence ADL (r=0.167, CI-0.215 to 0.505, p= 0.393) and quality of life (r= 0.244, CI 0.117 to 0.548, p =0.182).Conclusions: In the cART era, HAND appears to be associated with adherence to medication, which may influence future health outcomes. In PLWHIV who are adherent to ART, cognitive impairment does not appear to interfere with ADL and quality of life. Registration: PROSPERO- CRD42021240726.

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Meta Analysis the Association between Social Support and Quality of Life of People Living with HIV/AIDS

Journal of Epidemiology and Public Health ◽

10.26911/jepublichealth.2020.05.04.05 ◽

2020 ◽

Vol 5 (4) ◽

pp. 435-441

Author(s):

Maria Regina Tri Yonita ◽

◽

Setyo Sri Rahardjo ◽

Bhisma Murti ◽

◽

...

Keyword(s):

Quality Of Life ◽

Social Support ◽

Meta Analysis ◽

People Living With Hiv ◽

Living With Hiv ◽

Hiv Aids

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Effect of traditional Chinese medicine (TCM) on survival, quality of life, and immune function in patients with ovarian carcinoma: a systematic review and meta-analysis protocol

10.37766/inplasy2020.11.0104 ◽

2020 ◽

Author(s):

Shuxia Ge ◽

Qianqian Xing ◽

Anqi Zhang ◽

Yucui Wang

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Ovarian Carcinoma ◽

Immune Function ◽

Meta Analysis ◽

Analysis Protocol

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Effect of Social Support on the Quality of Life of People Living with HIV/AIDS: Meta Analisis

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.01.64 ◽

2020 ◽

Author(s):

Maria Regina Tri Yonita ◽

◽

Setyo Sri Rahardjo ◽

Bhisma Murti ◽

◽

...

Keyword(s):

Quality Of Life ◽

Social Support ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Meta Analysis ◽

People Living With Hiv ◽

Randomized Controlled ◽

Living With Hiv ◽

Hiv Aids

Background: Social support is an interpersonal relationship where the social environment provides assistance in the form of emotional attention, instrumental assistance, providing information, appreciation or assessment to individual sufferers. Lack of social support will lead to a decline in physical and mental conditions, so that it can cause a person to be lazy to carry out routine daily self-care activities, as a result people with HIV/AIDS do not adhere to treatment programs. If people with HIV/AIDS do not regularly take anti-retroviral (ARV) for a long time, it will greatly affect the quality of life of people with HIV/AIDS. This study aims to examine the effect of social support on quality of life in people with HIV/AIDS. Subject and Method: Meta analysis was conducted based on PRISMA guidelines on article with randomized controlled trial design which published in 2000-2020. The meta-analysis was carried out by systematically reviewing articles from Google Scholar, PubMed, and Springer Link. The articles used in this research are articles that have been published from 2010-2020. The keywords to find this article are as follows: “social support” AND “quality of life” OR “risk factor” AND “quality of life” OR “quality of life” AND “randomized controlled trial”. Articles are collected using the PRISMA diagram, and analyzed using the Review Manager 5.4 application. Results: There were 6 articles were reviewed in this study which met the criteria. Studies show that social support (OR = 3.14; 95% CI = 1.42 to 6.91; p <0.001) improves quality of life. Conclusion: Social support improves quality of life in people with HIV / AIDS. Keywords: social support, quality of life, people living with HIV / AIDS. Correspondence: Maria Regina Tri Yonita, Master Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: [email protected]

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Effects of telehealth-assisted interventions among people living with HIV/AIDS: A systematic review and meta-analysis of randomized controlled studies

Journal of Telemedicine and Telecare ◽

10.1177/1357633x211070726 ◽

2021 ◽

pp. 1357633X2110707

Author(s):

Ita Daryanti Saragih ◽

Santo Imanuel Tonapa ◽

Charles Peter Osingada ◽

Carolyn M. Porta ◽

Bih-O Lee

Keyword(s):

Quality Of Life ◽

Meta Analysis ◽

Well Being ◽

Future Research ◽

People Living With Hiv ◽

Adherence To Treatment ◽

Randomized Controlled ◽

Living With Hiv ◽

Hiv Aids

Introduction Taking antiretroviral therapy (ART) is a daily necessity for people living with HIV but these individuals experience multiple barriers and challenges to medication adherence. Interventions to support medication adherence have yielded effects in the expected direction, but the extent to which telehealth or virtually delivered interventions to promote adherence are effective among people living with HIV/AIDS remains unknown. We aimed to address this knowledge gap and inform future research and practice that promotes the well-being of people living with HIV/AIDs through telehealth interventions addressing medication use. Methods A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted using the following databases: Academic Search Complete, Cochrane library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, MEDLINE, PubMed, OVID (UpToDate), and the Web of Science. Relevant full-text articles published through September 2021 were retrieved. The revised Cochrane risk of bias tool for randomized trials was used to assess the methodological quality of the included studies. A meta-analysis was performed using a random-effects model to calculate the pooled effects of telehealth-assisted interventions for people living with HIV/AIDS. Stata 16.0 was used for statistical analysis. Results A total of 12 studies (N = 3557 participants) that used telehealth-assisted interventions for people living with HIV/AIDS were included. Telehealth interventions were found to increase the adherence to treatment (standardized mean difference [SMD]: 0.21; 95% confidence interval (CI): 0.03 to 0.40), to reduce depressive symptoms (SMD: −2,74; 95% CI: −3.39 to −2.09), and to improve perceived quality of life (SMD: 0.74; 95% CI: 0.37 to 1.10). Discussion The meta-effects of telehealth-assisted interventions include significantly enhanced adherence to treatment, improved quality of life, and reduced depressive symptoms among people living with HIV/AIDS. These findings suggesting that delivering health management interventions remotely through telehealth-assisted modalities was both feasible and effective in yielding health benefits for people living with HIV/AIDS. Integrating telehealth-assisted interventions as a modality in HIV/AIDS care might support continuity of care and sustained well-being. Future research should evaluate telehealth intervention outcomes and examine mediating, moderating, or other tailorable variables affecting intervention effectiveness.

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