scholarly journals Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Fa-liang Wang ◽  
Xiao-li Zhang ◽  
Ming Yang ◽  
Jun Lin ◽  
Yong-fang Yue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chinese Women ◽  
Southern China ◽  
Meta Analysis ◽  
Northern China ◽  
Cancer Tissue ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Breast Fibroadenoma ◽  
Cancer Tissues

Abstract Background Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalence of MMTV-LV in women breast cancer tissue varies in different countries and its dependent factors remain inconclusive. Methods In the first part of the study, a case-control study was performed. 119 breast cancer samples (84 from Northern China and 35 from Southern China) and 50 breast fibroadenoma specimens were collected from Chinese women patients. MMTV-like env sequence and the homology to MMTV env gene were analysed by semi-nested polymerase chain reaction (PCR). We also explored the association of MMTV-LV prevalence with sample sources (Southern and Northern China) and patients’ clinicopathological characteristics. To investigate the dependent factors of the prevalence of MMTV-LV in breast cancer worldwide, a meta-analysis was conducted in the second part of the study. Results We found that the prevalence of MMTV-LV was much higher in breast cancer tissues (17.65%) than that in breast fibroadenoma specimens (4.00%) (P < 0.05). MMTV-LV prevalence in Chinese women breast cancer tissues was significantly different between Southern China (5.71%) and Northern China (22.62%) (P < 0.05). The prevalence of MMTV-LV also associates significantly with expression of HER2, but shows no significant correlation with other parameters. In the meta-analysis, we found that MMTV-LV prevalence in breast cancer tissue was dependent on the distribution of M. domesticus mouse (M. d), M. musculus mouse (M.m) and M.castaneus mouse (M.c) worldwide (P < 0.05). Conclusion The distribution of house mice may be a crucial environmental factor that explains the geographic differences in human breast cancer incidence. Our findings may provide a potential avenue of prevention, diagnosis and treatment for breast cancer.

scholarly journals Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth

2015 ◽  
Vol 29 (10) ◽  
pp. 1468-1485 ◽  
Author(s):  
Cecilia J. Proietti ◽  
Franco Izzo ◽  
María Celeste Díaz Flaqué ◽  
Rosalía Cordo Russo ◽  
Leandro Venturutti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Cancer Growth ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Promoter

Abstract Accumulated findings have demonstrated the presence of bidirectional interactions between progesterone receptor (PR) and the ErbB family of receptor tyrosine kinases signaling pathways in breast cancer. We previously revealed signal transducer and activator of transcription 3 (Stat3) as a nodal convergence point between said signaling pathways proving that Stat3 is activated by one of the ErbBs' ligands, heregulin (HRG)β1 via ErbB2 and through the co-option of PR as a signaling molecule. Here, we found that HRGβ1 induced Stat3 recruitment to the promoters of the progestin-regulated cell cycle modulators Bcl-XL and p21CIP1 and also stimulated Stat3 binding to the mouse mammary tumor virus promoter, which carries consensus progesterone response elements. Interestingly, HRGβ1-activated Stat3 displayed differential functions on PR activity depending on the promoter bound. Indeed, Stat3 was required for PR binding in bcl-X, p21CIP1, and c-myc promoters while exerting a PR coactivator function on the mouse mammary tumor virus promoter. Stat3 also proved to be necessary for HRGβ1-induced in vivo tumor growth. Our results endow Stat3 a novel function as a coregulator of HRGβ1-activated PR to promote breast cancer growth. These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3, that contribute to determine the context-dependent transcriptional actions of PR.

scholarly journals Distribution of Cd and Cu Fractions in Chinese Soils and Their Relationships with Soil pH: A Meta-Analysis

2019 ◽  
Vol 11 (2) ◽  
pp. 337 ◽  
Author(s):  
Yinzhong Ning ◽  
Xinmu Zhang ◽  
Binzhe Li ◽  
Yajing Wang ◽  
Jingheng Guo
Keyword(s):  
Health Risks ◽  
Soil Ph ◽  
Southern China ◽  
Meta Analysis ◽  
Northern China ◽  
Residual Fraction ◽  
Potentially Toxic Metals ◽  
National Assessment ◽  
Exchangeable Fraction ◽  
Fraction Distribution

Soil contamination by potentially toxic metals (PTMs) has become a public concern in China. However, the distribution and controlling factors of soil PTM fractions remain largely unknown, limiting our ability to assess their health risks and thus to make sound controlling polices. Here, we investigate the fraction distribution of cadmium (Cd) and copper (Cu) in Chinese soils and their relationships with soil pH, based on a national meta-analysis of 163 published literatures. Exchangeable Cd in southern China accounted for 19.50 ± 14.97% of total Cd, significantly (p < 0.01) higher than the corresponding 13.42 ± 6.95% in northern China. Potentially available fractions constituted about 60% of total Cd at the national scale. By contrast, about half of soil Cu existed in unavailable residual fraction. Phytoavailable (i.e., exchangeable) fraction accounted for only 2.71 ± 1.65% and 2.54 ± 1.58% of total Cu in northern and southern China, respectively. Percentages of exchangeable Cd and Cu were negatively correlated (p < 0.01) with soil pH, while potentially available fractions increased significantly (p < 0.05) with soil pH. Our results provide the first national assessment of Cd and Cu fraction distribution and their responses to soil pH variations, highlighting the necessity to consider their fraction distribution and soil properties when assessing the health risks of soil PTM contamination in China.

A Mouse Mammary Tumor Virus-Like Long Terminal Repeat Superantigen in Human Breast Cancer

2004 ◽  
Vol 64 (12) ◽  
pp. 4105-4111 ◽  
Author(s):  
Yue Wang ◽  
Jian-Dong Jiang ◽  
Dongping Xu ◽  
Yan Li ◽  
Chunfeng Qu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Long Terminal Repeat ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Human Breast Cancer ◽  
Terminal Repeat ◽  
Human Breast ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Abigail Morales-Sánchez ◽  
Tzindilú Molina-Muñoz ◽  
Juan L. E. Martínez-López ◽  
Paulina Hernández-Sancén ◽  
Alejandra Mantilla ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Epstein Barr Virus ◽  
Mexican Women ◽  
Mammary Tumor Virus ◽  
Barr Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Epstein Barr

Increased incidence of mouse mammary tumor virus-related antigen in tunisian patients with breast cancer

1984 ◽  
Vol 33 (3) ◽  
pp. 305-308 ◽  
Author(s):  
P. H. Levine ◽  
R. Mesa-Tejada ◽  
I. Keydar ◽  
F. Tabbane ◽  
S. Spiefelman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tunisian Patients ◽  
Tumor Virus
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