scholarly journals Determination of 11 minerals in children using inductively coupled plasma mass spectrometry

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaofeng Li ◽  
Chunnan Wang ◽  
Yang Wang ◽  
Xusheng Zhao ◽  
Na Li
Keyword(s):  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Reference Intervals ◽  
Liaoning Province ◽  
Healthy Children ◽  
Inductively Coupled ◽  
Age Related ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Laboratory Examinations

Abstract Background Minerals play an important role in children’s growth and cognition. In this study, our aim was to establish reference intervals of mineral level in Children of Liaoning province (China) and provide a reliable basis for future preventive healthcare guidelines. Methods Random samples of 2217 healthy children aged 0–15 years who were referred for routine hospital laboratory examinations in the cities of Shenyang, Fushun, Fuxin, Benxi, Chaoyang and Lingyuan were invited to participate in the study. Serum levels of Calcium (Ca), Iron (Fe), Zinc (Zn), Magnesium (Mg), Copper (Cu), Manganese (Mn), Selenium (Se), Mercury (Hg), Nickel (Ni), Cobalt (Co), and Lithium (Li) were determined by inductively coupled plasma mass spectrometer(ICP-MS). Results Sex-related significant differences in the serum concentrations of the Mg and Cu (P < 0.05). Age-related significant differences were found in serum levels of Ca, Fe, Zn, Mg, Cu and Mn (P < 0.05) and the concentrations of 9 minerals (Ca, Mg, Cu, Mn,Se,Hg,Ni,Co and Li in serum varied from season to season (P < 0.05). The Spearman correlation matrix of 11 minerals was shown as a heat map, the correlations between Ca-Zn, Ca-Mg, Fe-Zn, Fe-Se, Mn-Ni, Se-Hg, Se-Ni, Hg-Ni, and Ni-Co, Ni-Li were the strongest compared with others. Conclusions The reference intervals of serum 11 minerals for children should considering the sex, age and season, which may be useful for decisive diagnoses of abnormality of the 11minerals and the related diseases.

scholarly journals Analysis of eight nutrient elements in peripheral blood of children and adolescents using inductively coupled plasma‐mass spectrometry

2021 ◽  
Author(s):  
Fang Luan ◽  
Bin Liu ◽  
Shuzhen Sun ◽  
Yuan Chen ◽  
Yanqiu Xu ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Whole Blood ◽  
Inductively Coupled Plasma ◽  
Age Groups ◽  
Reference Intervals ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
And Gender

Abstract Background Several researches have been conducted on the associations between elements and diseases. Few studies have examined trace elements in young people’s hair. The objective of this study is to investigate the influence of age, gender and season on the contents of magnesium (Mg), calcium (Ca), Iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), selenium (Se) and strontium (Sr) as well as to establish the reference intervals (RIs). Methods We conducted a retrospective study of 589 apparently healthy children and adolescents under 19 years old. Quantitative analysis has been carried out using inductively coupled plasma-mass spectrometry (ICP-MS). Eight nutrient elements in peripheral blood of children and adolescents in eastern China were grouped according to age, sex or season, and analyzed using and Mann-Whitney U test and spearman statistical analyses. RIs were defined by using 95% confidence interval. Results Precisions of ICP-MS detecting for Mg, Ca, Fe, Cu, Zn, Mn, Se and Sr are 2.8%~12.2%. The linearity were all > 0.999 and the bias were all within 10%. Differences between contents of particularly Mg, Fe, Cu and Zn in girls’ and boys’ whole blood were found, and higher contents of Mg, Cu for boys were measured in some age groups. Positive correlations for Fe, Zn, Se and Sr, while negative for Ca and Cu were found with age. And substantial differences between age groups were stated. In general, an increasing trend was found for bioelements (Fe, Zn,Se) both for girls and boys in all age groups, while for Ca and Cu changes were even decreasing for children and teenagers. The most frequently correlating element pairs were Fe-Zn, Mg-Se, and Fe-Se in five successive age groups. Lower contents of essential elements (Mg, Ca, Fe, Zn, Se) were found in summer comparing with other seasons. Finally, the reference interval of each element was initially established according to age and gender grouping. Conclusions The contents of elements in whole blood varies depending mainly on the gender and age of children and adolescents. Besides, season is also a factor that affects the contents of elements in the body. The reference intervals of elements in whole blood grouped by age and gender provide a reference basis for clinical diagnosis and treatment of element-related diseases.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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