scholarly journals Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dan Yuan ◽  
Meijing Liu ◽  
Yiping Li ◽  
Peng Jia ◽  
Ling Su ◽  
...  
Keyword(s):  
Virologic Failure ◽  
Population Based ◽  
Transmission Networks ◽  
Population Based Study ◽  
Genetic Transmission ◽  
Hiv 1 ◽  
Minority Area

scholarly journals Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China

2021 ◽  
Vol 9 ◽  
Author(s):  
Dan Yuan ◽  
Bin Yu ◽  
Yiping Li ◽  
Zixin Wang ◽  
Meijing Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Molecular Epidemiology ◽  
Transmitted Drug Resistance ◽  
People Living With Hiv ◽  
Newly Diagnosed ◽  
Transmission Networks ◽  
Genetic Transmission ◽  
Living With Hiv ◽  
Hiv 1 ◽  
Minority Area

Introduction: Transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) efficacy. We aimed to understand the molecular epidemiology of TDR and its genetic transmission networks among newly diagnosed people living with HIV/AIDS (PLWH).Methods: A total of 1,318 newly diagnosed PLWH, identified in all population-based HIV screening in an HIV-affected county of a minority area of China (i.e., Butuo county), were enrolled between January 1, 2018, and November 31, 2018. HIV-1 pol gene sequences were used for phylogenetic and genotypic drug resistance analyses. The genetic transmission networks were identified.Results: The prevalence of TDR among newly diagnosed PLWH was 8.12% (107/1,318). Patients in the stage of AIDS (adjusted odds ratio, OR: 2.32) and who had a history of sharing a needle ≥5 times (adjusted OR: 3.89) were more likely to have an increased risk of TDR. The prevalence of TDR for non-nucleoside reverse transcriptase inhibitors (NNRTIs) is higher than that of other inhibitors, with a relatively high prevalence of three mutations [V179D/E/DE (4.93%), K103N/KN (3.11%), and E138A/G (1.52%)]. A total of 577 (43.78%) pol sequences were involved in the genetic transmission network, with 171 clusters ranging in size from 2 to 91 pol sequences; 37.38% (40/107) of individuals carrying TDR were involved in the network, and individuals with the same TDR-associated mutations were usually cross-linked.Conclusions: Our data suggest a relatively high level of TDR and many transmission clusters among the newly diagnosed PLWH. Targeted intervention, early identification, and monitoring of resistance are warranted to reduce the TDR and prevent HIV-1 transmission in areas with a high rate of HIV-1.

In vivo effects of methamphetamine on HIV-1 replication: A population-based study

2016 ◽  
Vol 159 ◽  
pp. 246-254 ◽  
Author(s):  
Junjun Jiang ◽  
Minlian Wang ◽  
Bingyu Liang ◽  
Yi Shi ◽  
Qijian Su ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
In Vivo Effects ◽  
Hiv 1

Genetic transmission networks reveal the transmission patterns of HIV-1 CRF01_AE in China

2017 ◽  
Vol 94 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Xiaoshan Li ◽  
Rong Gao ◽  
Kexin Zhu ◽  
Feiran Wei ◽  
Kun Fang ◽  
...  
Keyword(s):  
Hiv Transmission ◽  
Risk Groups ◽  
Public Health Issue ◽  
Transmission Networks ◽  
Major Public Health Issue ◽  
Genetic Transmission ◽  
Heterosexual Women ◽  
Sex With Men ◽  
Migrant People ◽  
Hiv 1

ObjectivesThe epidemic of HIV-1 CRF01_AE has become a major public health issue in China. This study aimed to characterise the transmission patterns of genetic networks for CRF01_AE nationwide and elucidate possible opportunities for prevention.MethodsWe isolated and conducted genetic transmission network analysis of all available CRF01_AE pol sequences (n=4704) from China in the Los Alamos HIV sequence database.ResultsA total of 1391 (29.6%) sequences were identified as belonging to 400 separate networks. Of men who have sex with men (MSM) in the networks, 93.8% were linked to other MSM and only 2.4% were linked to heterosexual women. However, 11.8% heterosexual women in the networks were linked to MSM. Lineages composed mainly of MSM had higher transmission than those that were mostly heterosexuals. Of the 1391 individuals in networks, 513 (36.9%) were linked to cases diagnosed in different provinces. The proportion of individuals involved in inter-province links was interrelated with the number of migrant people (Spearman’s r=0.738, p=0.001).ConclusionsThe outcome of this study could help improve our ability to understand HIV transmission among various regions and risk groups in China, and highlighted the importance of targeting MSM and migrants by prevention and intervention efforts.

Population-based study of fertility in women with HIV-1 infection in Uganda

The Lancet ◽  
1998 ◽  
Vol 351 (9096) ◽  
pp. 98-103 ◽  
Author(s):  
Ronald H Gray ◽  
Maria J Wawer ◽  
David Serwadda ◽  
Nelson Sewankambo ◽  
Chuanjun Li ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Women With Hiv ◽  
Hiv 1

scholarly journals Effect of HIV‐1 Infection on Antimalarial Treatment Outcomes in Uganda: A Population‐Based Study

2006 ◽  
Vol 193 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Moses R. Kamya ◽  
Anne F. Gasasira ◽  
Adoke Yeka ◽  
Nathan Bakyaita ◽  
Samuel L. Nsobya ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Population Based ◽  
Antimalarial Treatment ◽  
Population Based Study ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document