scholarly journals Topical tranexamic acid in elderly patients with femoral neck fractures treated with hemiarthroplasty: efficacy and safety? - a case-control study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Dae-Kyung Kwak ◽  
Chul-Young Jang ◽  
Dae-Hwan Kim ◽  
Sang-Hyun Rhyu ◽  
Ji-Hyo Hwang ◽  
...  
2019 ◽  
Vol 8 (4) ◽  
pp. 306-311 ◽  
Author(s):  
Preeti Shashi ◽  
Dharmesh Gopalakrishnan ◽  
Malav P Parikh ◽  
Bo Shen ◽  
Gursimran Kochhar

Abstract Background Vedolizumab was demonstrated to be safe and effective in adults with moderately to severely active inflammatory bowel disease (IBD) in clinical trials. However, there are limited data regarding its efficacy and safety in elderly patients. Methods This was a case–control study comparing the efficacy (measured by rates of mucosal healing and need for IBD surgery) and safety of vedolizumab in IBD among patients ≥65 years of age (the elderly group) vs those <65 years (the control group). The two groups were matched individually on a 1:4 ratio based on gender and type of IBD. Conditional logistic regression was used for stratified analysis to calculate odds ratios and confidence intervals. Results We included 25 IBD patients in the elderly group and 100 matched patients in the comparison group. Eighty patients had Crohn’s disease and 45 had ulcerative colitis. At baseline, the groups were comparable with regard to duration of IBD, prior anti-TNF therapy, and prior IBD surgery. The rate of mucosal healing on follow-up endoscopy was comparable between the elderly and control groups (50% vs 53%, P = 0.507). Although more patients in the elderly group required IBD-related surgery while on vedolizumab, the difference did not reach statistical significance (40% vs 19%, P = 0.282). Rates of vedolizumab-related adverse effects—rash, arthralgia, infections, infusion reactions, and dyspnea—were comparable between the two groups (all P > 0.05). Conclusions In a real-world setting, vedolizumab was demonstrated to have an efficacy and safety profile among elderly IBD patients that were comparable to younger controls.


2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Mirella López Picazo ◽  
Ludovic Humbert ◽  
Renaud Winzenrieth ◽  
Silvana Di Gregorio ◽  
Miguel A. González Ballester ◽  
...  

2019 ◽  
Vol 10 ◽  
pp. 215145931982747 ◽  
Author(s):  
Christopher H. Rashidifard ◽  
Nicholas Romeo ◽  
Mark Richardson ◽  
Paul Muccino ◽  
Thomas DiPasquale ◽  
...  

Introduction: This case–control study evaluates the success of indwelling pain catheters in nonoperatively treated femoral neck fractures (FNFs) for end-of-life pain management. Methods: Patients older than 65 years with nonoperatively treated FNFs were retrospectively identified at a level 1 trauma center between March 2012 and September 2015. Twenty-three received indwelling continuous peripheral pain catheters (experimental) and 10 received traditional pain control modalities (control). Pain scores 24 hours before/after pain management interventions, ambulation status at admission and discharge, mortality at 30 days/1 year, and length of hospital stay (LOS) were compared between treatment groups. Results: The experimental and control groups were similar with respect to demographics, differing only in pre-fracture ambulatory status ( P = .03). The 30-day mortality was 52% versus 50% (odds ratio, OR: 1.1 [95% confidence interval, CI: 0.25-4.82], P = .99) and 1-year mortality was 87% versus 80% (OR: 1.67 [95% CI: 0.23-11.9], P = .63) for experimental and control groups, respectively. The LOS did not statistically significantly differ for experimental and control groups (5.3 ± 3.56 days vs 3.8 ± 1.81 days, P = .15), respectively. The experimental group experienced twice the improvement in ambulation status (1.0 ± 0.56 vs 0.5 ± 0.71, P = 0.03) and greater improvement in pain scores (4.5 ± 2.19 vs 1.2 ± 2.72, P = .002). Discussion: Operative management of FNFs may not be indicated in patients with advanced age and comorbidities. Regardless, these patients require pain palliation and early mobilization while minimizing hospital LOS and opiate consumption. Conclusion: This case–control study demonstrates significant improvement in both pain level and ambulatory status for patients treated with indwelling continuous peripheral catheters. Future studies should further evaluate with a larger sample size; however, this study provides an excellent launching point for palliative management of this complex population.


2018 ◽  
Vol 35 (1) ◽  
pp. 49-57
Author(s):  
Ivana Milićević ◽  
Slobodan Janković ◽  
Iva Grubor

Summary Delirium is a common complication in hospitalized elderly patients suffering from hip fractures. Considering the growing incidence of delirium, understanding the risk factors for this condition is of great importance. The preoperative prevalence of delirium is approximately 4.4–35.6%, while postoperative prevalence is even higher - 4–53.3%. Various studies have shown the multifactorial etiology of delirium arising from a combination of predisposing and precipitating factors. The aim of this study was to explore these factors, which can contribute to delirium in patients with femoral neck fractures. This case control study included 62 patients diagnosed with femoral neck fractures, with 31 cases and 31 controls. Results have shown that the use of sedatives, especially benzodiazepines, and smoking increase the risk of delirium by five and sixteen times, respectively.


Author(s):  
Nobuhiro Tsuchiya ◽  
Chikara Kunisaki ◽  
Sho Sato ◽  
Yusaku Tanaka ◽  
Kei Sato ◽  
...  

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