Sensorimotor performance in acute-subacute non-specific neck pain: a non-randomized prospective clinical trial with intervention

Abstract Background The assessment of cervical spine kinematic axial rotation performance is of great importance in the context of the study of neck sensorimotor control. However, studies addressing the influence of the level of provocation of spinal pain and the potential benefit of passive manual therapy mobilizations in patients with acute-subacute non-specific neck pain are lacking. Methods A non-randomized prospective clinical trial with an intervention design was conducted. We investigated: (1) the test-retest reliability of kinematic variables during a fast axial head rotation task standardized with the DidRen laser test device in 42 Healthy pain-free Control Participants (HCP) (24.3 years ±6.8); (2) the differences in kinematic variables between HCP and 38 patients with Acute-subacute Non-Specific neck Pain (ANSP) assigned to two different groups according to whether their pain was localized in the upper or lower spine (46.2 years ±16.3); and (3) the effect of passive manual therapy mobilizations on kinematic variables of the neck during fast axial head rotation. Results (1) Intra-class correlation coefficients ranged from moderate (0.57 (0.06-0.80)) to excellent (0.96 (0.91-0.98)). (2) Kinematic performance during fast axial rotations of the head was significantly altered in ANSP compared to HCP (age-adjusted) for one variable: the time between peaks of acceleration and deceleration (p<0.019). No significant difference was observed between ANSP with upper vs lower spinal pain localization. (3) After the intervention, there was a significant effect on several kinematic variables, e.g., ANSP improved peak speed (p<0.007) and performance of the DidRen laser test (p<0.001), with effect sizes ranging from small to medium. Conclusion (1) The DidRen laser test is reliable. (2) A significant reduction in time between acceleration and deceleration peaks was observed in ANSP compared to HCP, but with no significant effect of spinal pain location on kinematic variables was found. (3) We found that neck pain decreased after passive manual therapy mobilizations with improvements of several kinematic variables. Trial registration Registration Number: NCT 04407637

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The effect of manual therapy with augmentative exercises for neck pain: a randomised clinical trial

Journal of Manual & Manipulative Therapy ◽

10.1179/2042618615y.0000000011 ◽

2015 ◽

Vol 23 (5) ◽

pp. 264-275 ◽

Cited By ~ 3

Author(s):

Shannon Bravo Petersen ◽

Chad Cook ◽

Megan Donaldson ◽

Amy Hassen ◽

Alyson Ellis ◽

...

Keyword(s):

Clinical Trial ◽

Neck Pain ◽

Manual Therapy ◽

Randomised Clinical Trial

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Efficacy of manual therapy on psychological status and pain in patients with neck pain. A randomized clinical trial

Saudi Medical Journal ◽

10.15537/smj.2021.1.25589 ◽

2021 ◽

Vol 42 (1) ◽

pp. 82-90

Author(s):

Samar Alansari ◽

Enas Youssef ◽

Alsayed Shanb

Keyword(s):

Clinical Trial ◽

Neck Pain ◽

Randomized Clinical Trial ◽

Manual Therapy ◽

Psychological Status

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The Effect of Combination Therapy; Manual Therapy and Exercise, in Patients With Non-Specific Chronic Neck Pain: A Randomized Clinical Trial

Physical Treatments - Specific Physical Therapy ◽

10.32598/ptj.7.2.113 ◽

2017 ◽

pp. 113-121 ◽

Cited By ~ 2

Author(s):

Maryam Ghodrati ◽

Zahra Mosallanezhad ◽

Mohsen Shati ◽

Forouzan Rastgar Koutenaei ◽

Mohammad Reza Nourbakhsh ◽

...

Keyword(s):

Clinical Trial ◽

Combination Therapy ◽

Neck Pain ◽

Randomized Clinical Trial ◽

Manual Therapy ◽

Chronic Neck Pain ◽

Therapy Manual

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Effect of Combined Manual Therapy and Therapeutic Exercise Protocols on the Postural Stability of Patients with Non-Specific Chronic Neck Pain. A Secondary Analysis of Randomized Controlled Trial

Journal of Clinical Medicine ◽

10.3390/jcm11010084 ◽

2021 ◽

Vol 11 (1) ◽

pp. 84

Author(s):

Carlos Bernal-Utrera ◽

Ernesto Anarte-Lazo ◽

Juan Jose Gonzalez-Gerez ◽

Manuel Saavedra-Hernandez ◽

Elena De-La-Barrera-Aranda ◽

...

Keyword(s):

Clinical Trial ◽

Neck Pain ◽

Manual Therapy ◽

Postural Stability ◽

Chronic Neck Pain ◽

Control Group ◽

Placebo Control ◽

Therapeutic Exercise ◽

The Relationship

Postural stability is a little-studied factor in non-specific chronic neck pain; the causes that can alter it are unknown. The relationship with chronic pain could be a determining factor for its deficit. The aim of this study was to investigate the relationship between sustained pain and a postural stability deficit. A randomized and blinded clinical trial (double-blind; placebo control; 12 weeks follow-up) was conducted with a total of 69 subjects divided into three groups, two experimental (manual therapy and specific exercise) and a control treatment, and carried out over a treatment period of three weeks with a follow-up after 12 weeks. Their postural stability was assessed through the overall balance index (OBI). The postural stability of subjects with non-specific chronic neck pain improved in the experimental treatments. There were no statistically significant differences between the experimental groups. This trial found that manual therapy and therapeutic exercise significantly improved OBI compared to the control group. Trial registration: Brazilian Clinical Trial Registry, RBR-2vj7sw.

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Comparison of immediate effects of sling-based manual therapy on specific spine levels in subjects with neck pain and forward head posture: a randomized clinical trial

Disability and Rehabilitation ◽

10.1080/09638288.2019.1571638 ◽

2019 ◽

Vol 42 (19) ◽

pp. 2735-2742 ◽

Cited By ~ 3

Author(s):

Dae-Hyun Kim ◽

Suhn-Yeop Kim

Keyword(s):

Clinical Trial ◽

Neck Pain ◽

Randomized Clinical Trial ◽

Manual Therapy ◽

Forward Head Posture ◽

Head Posture

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Failure Rates of Orthodontic Fixed Lingual Retainers bonded with Two Flowable Light-cured Adhesives: A Comparative Prospective Clinical Trial

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1902 ◽

2016 ◽

Vol 17 (8) ◽

pp. 630-634 ◽

Cited By ~ 1

Author(s):

Nabeel F Talic

Keyword(s):

Clinical Trial ◽

Odds Ratio ◽

Prospective Clinical Trial ◽

Failure Rates ◽

Survival Times ◽

Prospective Randomized Clinical Trial ◽

Low Viscosity ◽

Significant Difference ◽

Flowable Composites

ABSTRACT Introduction This comparative prospective randomized clinical trial examined the in vivo failure rates of fixed mandibular and maxillary lingual retainers bonded with two light-cured flowable composites over 6 months. Materials and methods Consecutive patients were divided into two groups on a 1:1 basis. Two hundred fixed lingual retainers were included, and their failures were followed for 6 months. One group (n = 50) received retainers bonded with a nano-hybrid composite based on nano-optimized technology (Tetric-N-Flow, Ivoclar Vivadent). Another group (n = 50) received retainers bonded with a low viscosity (LV) composite (Transbond Supreme LV, 3M Unitek). Results There was no significant difference between the overall failure rates of mandibular retainers bonded with Transbond (8%) and those bonded with Tetric-N-Flow (18%). However, the odds ratio for failure using Tetric-N-flow was 2.52-fold greater than that of Transbond. The failure rate of maxillary retainers bonded with Transbond was higher (14%), but not significantly different, than that of maxillary retainers bonded with Tetric- N-flow (10%). There was no significant difference in the estimated mean survival times of the maxillary and mandibular retainers bonded with the two composites. Conclusion Both types of composites tested in the current study can be used to bond fixed maxillary and mandibular lingual retainers, with low failure rates. How to cite this article Talic NF. Failure Rates of Orthodontic Fixed Lingual Retainers bonded with Two Flowable Light-cured Adhesives: A Comparative Prospective Clinical Trial. J Contemp Dent Pract 2016;17(8):630-634.

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Effect of THAM upon outcome in severe head injury: a randomized prospective clinical trial

Journal of Neurosurgery ◽

10.3171/jns.1993.78.1.0054 ◽

1993 ◽

Vol 78 (1) ◽

pp. 54-59 ◽

Cited By ~ 94

Author(s):

Aizik L. Wolf ◽

Lion Levi ◽

Anthony Marmarou ◽

John D. Ward ◽

Paul J. Muizelaar ◽

...

Keyword(s):

Clinical Trial ◽

Head Injury ◽

Adverse Effects ◽

Glasgow Coma Scale ◽

Severe Head Injury ◽

Prospective Clinical Trial ◽

Content Type ◽

Coma Scale ◽

Significant Difference ◽

Fine Print

✓ Although mortality and morbidity rates from head injury have been reduced substantially by improved prehospital interventions, intensive care, and aggressive management of intracranial pressure (ICP), successful treatment of the primary brain injury has been elusive. In experimental models, tromethamine (THAM) has been effective in treating head injury; this drug acts by entering the cerebrospinal fluid compartment, reducing cerebral acidosis and ICP, and reversing the adverse effects of prophylactic hyperventilation on early recovery. In this randomized prospective clinical trial, THAM was studied to determine if it had beneficial effects in the early management of severe head injuries and if the adverse effects of hyperventilation could be prevented. A total of 149 patients with severe head injury (Glasgow Coma Scale scores of ≤ 8) were randomly assigned to either a control or a THAM group. Both groups of patients matched in terms of clinical parameters, including age, sex, number of surgical mass lesions, number in each Glasgow Coma Scale stratum, and first ICP measurement. All patients were treated by a standard management protocol, intubated, mechanically ventilated, and maintained in the pCO2 range of 32 to 35 mm Hg for 5 days. Tromethamine was administered as a 0.3-M solution in an initial loading dose (body weight × blood acidity deficit, average 4.27 cc/kg/hr) given over 2 hours, followed by a constant infusion of 1 ml/kg/hr for 5 days. Outcome was measured at 3, 6, and 12 months postinjury. Although analysis indicated no significant difference in outcome between these two groups at 3 months, 6 months, and 1 year, there was a difference regarding ICP. The time that ICP was above 20 mm Hg in the first 48 hours postinjury was less in patients treated with THAM (p < 0.05). Also, the number of patients requiring barbiturate coma was significantly less in the THAM group (5.48% vs. 18.4%, p < 0.05). The authors conclude that THAM ameliorates the deleterious effect of prolonged hyperventilation, may be beneficial in ICP control, and warrants further study as to the dosage and timing of administration.

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