The Importance of Hail Events for Landslides and Bedload Transport in Austrian Alpine Torrents

Landslides and bedload transport can be a threat to people, infrastructure, and vegetation. Many detailed hydrometeorological trigger mechanisms of such natural hazards are still poorly understood. This is in particular valid concerning hail as a trigger of these processes. Therefore, this study aims to determine the influence of hail on landslides and bedload transport in alpine torrents. Based on a generated table from an event register of mountain processes maintained by the Avalanche and Torrent Control Unit (WLV) and weather data provided by the Centre for Meteorology and Geodynamics (ZAMG), 1,573 observed events between 1980 and 2019 in 79 Austrian alpine sites are analysed. Thiessen polygons are used to regionalise local weather data to adjacent regions. The spatial extend of these regions are merged with the registered torrential events. As a result of a stepwise filtering of the used data, the final inventory was created.The results show that 95.1% of the investigated torrential processes triggered by hailstorms are debris flows or debris flow-like transports. Within the study period, a peak of hail-triggered landslides and bedload transport can be recognised in the first 10 days of August in all 39 years. Furthermore, the results suggest that hail is rather a direct than an indirect trigger for landslides and bedload transport.Overall, we conclude that the influence of hail on landslides and bedload transport is significant. Respective hydrometeorological triggering conditions should be included in any regions. Further research for this topic is required to explore the process dynamics in greater detail.

The Power of Social Attribution: Perspectives on the Healing Efficacy of Ayahuasca

During the last decades, ayahuasca gained much popularity among non-Indigenous and out-of-Amazonia based populations. In popular culture, it has been advertised as a natural remedy that was discovered by Indigenous peoples ante millennia and that has been used for shamanic healing of all kinds of ailments. This “neo-shamanic,” and often recreational, use of ayahuasca, however, has to be distinguished from traditional Indigenous praxes on the one hand, and, on the other hand, from medical investigation in the modern world. The former, Indigenous use mainly understands ayahuasca as an amplifying power for interacting with non-human beings in the animal, plant, or spirit realms. Within this paradigm, efficacy is not dependent on the drug, but on the correct communication between the healer (or sorcerer) and the non-human powers that are considered real and powerful also without resorting to ayahuasca. The latter, modern mode of understanding, contrastingly treats the neurochemical processes of MAO inhibition and dimethyltryptamine activity as trigger mechanisms for a series of psychological as well as somatic responses, including positive outcomes in the treatment of various mental conditions. I argue that there is an ontological incommensurability occurring especially between the Indigenous and medicinal concepts of ayahuasca use (with recreational use in its widest understanding trying to make sense from both sides). Modern medical applications of ayahuasca are so fundamentally different from Indigenous concepts that the latter cannot be used to legitimate or confirm the former (and vice versa). Finally, the deep coloniality in the process of appropriation of the Indigenous by the modern has to be questioned and resolved in any case of ayahuasca application.

The effect of modal properties of crash box structures with trigger mechanisms towards the crashworthiness by using finite element analysis

In the automotive structure, there are different components that utilise aluminium alloy (AA) sheets and it is used widely in the car body-in-white which comprise bumpers and the crash box structure at the front end of the car which specifically designed to withstand the event of collision. As the structures are also experiencing dynamic loading, it were also a concern for the structures to show satisfied modal properties. In this study, the modal properties of the crash box structures are investigated along with the effect of the modal properties towards the crashworthiness behaviour of the structure itself with the approach of finite element analysis. Experimental modal analysis was also done to further validating the finite element analysis of the modal properties. Three different designs of trigger mechanisms are applied towards the crash box structure to observe on both findings. For the connector element, equivalent nodes of both parts of the crash box structures are used. For the results, the correlation from both findings did show that the presence of trigger mechanism did decreased the magnitude of natural frequencies as well as the mode shape as shown by crash box type 3 by 9.50% and for the crashworthiness output, the crashworthiness behaviour of the crash box with trigger mechanisms were better in term of the collisions phases indicated by the primary peak force and the secondary peak force from the force-displacement curve as also shown by crash box structure type 3 with the percentage of 22.59%. The study does shows that the stiffness and mass distribution due to the presence of trigger mechanism do affect the modal properties of a structure as well as its crashworthiness output.

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Introduction Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence shows that active digestive enzymes can leak out of the small intestine into the systemic circulation and cause cell dysfunctions and organ failure. Methods Accordingly, we investigated in morning fasting plasma of heart failure (HF) patients the presence of pancreatic trypsin, a major enzyme responsible for digestion. Results Western analysis shows that trypsin in plasma is significantly elevated in HF compared to matched controls and their concentrations correlate with the cardiac dysfunction biomarker BNP and inflammatory biomarkers CRP and TNF-α. The plasma trypsin levels in HF are accompanied by elevated pancreatic lipase concentrations. The trypsin has a significantly elevated activity as determined by substrate cleavage. Mass spectrometry shows that the number of plasma proteins in the HF patients is similar to controls while the number of peptides was increased about 20% in HF patients. The peptides are derived from extracellular and intracellular protein sources and exhibit cleavage sites by trypsin as well as other degrading proteases (data are available via ProteomeXchange with identifier PXD026332). Connclusions These results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients. Conclusions These results provide the first evidence that active digestive enzymes leak into the systemic circulation and may participate in myocardial cell dysfunctions and tissue destruction in HF patients.

Are communities of practice a way to support health literacy: a study protocol for a realist review

IntroductionCommunities of practice are used for knowledge sharing and learning in health settings. However, more needs to be known to understand how they work, if they work different in different settings and what outcomes they might generate. Of particular interest is their potential role in health literacy development.Methods and analysisThis realist review will be undertaken in seven stages, aiming to develop a framework to show how the various contexts of communities of practice in health settings trigger mechanisms that lead to improved health literacy outcomes. The first stage of a realist review is considered important as it clarifies the scope of the review, yet it is rarely elaborated in detail. This paper describes this first stage in detail and shows how scoping techniques can support drafting an initial framework which can guide the rest of the review. After the initial scoping review, the subsequent stages follow an iterative and recurring process (until saturation is reached) that includes searching and appraising evidence, extracting and organising results, and analysing and summarising. The review will then generate conclusions and recommendations for stakeholders seeking to use communities of practice for their health literacy challenges. Findings of the scoping review are presented in this paper as part of the methods description to show the relevance of conducting a scoping review prior to a realist review.Ethics and disseminationEthical review is not required for this review. Experts and stakeholders will be involved in the process after the first stage to increase the quality of the process and to ensure practical relevance and uptake. This review focuses on communities of practice and health literacy, yet findings will likely be relevant for other health settings. Findings will be disseminated through stakeholders, publications, presentations and formal and informal reports.

Atypical Food protein-induced enterocolitis syndrome in children: Is IgE sensitization an issue longitudinally?

Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is a clinically well-characterised, non-Immunoglobulin E (IgE)-mediated food allergy syndrome, yet its rare atypical presen-tation remains poorly understood.Objective: Aim of this study was to present the 10-year experience of a referral centre high-lighting the atypical FPIES cases and their long-term outcome.Methods: FPIES cases were prospectively evaluated longitudinally in respect of food outgrowth and developing other allergic diseases with or without concomitant IgE sensitisation.Results: One hundred subjects out of a total of 14,188 referrals (0.7%) were identified. At pre-sentation, 15 patients were found sensitised to the offending food. Fish was the most frequent eliciting food, followed by cow’s milk and egg. Tolerance acquisition was earlier for cow’s milk, followed by egg and fish, while found not to be protracted in atypical cases. Resolution was not achieved in half of the fish subjects during the 10-year follow-up time. Sensitisation to food was not related to infantile eczema or culprit food, but was related to sensitisation to aeroallergens. In the long-term evaluation, persistence of the FPIES or aeroallergen sensitisation was significantly associated with an increased hazard risk of developing early asthma symptoms. Conclusion: Sensitisation to food was related neither to eczema or culprit food nor to tolerance acquisition but rather to the development of allergic asthma through aeroallergen sen-sitisation. In addition to an IgE profile at an early age, FPIES persistence may also trigger mechanisms switching FPIES cases to a T-helper 2 cells immune response later in life, predis-posing to atopic respiratory symptoms; albeit further research is required.

Consideration of Trigger Mechanisms of Natural and Man-made Disasters in the Earth’s Geospheres

Have been presented the trigger mechanisms of accidents emergence in different Earth's Geospheres. Has been given the definition for the trigger mechanism of initiation of changes in geosystems. The threshold value for the starting (initiating) trigger signal has been detailed. The graphic representation of work of a trigger system has been presented, and its functioning has been explained. Various ways for switching of a trigger system have been revealed. The principles of the trigger impact on the troposphere, the lower part of the Earth's atmosphere, initiation of cyclones and earthquakes, and descent of avalanches and glacial mudflows have been detailed.