Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001–2010

There is still limited data on the association between 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone health in healthy younger adults, particularly in Latin America. This cross-sectional analysis aimed to investigate the associations of 25(OH)D and plasma PTH concentrations with bone parameters, and potential confounders, in women living in a high (England) or low (Brazil) latitude country. Bone was assessed by either peripheral quantitative computed tomography (pQCT) (England) or dual-energy x-ray absorptiometry (DXA) scan (Brazil), serum 25(OH)D concentrations by high performance liquid chromatography tandem mass spectrometry (HPLC-MS) and PTH by the chemiluminescent method. In participants living in England, total volumetric bone mineral density (vBMD) was significantly higher in women <29 years compared to ≥30 years, and total and cortical vBMD values at the 66% site were negatively correlated with weight and body mass index (BMI). In participants living in Brazil, age was positively correlated with bone mineral density (BMD) at the femur and bone mineral content (BMC), and weight, BMI, and body fat were correlated with BMD (lumbar spine and femur) and BMC. PTH concentrations were negatively correlated with 25(OH)D concentrations, and the prevalence of secondary hyperparathyroidism was 28.6% (n = 14) in participants with concentrations <25 nmol/L and 12.2% (n = 41) with concentrations between 25 and 49.9 nmol/L, compared to 6.3% (n = 79) in those with concentrations ≥50 nmol/L. In conclusion, weight and BMI were significantly correlated with bone parameters in both groups and age was significantly correlated with BMD at the femoral neck for women living in Brazil only. Although 25(OH)D concentrations were not correlated to bone parameters at any sites, in either country, PTH concentrations showed a significant correlation with total vBMD at the 66% site for women living in England. Secondary hyperparathyroidism was more common amongst those with deficient and insufficient vitamin D status.

Download Full-text

Leisure-time physical activity and circulating 25-hydroxyvitamin D levels in cancer survivors: a cross-sectional analysis using data from the US National Health and Nutrition Examination Survey

BMJ Open ◽

10.1136/bmjopen-2017-016064 ◽

2017 ◽

Vol 7 (7) ◽

pp. e016064 ◽

Cited By ~ 11

Author(s):

Lin Yang ◽

Adetunji T Toriola

Keyword(s):

Leisure Time ◽

Leisure Time Physical Activity ◽

Nutrition Examination Survey ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Health And Nutrition ◽

The Us ◽

25 Hydroxyvitamin D ◽

Using Data ◽

Sectional Analysis

Download Full-text

Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: results from the EPIC–Oxford study

Public Health Nutrition ◽

10.1017/s1368980010002454 ◽

2010 ◽

Vol 14 (2) ◽

pp. 340-346 ◽

Cited By ~ 103

Author(s):

Francesca L Crowe ◽

Marinka Steur ◽

Naomi E Allen ◽

Paul N Appleby ◽

Ruth C Travis ◽

...

Keyword(s):

Vitamin D ◽

Plasma Concentrations ◽

White Men ◽

Food Sources ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Animal Product ◽

25 Hydroxyvitamin D ◽

Vitamin D 3 ◽

Sectional Analysis

AbstractObjectiveVegetarians and vegans exclude certain food sources of vitamin D from their diet, but it is not clear to what extent this affects plasma concentrations of 25-hydroxyvitamin D (25(OH)D). The objective was to investigate differences in vitamin D intake and plasma concentrations of 25(OH)D among meat eaters, fish eaters, vegetarians and vegans.DesignA cross-sectional analysis.SettingUnited Kingdom.SubjectsPlasma 25(OH)D concentrations were measured in 2107 white men and women (1388 meat eaters, 210 fish eaters, 420 vegetarians and eighty-nine vegans) aged 20–76 years from the European Prospective Investigation into Cancer and Nutrition (EPIC)–Oxford cohort.ResultsPlasma 25(OH)D concentrations reflected the degree of animal product exclusion and, hence, dietary intake of vitamin D; meat eaters had the highest mean intake of vitamin D (3·1 (95 % CI 3·0, 3·2) μg/d) and mean plasma 25(OH)D concentrations (77·0 (95 % CI 75·4, 78·8) nmol/l) and vegans the lowest (0·7 (95 % CI 0·6, 0·8) μg/d and 55·8 (95 % CI 51·0, 61·0) nmol/l, respectively). The magnitude of difference in 25(OH)D concentrations between meat eaters and vegans was smaller (20 %) among those participants who had a blood sample collected during the summer months (July–September) compared with the winter months (38 %; January–March). The prevalence of low plasma concentrations of 25(OH)D (<25 nmol/l) during the winter and spring ranged from <1 % to 8 % across the diet groups.ConclusionsPlasma 25(OH)D concentrations were lower in vegetarians and vegans than in meat and fish eaters; diet is an important determinant of plasma 25(OH)D in this British population.

Download Full-text

Vitamin D deficiency is associated with anaemia among African Americans in a US cohort

British Journal Of Nutrition ◽

10.1017/s0007114515000999 ◽

2015 ◽

Vol 113 (11) ◽

pp. 1732-1740 ◽

Cited By ~ 20

Author(s):

Ellen M. Smith ◽

Jessica A. Alvarez ◽

Greg S. Martin ◽

Susu M. Zughaier ◽

Thomas R. Ziegler ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Bivariate Analysis ◽

Vitamin D Status ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

The Us ◽

Inflammatory Processes ◽

25 Hydroxyvitamin D ◽

Sectional Analysis

Vitamin D deficiency is highly prevalent in the US population and is associated with numerous diseases, including those characterised by inflammatory processes. We aimed to investigate the link between vitamin D status and anaemia, hypothesising that lower vitamin D status would be associated with increased odds of anaemia, particularly anaemia with inflammation. A secondary aim was to examine the effects of race in the association between vitamin D status and anaemia. We conducted a cross-sectional analysis in a cohort of generally healthy adults in Atlanta, GA (n 638). Logistic regression was used to evaluate the association between vitamin D status and anaemia. Serum 25-hydroxyvitamin D (25(OH)D) < 50 nmol/l (compared to 25(OH)D ≥ 50 nmol/l) was associated with anaemia in bivariate analysis (OR 2·64, 95 % CI 1·43, 4·86). There was significant effect modification by race (P= 0·003), such that blacks with 25(OH)D < 50 nmol/l had increased odds of anaemia (OR 6·42, 95 % CI 1·88, 21·99), v. blacks with 25(OH)D ≥ 50 nmol/l, controlling for potential confounders; this association was not apparent in whites. When categorised by subtype of anaemia, blacks with 25(OH)D < 50 nmol/l had significantly increased odds of anaemia with inflammation than blacks with serum 25(OH)D ≥ 50 nmol/l (OR 8·42, 95 % CI 1·96, 36·23); there was no association with anaemia without inflammation. In conclusion, serum 25(OH)D < 50 nmol/l was significantly associated with anaemia, particularly anaemia with inflammation, among blacks in a generally healthy adult US cohort.

Download Full-text

Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis

Public Health Nutrition ◽

10.1017/s1368980013000736 ◽

2013 ◽

Vol 16 (8) ◽

pp. 1414-1418 ◽

Cited By ~ 11

Author(s):

Laura E Tomedi ◽

Chung-Chou H Chang ◽

PK Newby ◽

Rhobert W Evans ◽

James F Luther ◽

...

Keyword(s):

Factor Analysis ◽

Pregnant Women ◽

Serum Retinol ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Micronutrient Status ◽

25 Hydroxyvitamin D ◽

Antidepressant Use ◽

Confounder Adjustment ◽

Sectional Analysis

AbstractObjectivePre-pregnancy obesity has been associated with adverse birth outcomes. Poor essential fatty acid (EFA) and micronutrient status during pregnancy may contribute to these associations. We assessed the associations between pre-pregnancy BMI and nutritional patterns of maternal micronutrient and EFA status during mid-pregnancy.DesignA cross-sectional analysis from a prospective cohort study. Women provided non-fasting blood samples at ≤20 weeks’ gestation that were assayed for red cell EFA; plasma folate, homocysteine and ascorbic acid; and serum retinol, 25-hydroxyvitamin D, α-tocopherol, soluble transferrin receptors and carotenoids. These nutritional biomarkers were employed in a factor analysis and three patterns were derived: EFA, Micronutrients and Carotenoids.SettingThe Antidepressant Use During Pregnancy Study, Pittsburgh, PA, USA.SubjectsPregnant women (n 129).ResultsAfter adjustment for parity, race/ethnicity and age, obese pregnant women were 3·0 (95 % CI 1·1, 7·7) times more likely to be in the lowest tertile of the EFA pattern and 4·5 (95 % CI 1·7, 12·3) times more likely to be in the lowest tertile of the Carotenoid pattern compared with their lean counterparts. We found no association between pre-pregnancy obesity and the Micronutrient pattern after confounder adjustment.ConclusionsOur results suggest that obese pregnant women have diminished EFA and carotenoid concentrations.

Download Full-text