scholarly journals CCL18-NIR1 promotes oral cancer cell growth and metastasis by activating the JAK2/STAT3 signaling pathway

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao Jiang ◽  
Zhijie Huang ◽  
Xiang Sun ◽  
Xianghuai Zheng ◽  
Jingpeng Liu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Stat3 Signaling ◽  
Oral Cancer Cell ◽  
Stat3 Signaling Pathway

scholarly journals [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway

In Vivo ◽  
2021 ◽  
Vol 35 (6) ◽  
pp. 3193-3201
Author(s):  
HAIBO ZHANG ◽  
EUNGYUNG KIM ◽  
JUNKOO YI ◽  
HUANG HAI ◽  
HYEONJIN KIM ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell

20(S)-Ginsenoside Rh2 Suppresses Oral Cancer Cell Growth by Inhibiting the Src-Raf-ERK Signaling Pathway

2021 ◽  
Vol 41 (1) ◽  
pp. 227-235
Author(s):  
HAIBO ZHANG ◽  
JUNKOO YI ◽  
EUNGYUNG KIM ◽  
YEONSIK CHOO ◽  
HUANG HAI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Erk Signaling ◽  
Ginsenoside Rh2 ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell

A natural product phillygenin suppresses osteosarcoma growth and metastasis by regulating the SHP-1/JAK2/STAT3 signaling

2021 ◽  
Vol 85 (2) ◽  
pp. 307-314
Author(s):  
Xiaomin Ding ◽  
Danqing Lu ◽  
Jianbo Fan
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Janus Kinase ◽  
Potential Candidate ◽  
Osteosarcoma Cell ◽  
Cancer Cell Growth ◽  
Functional Roles ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

ABSTRACT Osteosarcoma represents one of the most devastating cancers due to its high metastatic potency and fatality. Osteosarcoma is insensitive to traditional chemotherapy. Identification of a small molecule that blocks osteosarcoma progression has been a challenge in drug development. Phillygenin, a plant-derived tetrahydrofurofuran lignin, has shown to suppress cancer cell growth and inflammatory response. However, how phillygenin plays functional roles in osteosarcoma has remained unveiled. In this study, we showed that phillygenin inhibited osteosarcoma cell growth and motility in vitro. Further mechanistic studies indicated that phillygenin blocked STAT3 signaling pathway. Phillygenin led to significant downregulation of Janus kinase 2 and upregulation of Src homology region 2 domain-containing phosphatase 1. Gene products of STAT3 regulating cell survival and invasion were also inhibited by phillygenin. Therefore, our studies provided the first evidence that phillygenin repressed osteosarcoma progression by interfering STAT3 signaling pathway. Phillygenin is a potential candidate in osteosarcoma therapy.

scholarly journals Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts

2015 ◽  
Vol 6 (8) ◽  
pp. 877-881 ◽  
Author(s):  
Patricia G. Cruz ◽  
Andrew M. Fribley ◽  
Justin R. Miller ◽  
Martha J. Larsen ◽  
Pamela J. Schultz ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell ◽  
Murine Fibroblasts ◽  
Dependent Cell

Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

2013 ◽  
Vol 11 (39) ◽  
pp. 6680 ◽  
Author(s):  
P. Vijaya Babu ◽  
Soumita Mukherjee ◽  
Girdhar Singh Deora ◽  
Keerthana Sarma Chennubhotla ◽  
Raghavender Medisetti ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Heck Reaction ◽  
Reaction Synthesis ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell ◽  
Intramolecular Heck Reaction
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