Distribution characteristics of cow’s milk-sIgE components in children with respiratory allergic diseases in southern China

Background: The distribution of allergens may vary with different geographic areas, suggesting the importance of local epidemiological data to support evidence-based prevention and management of allergic diseases. We investigated the distribution of common allergens in allergic patients in Guangzhou, southern China. Methods: 7,047 patients with allergic symptoms were examined for serum sIgE to 15 common allergens in thisregion, based on the protocol of reversed enzyme allergosorbent test. Results: 4,869 (69.09%) of the subjects tested positive for sIgE to at least one of the 15 common allergens. There was no statistical difference in the overall rate of positive sIgE detection between males (3128/4523, 69.16%) and females (1741/2524, 68.98%). Der pteronyssinus and Der farinae were the most common aeroallergens, while eggs and cow’s milk the most common food allergens, responsible for higher positive rates of sIgE responses. A good correlation in positive sIgE response was found between Der pteronyssinus and Der farinae. By age-group analysis, we noted several peaks of sensitization to certain allergens: Der pteronyssinus, Der farinae, and Blomiatropicalis at age between 9 and 12; Blattellagermanica and mosquito at age between 15 and 18, cow’s milk before age 3; eggs and flour at age between 3 and 6; crabs and shrimps at age between 12 and 15. Along with older age, there was an ascending tendency in the overall positive rate of sIgE response to house dust mites among subjects who tested positive for sIgE to eggs or cow’s milk. Conclusions: Der pteronyssinus, Der farinae, cow’s milk, and eggs are major allergens in Guangzhou. Sensitization to eggs and cow’s milk is more common at younger age, and then gives place to the increasing prevalence of sensitization to Der pteronyssinus and Der farinae at older age. Such a sequence of events may be a result of allergy march. Knowledge on the prevalence of allergen sensitization in different age groups would help early diagnosis and intervention of allergic diseases in this large geographical region.

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Direct Inhibition of the Allergic Effector Response by Raw Cow’s Milk—An Extensive In Vitro Assessment

Cells ◽

10.3390/cells9051258 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1258

Author(s):

Suzanne Abbring ◽

Bart R. J. Blokhuis ◽

Julie L. Miltenburg ◽

Kiri G. J. Romano Olmedo ◽

Johan Garssen ◽

...

Keyword(s):

Mast Cell ◽

Mast Cells ◽

Cell Activation ◽

Allergic Diseases ◽

Raw Milk ◽

Mast Cell Activation ◽

Cow’S Milk ◽

Cow's Milk ◽

Ige Mediated ◽

Raw Cow’S Milk

The mechanisms underlying the allergy-protective effects of raw cow’s milk are poorly understood. The current focus is mainly on the modulation of T cell responses. In the present study, we investigated whether raw cow’s milk can also directly inhibit mast cells, the key effector cells in IgE-mediated allergic responses. Primary murine bone marrow-derived mast cells (BMMC) and peritoneal mast cells (PMC), were incubated with raw milk, heated raw milk, or shop milk, prior to IgE-mediated activation. The effects on mast cell activation and underlying signaling events were assessed. Raw milk was furthermore fractionated based on molecular size and obtained fractions were tested for their capacity to reduce IgE-mediated mast cell activation. Coincubation of BMMC and PMC with raw milk prior to activation reduced β-hexosaminidase release and IL-6 and IL-13 production, while heated raw milk or shop milk had no effect. The reduced mast cell activation coincided with a reduced intracellular calcium influx. In addition, SYK and ERK phosphorylation levels, both downstream signaling events of the FcεRI, were lower in raw milk-treated BMMC compared to control BMMC, although differences did not reach full significance. Raw milk-treated BMMC furthermore retained membrane-bound IgE expression after allergen stimulation. Raw milk fractionation showed that the heat-sensitive raw milk components responsible for the reduced mast cell activation are likely to have a molecular weight of > 37 kDa. The present study demonstrates that raw cow’s milk can also directly affect mast cell activation. These results extend the current knowledge on mechanisms via which raw cow’s milk prevents allergic diseases, which is crucial for the development of new, microbiologically safe, nutritional strategies to reduce allergic diseases.

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Feeding Infants with Cow’S Milk and Soy Allergy: Social and Economic Aspects of Efficacy

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/prolas-2013-0060 ◽

2013 ◽

Vol 67 (4-5) ◽

pp. 320-323

Author(s):

Irēna Putniòa ◽

Silvija Remberga ◽

Ingrîda Rumba-Rozenfelde

Keyword(s):

Milk Protein ◽

Allergic Diseases ◽

Cow’S Milk ◽

Substantial Part ◽

Small Children ◽

Cow's Milk ◽

Dietary Prevention ◽

Energy Needs ◽

Compensation Mechanisms ◽

Therapy Treatment

Abstract Allergy to cow’s milk protein and/or soy is common among allergic diseases in infants. They appear at an early infant stage and remain important in clinical practice from one up to three years. According to clinical research, cow’s milk allergy affects about 1.9-4.9% of babies and infants, respectively, and in addition some of them also suffer from soy protein allergy. Dietary prevention of allergic protein by its elimination in food is a significant part of treatment, and allows adequate development of babies and restricts the risk of progressive allergic diseases. Securing exclusive breastfeeding is one of the basic principles in successful therapy treatment. However, there are cases when breastfeeding does not prevent the development of cross milk protein allergy. Only adequate special feeding formulas can provide both energy needs and sufficient quantity of proteins (8.9-11.5%) in food when breastfeeding is not possible. Knowledge of effective compensation mechanisms become apparent by analysing the situation in Europe and USA in the area of different available feeding formulas using both the medical insurance system and randomised formula providing tolerance of the mixture at about 90-95%. The goal of research was to determine the correlation between the availability of a special mixture, parental adherence and treatment outcomes. Applying special formulas is a routine part of treatment, and there is no doubt about its efficacy. No compensation mechanisms exist in present-day Latvia, and the current complicated economic situation in Latvia reduces the ability of parents to choose and buy appropriate formula food. Therefore, a substantial part of therapy treatment is unavailable to infants. Dietary prevention of allergic diseases in infants and small children in Latvia needs special consideration also because of poor knowledge of parents regarding the real situation.

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FOOD ANAPHYLAXIS IN CHILDREN: RETROSPECTIVE ANALYSIS OF 53 CASES

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja607 ◽

2013 ◽

Vol 10 (5) ◽

pp. 22-26

Author(s):

N V Esakova ◽

A N Pampura

Keyword(s):

Retrospective Analysis ◽

Russian Federation ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Natural Course ◽

Cow’S Milk ◽

Topical Issue ◽

Common Cause ◽

Cow's Milk ◽

Food Anaphylaxis

Introduction. There are no studies on anaphylaxis in children in Russian Federation therefore this problem is a topical issue. Background. To determine the etiology, natural course of food anaphylaxis in Russian Federation children, to analyse the therapeutic care of anaphylaxis. Methods. 53 patients with food anaphylaxis were included in the study. All patients completed a questionnaire included questions about the triggers, clinical manifestations and treatment of anaphylaxis. Results. In 94% episodes of anaphylactic reactions occurred at home, 2/3 (66%) of patients had two or more episodes of food anaphylaxis before, 5 (8%) infants didn’t have allergic diseases, 23 patients (43%) had anaphylactic reactions to more than one product. Cow’s milk (43%) was the most common cause of anaphylaxis. Cow’s milk caused anaphylaxis in 67% of children under 2 years (p

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Atypical Food protein-induced enterocolitis syndrome in children: Is IgE sensitization an issue longitudinally?

Allergologia et Immunopathologia ◽

10.15586/aei.v49i3.79 ◽

2021 ◽

Vol 49 (3) ◽

pp. 73-82

Author(s):

Athina Papadopoulou ◽

Theano Lagousi ◽

Elpiniki Hatzopoulou ◽

Paraskevi Korovessi ◽

Stavroula Kostaridou ◽

...

Keyword(s):

Immunoglobulin E ◽

Allergic Diseases ◽

Cow’S Milk ◽

Food Protein ◽

Cow's Milk ◽

T Helper 2 ◽

Term Evaluation ◽

Ige Mediated ◽

Trigger Mechanisms

Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is a clinically well-characterised, non-Immunoglobulin E (IgE)-mediated food allergy syndrome, yet its rare atypical presen-tation remains poorly understood.Objective: Aim of this study was to present the 10-year experience of a referral centre high-lighting the atypical FPIES cases and their long-term outcome.Methods: FPIES cases were prospectively evaluated longitudinally in respect of food outgrowth and developing other allergic diseases with or without concomitant IgE sensitisation.Results: One hundred subjects out of a total of 14,188 referrals (0.7%) were identified. At pre-sentation, 15 patients were found sensitised to the offending food. Fish was the most frequent eliciting food, followed by cow’s milk and egg. Tolerance acquisition was earlier for cow’s milk, followed by egg and fish, while found not to be protracted in atypical cases. Resolution was not achieved in half of the fish subjects during the 10-year follow-up time. Sensitisation to food was not related to infantile eczema or culprit food, but was related to sensitisation to aeroallergens. In the long-term evaluation, persistence of the FPIES or aeroallergen sensitisation was significantly associated with an increased hazard risk of developing early asthma symptoms. Conclusion: Sensitisation to food was related neither to eczema or culprit food nor to tolerance acquisition but rather to the development of allergic asthma through aeroallergen sen-sitisation. In addition to an IgE profile at an early age, FPIES persistence may also trigger mechanisms switching FPIES cases to a T-helper 2 cells immune response later in life, predis-posing to atopic respiratory symptoms; albeit further research is required.

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Sensitizing characteristics of cow’s milk and major components in young children with allergic diseases in Guangdong Province

10.26226/morressier.5b0a29cdd4cd1a00196f77fa ◽

2018 ◽

Author(s):

Huimin Huang

Keyword(s):

Young Children ◽

Guangdong Province ◽

Allergic Diseases ◽

Cow’S Milk ◽

Cow's Milk

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ANTIGEN-INDUCED LYMPHOBLAST TRANSFORMATION IN THE DIAGNOSIS OF COW'S MILK ALLERGIC DISEASES IN INFANCY AND EARLY CHILDHOOD

Allergy ◽

10.1111/j.1398-9995.1974.tb02694.x ◽

1974 ◽

Vol 30 (1) ◽

pp. 34-42 ◽

Cited By ~ 8

Author(s):

L. ENDRE ◽

P. OSVÁTH

Keyword(s):

Early Childhood ◽

Allergic Diseases ◽

Cow’S Milk ◽

Cow's Milk ◽

Infancy And Early Childhood

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A CASE OF THE EARLY DEVELOPMENT OF ATOPIC DERMATITIS IN A NURSING INFANT

Вопросы современной педиатрии ◽

10.15690/vsp.v17i3.1894 ◽

2018 ◽

Vol 17 (3) ◽

pp. 244-249

Author(s):

Tatiana V. Turti ◽

Ekaterinа G. Bokuchava ◽

Alexey S. Illarionov ◽

Anastasiya G. Selivanova

Keyword(s):

Atopic Dermatitis ◽

Secondary Prevention ◽

Allergic Diseases ◽

Perinatal Period ◽

Cow’S Milk ◽

Severe Atopic Dermatitis ◽

Breastfeeding Initiation ◽

Cow's Milk ◽

Atopic Status ◽

Antibody Titres

Background. The early (in the first months of life) formation of atopic status and the development of allergies are not uncommon pathological conditions in a pediatrician's practice, requiring sufficiently studied and theoretically grounded measures for the organization of primary/secondary prevention.Case Report. The parents visited a doctor with complaints of widespread skin rashes and troubled night sleep in a child from the age of two months. A burdened history of allergies of the child was traced through the female lineage (food allergy in the mother, maternal sister and grandmother). The perinatal period is complicated by acute respiratory infection in the third trimester and by maternal nutritional preferences (consumption of goat's and whole cow's milk). The delayed (on the 5th day of life) breastfeeding initiation, feeding with cow's milk-based formula, living next to an industrial enterprise, maternal choices of products with a high sensitizing potential not only during pregnancy but also during breastfeeding probably caused the early formation of atopic status — dry skin, widespread papular rash, microvesicles on the cheeks, hips, shins, scratching traces, serous-bloody crusts objectively defined at admission. The SCORAD scores corresponded to severe atopic dermatitis. The ImmunoCAP technology revealed high antibody titres to a number of products, including cow's milk and chicken egg proteins. Based on the findings, a therapeutic diet aimed at secondary prevention of allergic diseases, including respiratory allergies, was developed for the child.Conclusion. A case of the early (from 2 months) formation of atopic status with the development of atopic dermatitis caused by polyvalent food sensitization is described. A therapeutic diet containing products with a low sensitizing potential was prescribed for the child. The suggested therapy including the diet should prevent the progression of an allergic disease.

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A History of Cow’s Milk Allergy Is Associated with Lower Vitamin D Status in Schoolchildren

Hormone Research in Paediatrics ◽

10.1159/000478779 ◽

2017 ◽

Vol 88 (3-4) ◽

pp. 244-250 ◽

Cited By ~ 5

Author(s):

Jenni Rosendahl ◽

Mikael Fogelholm ◽

Anna Pelkonen ◽

Mika J. Mäkelä ◽

Outi Mäkitie ◽

...

Keyword(s):

Vitamin D ◽

Allergic Diseases ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Cow’S Milk ◽

Milk Allergy ◽

Vitamin D Status ◽

Cow's Milk ◽

History Of ◽

Lower Vitamin

Background/Aims: Vitamin D insufficiency is common in children. We aimed to evaluate the main determinants of vitamin D status in Finnish school-aged children, including the history of allergic diseases. Methods: We conducted a cross-sectional study on 171 ten-year-olds where serum 25-hydroxyvitamin D (25[OH]D) levels were measured, and data on food consumption and use of vitamin D supplements were collected. The history of allergic diseases was evaluated with a validated questionnaire. Results: Vitamin D insufficiency (<50 nmol/L) was observed in 16% of the children. In children with a history of cow’s milk allergy, the mean 25(OH)D levels were lower than in children without allergy (60.5 ± 12.6 nmol/L vs. 75.5 ± 22.3 nmol/L, p = 0.004). Lack of vitamin D supplementation, female gender, non-Caucasian ethnicity, and a history of milk allergy were associated with lower vitamin D status. Conclusion: The vitamin D status in our study sample of Finnish schoolchildren was sufficient, which suggests that health policy strategies – such as the recommendation of vitamin D supplementation and the fortification of food products with vitamin D – have been successful in improving vitamin D status in children. Special concern should be given to children with a history of milk allergy to ensure their vitamin D sufficiency.

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